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5DBO
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BU of 5dbo by Molmil
Crystal structure of the tetrameric eIF2B-beta2-delta2 complex from C. thermophilum
分子名称: Translation initiation factor eIF2b-like protein,Translation initiation factor eIF2b-like protein, Translation initiation factor eif-2b-like protein
著者Kuhle, B, Ficner, R.
登録日2015-08-21
公開日2015-10-07
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.
Nucleic Acids Res., 43, 2015
4ZEM
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BU of 4zem by Molmil
Crystal structure of eIF2B beta from Chaetomium thermophilum
分子名称: Translation initiation factor eIF2b-like protein,Translation initiation factor eIF2b-like protein
著者Kuhle, B, Ficner, R.
登録日2015-04-20
公開日2015-09-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.
Nucleic Acids Res., 43, 2015
4ZEO
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BU of 4zeo by Molmil
Crystal structure of eIF2B delta from Chaetomium thermophilum
分子名称: Translation initiation factor eif-2b-like protein
著者Kuhle, B, Ficner, R.
登録日2015-04-20
公開日2015-09-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.
Nucleic Acids Res., 43, 2015
6NLY
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BU of 6nly by Molmil
Fragment of human mitochondrial Alanyl-tRNA Synthetase C-Ala domain
分子名称: Alanine--tRNA ligase, mitochondrial
著者Kuhle, B, Schimmel, P.
登録日2019-01-09
公開日2020-01-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.307 Å)
主引用文献Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs.
Nat Commun, 11, 2020
6NLQ
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BU of 6nlq by Molmil
Human Mitochondrial Alanyl-tRNA Synthetase C-terminal domain
分子名称: Alanine--tRNA ligase, mitochondrial, CALCIUM ION
著者Kuhle, B, Schimmel, P.
登録日2019-01-08
公開日2020-01-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs.
Nat Commun, 11, 2020
6NOW
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BU of 6now by Molmil
Human Mitochondrial Alanyl-tRNA Synthetase C-Ala domain
分子名称: Alanine--tRNA ligase, mitochondrial
著者Kuhle, B, Schimmel, P.
登録日2019-01-16
公開日2020-01-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (4.099 Å)
主引用文献Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs.
Nat Commun, 11, 2020
7TZB
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BU of 7tzb by Molmil
Crystal structure of the human mitochondrial seryl-tRNA synthetase (mt SerRS) bound with a seryl-adenylate analogue
分子名称: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Serine--tRNA ligase, mitochondrial
著者Kuhle, B, Hirschi, M, Doerfel, L, Lander, G, Schimmel, P.
登録日2022-02-15
公開日2022-09-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
Nat Commun, 13, 2022
4TMZ
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BU of 4tmz by Molmil
Translation initiation factor eIF5B (517-858) from C. thermophilum, bound to GTPgammaS and potassium
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, CHLORIDE ION, GLYCEROL, ...
著者Kuhle, B, Ficner, R.
登録日2014-06-02
公開日2014-09-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
Embo J., 33, 2014
4TN1
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BU of 4tn1 by Molmil
Translation initiation factor eIF5B (517-858) mutant D533R from C. thermophilum, bound to GTPgammaS
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, eIF5B
著者Kuhle, B, Ficner, R.
登録日2014-06-02
公開日2014-09-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
Embo J., 33, 2014
4TMV
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BU of 4tmv by Molmil
Translation initiation factor eIF5B (517-858) from C. thermophilum, bound to GTPgammaS and Sodium
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
著者Kuhle, B, Ficner, R.
登録日2014-06-02
公開日2014-09-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
Embo J., 33, 2014
4TMW
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BU of 4tmw by Molmil
Translation initiation factor eIF5B (517-858) from C. thermophilum, bound to GTP and Sodium
分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SODIUM ION, ...
著者Kuhle, B, Ficner, R.
登録日2014-06-02
公開日2014-09-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
Embo J., 33, 2014
4TMT
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BU of 4tmt by Molmil
Translation initiation factor eIF5B (517-858) mutant D533A from C. thermophilum, bound to GTPgammaS
分子名称: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ...
著者Kuhle, B, Ficner, R.
登録日2014-06-02
公開日2014-09-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
Embo J., 33, 2014
4TMX
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BU of 4tmx by Molmil
Translation initiation factor eIF5B (517-858) mutant D533N from C. thermophilum, bound to GTP and sodium
分子名称: 1,2-ETHANEDIOL, ACETIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Kuhle, B, Ficner, R.
登録日2014-06-02
公開日2014-09-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
Embo J., 33, 2014
4N3S
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BU of 4n3s by Molmil
Crystal structure of eukaryotic translation initiation factor eIF5B (399-852) from Saccharomyces cerevisiae, apo form
分子名称: 1,2-ETHANEDIOL, Eukaryotic translation initiation factor 5B, GLYCEROL
著者Kuhle, B, Ficner, R.
登録日2013-10-07
公開日2014-07-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.832 Å)
主引用文献eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
Embo J., 33, 2014
4N3G
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BU of 4n3g by Molmil
Crystal structure of eukaryotic translation initiation factor eIF5B (870-1116) from Chaetomium thermophilum, domains III and IV
分子名称: CHLORIDE ION, Eukaryotic translation initiation factor 5B-like protein, eIF5B(870-C), ...
著者Kuhle, B, Ficner, R.
登録日2013-10-07
公開日2014-07-09
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.203 Å)
主引用文献eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
Embo J., 33, 2014
4N3N
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BU of 4n3n by Molmil
Crystal structure of eukaryotic translation initiation factor eIF5B (517-1116) from Chaetomium thermophilum, apo form
分子名称: Eukaryotic translation initiation factor 5B-like protein, eIF5B(517-C), LACTIC ACID
著者Kuhle, B, Ficner, R.
登録日2013-10-07
公開日2014-07-09
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.752 Å)
主引用文献eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
Embo J., 33, 2014
4NCN
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BU of 4ncn by Molmil
Crystal structure of eukaryotic translation initiation factor eIF5B (517-858) from Chaetomium thermophilum in complex with GTP
分子名称: ACETIC ACID, Eukaryotic translation initiation factor 5B-like protein, GLYCEROL, ...
著者Kuhle, B, Ficner, R.
登録日2013-10-24
公開日2014-07-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
Embo J., 33, 2014
4NCL
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BU of 4ncl by Molmil
Crystal structure of eukaryotic translation initiation factor eIF5B (517-970) from Chaetomium thermophilum in complex with GDP
分子名称: Eukaryotic translation initiation factor 5B-like protein, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Kuhle, B, Ficner, R.
登録日2013-10-24
公開日2014-07-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.115 Å)
主引用文献eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
Embo J., 33, 2014
4NCF
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BU of 4ncf by Molmil
Crystal structure of eukaryotic translation initiation factor eIF5B (399-852) from Saccharomyces cerevisiae in complex with GDP
分子名称: Eukaryotic translation initiation factor 5B, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Kuhle, B, Ficner, R.
登録日2013-10-24
公開日2014-07-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.015 Å)
主引用文献eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
Embo J., 33, 2014
8FFY
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BU of 8ffy by Molmil
Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA(UGA-TL)
分子名称: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Serine--tRNA ligase, mitochondrial, ...
著者Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G.
登録日2022-12-11
公開日2023-08-23
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural basis for a degenerate tRNA identity code and the evolution of bimodal specificity in human mitochondrial tRNA recognition.
Nat Commun, 14, 2023
6O76
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BU of 6o76 by Molmil
Human cytosolic Histidyl-tRNA synthetase (HisRS) with WHEP domain
分子名称: CHLORIDE ION, Histidine--tRNA ligase, cytoplasmic
著者Kuhle, B, Yang, X.L.
登録日2019-03-07
公開日2019-09-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.787 Å)
主引用文献CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells.
Proc.Natl.Acad.Sci.USA, 116, 2019
7U2A
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BU of 7u2a by Molmil
Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA (GCU)
分子名称: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, RNA (38-MER), Serine--tRNA ligase, ...
著者Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G.
登録日2022-02-23
公開日2022-09-14
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
Nat Commun, 13, 2022
7U2B
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BU of 7u2b by Molmil
Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA(GCU-TL)
分子名称: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, RNA (53-MER), Serine--tRNA ligase, ...
著者Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G.
登録日2022-02-23
公開日2022-09-14
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
Nat Commun, 13, 2022
8P8X
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BU of 8p8x by Molmil
Crystal structure of a pathogenic mutant variant of human mitochodnrial PheRS
分子名称: PHENYLALANINE, Phenylalanine--tRNA ligase, mitochondrial
著者Chen, W, Kuhle, B.
登録日2023-06-03
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Clinical and molecular characterization of novel FARS2 variants causing neonatal mitochondrial disease.
Mol.Genet.Metab., 140, 2023
4NOX
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BU of 4nox by Molmil
Structure of the nine-bladed beta-propeller of eIF3b
分子名称: CHLORIDE ION, Eukaryotic translation initiation factor 3 subunit B
著者Liu, Y, Neumann, P, Kuhle, B, Monecke, T, Ficner, R.
登録日2013-11-20
公開日2014-09-17
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.722 Å)
主引用文献Translation initiation factor eIF3b contains a nine-bladed beta-propeller and interacts with the 40S ribosomal subunit
Structure, 22, 2014

 

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