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Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1647
Descriptor:	5-amino-3-[7-(cyclobutyloxy)quinolin-3-yl]-1-cyclohexyl-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2014-09-17
Release date:	2014-10-15
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1647 to be published

4WG3

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1610
Descriptor:	3-(7-ethoxynaphthalen-2-yl)-1-(2-methylpropyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2014-09-17
Release date:	2014-10-15
Last modified:	2025-03-12
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1610 to be published

4WG4

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1613
Descriptor:	3-(7-ethoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A.
Deposit date:	2014-09-17
Release date:	2014-10-15
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1613 to be published

4Y5Q

Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with AMP
Descriptor:	ADENOSINE MONOPHOSPHATE, CALCIUM ION, Calmodulin-domain protein kinase 1, ...
Authors:	Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2015-02-11
Release date:	2015-02-25
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with AMP To Be Published

9EIE

Trypanosomatid-specific protein of unknown function
Descriptor:	GLYCEROL, POTASSIUM ION, Trypanosomatid-specific protein of unknown function
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2024-11-25
Release date:	2025-02-26
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Prediction and determination of a Structure Genomics target after 20 years To Be Published

4DS2

Ubiquitin conjugating enzyme (putative) from Trypanosoma cruzi
Descriptor:	Ubiquitin-conjugating enzyme E2, putative
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2012-02-17
Release date:	2012-02-29
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.63 Å)
Cite:	Ubiquitin conjugating enzyme (putative) from Trypanosoma cruzi To be Published

3CHB

CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE
Descriptor:	2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHOLERA TOXIN, UNKNOWN ATOM OR ION, ...
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1998-03-24
Release date:	1998-08-12
Last modified:	2024-11-20
Method:	X-RAY DIFFRACTION (1.25 Å)
Cite:	The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site. J.Mol.Biol., 282, 1998

2CHB

CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE
Descriptor:	CHOLERA TOXIN, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1997-06-03
Release date:	1997-12-03
Last modified:	2024-11-20
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural studies of receptor binding by cholera toxin mutants. Protein Sci., 6, 1997

6VMT

Leishmania major Programmed Cell Death Protein 5 Homolog
Descriptor:	Programmed Cell Death Protein 5 Homolog
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2020-01-28
Release date:	2020-02-26
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.501 Å)
Cite:	Leishmania major Programmed Cell Death Protein 5 Homolog To be published

6VYE

6-phosphogluconolactonase from Trypanosoma cruzi
Descriptor:	6-phosphogluconolactonase, GLYCEROL, PHOSPHATE ION
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2020-02-26
Release date:	2020-03-18
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	6-phosphogluconolactonase from Trypanosoma cruzi To be published

2QT8

Coproporphyrinogen III oxidase from Leishmania major
Descriptor:	ACETATE ION, Coproporphyrinogen III oxidase
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-08-01
Release date:	2007-09-04
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Coproporphyrinogen III oxidase from Leishmania major. To be Published

2Q0X

Alpha/Beta hydrolase fold protein of unknown function
Descriptor:	GLYCEROL, Uncharacterized protein
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-05-22
Release date:	2007-06-26
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Structure of a Trypanosoma brucei alpha/beta-hydrolase fold protein with unknown function. Acta Crystallogr.,Sect.F, 64, 2008

1HTL

MUTATION OF A BURIED RESIDUE CAUSES LACK OF ACTIVITY BUT NO CONFORMATIONAL CHANGE: CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN MUTANT VAL 97--> LYS
Descriptor:	HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1995-02-15
Release date:	1995-04-20
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli. Nat.Struct.Biol., 2, 1995

1LLR

CHOLERA TOXIN B-PENTAMER WITH LIGAND BMSC-0012
Descriptor:	3-AMINO-4-{3-[2-(2-PROPOXY-ETHOXY)-ETHOXY]-PROPYLAMINO}-CYCLOBUT-3-ENE-1,2-DIONE, 5-aminocarbonyl-3-nitrophenyl alpha-D-galactopyranoside, CHOLERA TOXIN B SUBUNIT
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	2002-04-30
Release date:	2002-08-14
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (1.46 Å)
Cite:	Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin. J.Am.Chem.Soc., 124, 2002

3BNW

Crystal structure of riboflavin kinase from Trypanosoma brucei
Descriptor:	Riboflavin kinase, putative
Authors:	Merritt, E.A, Holmes, M, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-12-14
Release date:	2008-01-08
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Riboflavin kinase from Trypanosoma brucei. To be Published

3LC0

Histidyl-tRNA synthetase from Trypanosoma cruzi (Histidine complex)
Descriptor:	HISTIDINE, Histidyl-tRNA synthetase
Authors:	Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-01-08
Release date:	2010-01-19
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Crystal Structures of Trypanosomal Histidyl-tRNA Synthetase Illuminate Differences between Eukaryotic and Prokaryotic Homologs. J.Mol.Biol., 397, 2010

3M3I

Hypothetical protein from Leishmania major
Descriptor:	Putative uncharacterized protein
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2010-03-09
Release date:	2010-03-23
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Hypothetical protein from Leishmania major To be Published

1LT5

HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH THIODIGALACTOSIDE
Descriptor:	HEAT-LABILE ENTEROTOXIN, beta-D-galactopyranose-(1-1)-1-thio-beta-D-galactopyranose
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1997-09-30
Release date:	1997-12-03
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structural foundation for the design of receptor antagonists targeting Escherichia coli heat-labile enterotoxin. Structure, 5, 1997

1LT6

HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH METANITROPHENYLGALACTOSIDE
Descriptor:	3-nitrophenyl alpha-D-galactopyranoside, HEAT-LABILE ENTEROTOXIN
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1997-10-01
Release date:	1997-12-03
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Structural foundation for the design of receptor antagonists targeting Escherichia coli heat-labile enterotoxin. Structure, 5, 1997

1CHQ

SURPRISING LEADS FOR A CHOLERA TOXIN RECEPTOR BINDING ANTAGONIST; CRYSTALLOGRAPHIC STUDIES OF CTB MUTANTS
Descriptor:	CHOLERA TOXIN B PENTAMER
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1995-02-15
Release date:	1996-03-08
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants. Structure, 3, 1995

1CHP

SURPRISING LEADS FOR A CHOLERA TOXIN RECEPTOR BINDING ANTAGONIST; CRYSTALLOGRAPHIC STUDIES OF CTB MUTANTS
Descriptor:	CHLORIDE ION, CHOLERA TOXIN B PENTAMER
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1995-02-15
Release date:	1996-03-08
Last modified:	2024-11-20
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants. Structure, 3, 1995

1LUQ

Full Matrix Error Analysis of Streptavidin
Descriptor:	(4S)-2-METHYL-2,4-PENTANEDIOL, BIOTIN, GLYCEROL, ...
Authors:	Merritt, E.A, Le Trong, I.
Deposit date:	2002-05-23
Release date:	2003-09-09
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (0.96 Å)
Cite:	Full Matrix Error Analysis of Streptavidin To be Published

1QCB

ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER
Descriptor:	PROTEIN (HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER)
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1999-04-30
Release date:	2003-06-10
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Crystal Structures of the B-Pentamer from E. coli Enterotoxin LT-IIb To be Published

1QB5

ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER
Descriptor:	PROTEIN (HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER)
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1999-04-30
Release date:	2003-06-10
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Crystal Structures of the B-Pentamer from E. coli Enterotoxin LT-IIb To be Published

3S4O

Protein Tyrosine Phosphatase (putative) from Leishmania major
Descriptor:	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Protein tyrosine phosphatase-like protein, THIOSULFATE
Authors:	Merritt, E.A, Arakaki, T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP), Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2011-05-19
Release date:	2011-06-15
Last modified:	2024-10-09
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Protein Tyrosine Phosphatase from Leishmania major To be Published

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