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HIV-1 Nef protein in complex with single domain antibody sdAb19 and an engineered Hck SH3 domain
Descriptor:	Protein Nef, Tyrosine-protein kinase HCK, single domain antibody sdAb19
Authors:	Geyer, M, Lulf, S.
Deposit date:	2014-02-12
Release date:	2014-03-26
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody. Retrovirology, 11, 2014

HIV-1 NEF protein in complex with engineered HCK SH3 domain
Descriptor:	1,2-ETHANEDIOL, Protein Nef, Tyrosine-protein kinase HCK
Authors:	Horenkamp, F.A, Schulte, A, Weyand, M, Geyer, M.
Deposit date:	2011-03-29
Release date:	2011-04-27
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Conformation of the Dileucine-Based Sorting Motif in HIV-1 Nef Revealed by Intermolecular Domain Assembly. Traffic, 12, 2011

Crystal structure of SIVmac239 Nef in an ExxxLM endocytic sorting motif bound state
Descriptor:	Protein Nef, SER-GLN-ILE-LYS-ARG-LEU-LEU-SER
Authors:	Manrique, S, Horenkamp, F.A, Anand, K, Geyer, M.
Deposit date:	2017-04-30
Release date:	2017-08-16
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3. Nat Commun, 8, 2017

Crystal structure of SIVmac239 Nef bound to an engineered Hck SH3 domain
Descriptor:	Protein Nef, Tyrosine-protein kinase HCK,Tyrosine-protein kinase HCK
Authors:	Horenkamp, F.A, Anand, K, Geyer, M.
Deposit date:	2017-04-30
Release date:	2017-08-16
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.78 Å)
Cite:	Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3. Nat Commun, 8, 2017