2QC6
| Protein kinase CK2 in complex with DBC | 分子名称: | 3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE, Casein kinase II subunit alpha | 著者 | Battistutta, R. | 登録日 | 2007-06-19 | 公開日 | 2008-02-26 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationships. J.Med.Chem., 51, 2008
|
|
4DGL
| |
4DGM
| Crystal Structure of maize CK2 in complex with the inhibitor apigenin | 分子名称: | 1,2-ETHANEDIOL, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, Casein kinase II subunit alpha, ... | 著者 | Lolli, G, Mazzorana, M, Battistutta, R. | 登録日 | 2012-01-26 | 公開日 | 2012-08-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. Biochemistry, 51, 2012
|
|
4DGN
| Crystal Structure of maize CK2 in complex with the inhibitor luteolin | 分子名称: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, Casein kinase II subunit alpha | 著者 | Lolli, G, Mazzorana, M, Battistutta, R. | 登録日 | 2012-01-26 | 公開日 | 2012-08-01 | 最終更新日 | 2013-01-02 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. Biochemistry, 51, 2012
|
|
3PE1
| Crystal structure of human protein kinase CK2 alpha subunit in complex with the inhibitor CX-4945 | 分子名称: | 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, Casein kinase II subunit alpha, SULFATE ION | 著者 | Battistutta, R, Papinutto, E, Lolli, G, Pierre, F, Haddach, M, Ryckman, D.M. | 登録日 | 2010-10-25 | 公開日 | 2011-09-07 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer. Biochemistry, 50, 2011
|
|
3PE2
| Crystal structure of human protein kinase CK2 in complex with the inhibitor CX-5011 | 分子名称: | 5-[(3-ethynylphenyl)amino]pyrimido[4,5-c]quinoline-8-carboxylic acid, Casein kinase II subunit alpha, SULFATE ION | 著者 | Battistutta, R, Papinutto, E, Lolli, G, Pierre, F, Haddach, M, Ryckman, D.M. | 登録日 | 2010-10-25 | 公開日 | 2011-09-07 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer. Biochemistry, 50, 2011
|
|
3R0T
| Crystal structure of human protein kinase CK2 alpha subunit in complex with the inhibitor CX-5279 | 分子名称: | 1,2-ETHANEDIOL, 3-(cyclopropylamino)-5-{[3-(trifluoromethyl)phenyl]amino}pyrimido[4,5-c]quinoline-8-carboxylic acid, Casein kinase II subunit alpha, ... | 著者 | Battistutta, R, Papinutto, E, Lolli, G, Pierre, F, Haddach, M, Ryckman, D.M. | 登録日 | 2011-03-09 | 公開日 | 2011-12-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer. Biochemistry, 50, 2011
|
|
1NA7
| |
1OM1
| Crystal structure of maize CK2 alpha in complex with IQA | 分子名称: | (5-OXO-5,6-DIHYDRO-INDOLO[1,2-A]QUINAZOLIN-7-YL)-ACETIC ACID, Casein kinase II, alpha chain | 著者 | Battistutta, R, De Moliner, E, Zanotti, G. | 登録日 | 2003-02-24 | 公開日 | 2004-02-24 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA). Biochem.J., 374, 2003
|
|
6ISJ
| |
3PVG
| Crystal structure of Z. mays CK2 alpha subunit in complex with the inhibitor 4,5,6,7-tetrabromo-1-carboxymethylbenzimidazole (K68) | 分子名称: | (4,5,6,7-tetrabromo-1H-benzimidazol-1-yl)acetic acid, Casein kinase II subunit alpha | 著者 | Papinutto, E, Franchin, C, Battistutta, R. | 登録日 | 2010-12-07 | 公開日 | 2010-12-15 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | ATP site-directed inhibitors of protein kinase CK2: an update. Curr Top Med Chem, 11, 2011
|
|
3Q04
| |
3PWD
| Crystal structure of maize CK2 in complex with NBC (Z1) | 分子名称: | 8-hydroxy-4-methyl-9-nitro-2H-benzo[g]chromen-2-one, Casein kinase II subunit alpha | 著者 | Battistutta, R, Mazzorana, M. | 登録日 | 2010-12-08 | 公開日 | 2011-11-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A Cell.Mol.Life Sci., 69, 2012
|
|
3PZH
| |
3QA0
| |
3Q9Z
| Crystal structure of human CK2 alpha in complex with Quinalizarin at pH 6.5 | 分子名称: | 1,2,5,8-tetrahydroxyanthracene-9,10-dione, 1,2-ETHANEDIOL, Casein kinase II subunit alpha, ... | 著者 | Battistutta, R, Ranchio, A, Papinutto, E. | 登録日 | 2011-01-10 | 公開日 | 2012-01-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural and functional analysis of the flexible regions of the catalytic alpha-subunit of protein kinase CK2 To be Published
|
|
3Q9X
| Crystal structure of human CK2 alpha in complex with emodin at pH 6.5 | 分子名称: | 1,2-ETHANEDIOL, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, ... | 著者 | Battistutta, R, Ranchio, A, Papinutto, E. | 登録日 | 2011-01-10 | 公開日 | 2012-01-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural and functional analysis of the flexible regions of the catalytic alpha-subunit of protein kinase CK2 To be Published
|
|
3Q9Y
| Crystal structure of human CK2 alpha in complex with Quinalizarin at pH 8.5 | 分子名称: | 1,2,5,8-tetrahydroxyanthracene-9,10-dione, Casein kinase II subunit alpha, SULFATE ION | 著者 | Battistutta, R, Ranchio, A, Papinutto, E. | 登録日 | 2011-01-10 | 公開日 | 2012-01-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and functional analysis of the flexible regions of the catalytic alpha-subunit of protein kinase CK2 To be Published
|
|
3Q9W
| |
3FWQ
| Inactive conformation of human protein kinase CK2 catalytic subunit | 分子名称: | CHLORIDE ION, Casein kinase II subunit alpha, GLYCEROL, ... | 著者 | Niefind, K, Raaf, J, Issinger, O.G. | 登録日 | 2009-01-19 | 公開日 | 2009-02-17 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | First inactive conformation of CK2 alpha, the catalytic subunit of protein kinase CK2 J.Mol.Biol., 386, 2009
|
|
3OFM
| Structure of a human CK2alpha prime, the paralog isoform of the catalytic subunit of protein kinase CK2 from Homo sapiens | 分子名称: | 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol, CHLORIDE ION, Casein kinase II subunit alpha' | 著者 | Bischoff, N, Olsen, B, Raaf, J, Bretner, M, Issinger, O.-G, Niefind, K. | 登録日 | 2010-08-15 | 公開日 | 2011-01-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis of the reduced affinity between the protein kinase CK2 subunits CK2alpha prime and CK2beta J.Mol.Biol., 407, 2011
|
|