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4A50
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BU of 4a50 by Molmil
Crystal structure of human kinesin Eg5 in complex with 2-Amino-5-(3-methylphenyl)-5,5-diphenylpentanoic acid
分子名称: (2R)-2-AMINO-5-(3-METHYLPHENYL)-5,5-DIPHENYLPROPANOIC ACID, (2S)-2-AMINO-5-(3-METHYLPHENYL)-5,5-DIPHENYLPROPANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, ...
著者Kaan, H.Y.K, Kozielski, F.
登録日2011-10-24
公開日2012-10-31
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity.
J.Med.Chem., 55, 2012
4BBG
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BU of 4bbg by Molmil
Crystal structure of human kinesin Eg5 in complex with 3-(((2-Aminoethyl)sulfanyl)(3-ethylphenyl) phenylmethyl)phenol
分子名称: 3-[(R)-2-azanylethylsulfanyl-(3-ethylphenyl)-phenyl-methyl]phenol, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
著者Kaan, H.Y.K, Kozielski, F.
登録日2012-09-22
公開日2013-05-15
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Optimized S-Trityl-L-Cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models.
J.Med.Chem., 56, 2013
4AP0
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BU of 4ap0 by Molmil
The mitotic kinesin Eg5 in complex with Mg-ADP and ispinesib
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ISPINESIB MESILATE, ...
著者Schuettelkopf, A.W, Talapatra, S.K, Kozielski, F.
登録日2012-03-30
公開日2012-09-26
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.594 Å)
主引用文献The Structure of the Ternary Eg5-Adp-Ispinesib Complex
Acta Crystallogr.,Sect.D, 68, 2012
4A28
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BU of 4a28 by Molmil
Eg5-2
分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION
著者Talapatra, S.K, Kozielski, F.
登録日2011-09-22
公開日2012-10-31
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
4A14
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BU of 4a14 by Molmil
HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING
分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF7, MAGNESIUM ION
著者Klejnot, M, Kozielski, F.
登録日2011-09-14
公開日2012-01-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling.
Acta Crystallogr.,Sect.D, 68, 2012
4A5Y
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BU of 4a5y by Molmil
Intermediate state of human kinesin Eg5 in complex with Ispinesib
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ISPINESIB MESILATE, ...
著者Kaan, H.Y.K, Kozielski, F.
登録日2011-10-29
公開日2012-11-07
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献"Snapshots" of Ispinesib-Induced Conformational Changes in the Mitotic Kinesin Eg5.
J.Biol.Chem., 288, 2013
4B7B
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BU of 4b7b by Molmil
Eg5-3
分子名称: ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, CALCIUM ION, ...
著者Talapatra, S.K, Kozielski, F.
登録日2012-08-17
公開日2013-07-31
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
4AS7
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BU of 4as7 by Molmil
Eg5 complex 1
分子名称: ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, CHLORIDE ION, ...
著者Talapatra, S.K, Kozielski, F.
登録日2012-04-29
公開日2013-05-15
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
4BEX
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BU of 4bex by Molmil
Structure of human Cofilin1
分子名称: COFILIN-1
著者Klejnot, M, Gabrielsen, M, Cameron, J, Mleczak, A, Talapatra, S.K, Kozielski, F, Pannifer, A, Olson, M.F.
登録日2013-03-12
公開日2013-08-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Analysis of the Human Cofilin1 Structure Reveals Conformational Changes Required for Actin-Binding
Acta Crystallogr.,Sect.D, 69, 2013
4BN2
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BU of 4bn2 by Molmil
The crystal structure of kinesin-like protein KIF15
分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF15, MAGNESIUM ION
著者Klejnot, M, Falnikar, A, Ulaganathan, V, Cross, R, Baas, P, Kozielski, F.
登録日2013-05-13
公開日2014-01-15
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.695 Å)
主引用文献The Crystal Structure and Biochemical Characterization of Kif15: A Bifunctional Molecular Motor Involved in Bipolar Spindle Formation and Neuronal Development
Acta Crystallogr.,Sect.D, 70, 2014
4BXN
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BU of 4bxn by Molmil
Eg5(WT) complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, CHLORIDE ION, ...
著者Talapatra, S.K, Anthony, N.G, Mackay, S.P, Kozielski, F.
登録日2013-07-15
公開日2013-07-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.793 Å)
主引用文献The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
1CZ7
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BU of 1cz7 by Molmil
THE CRYSTAL STRUCTURE OF A MINUS-END DIRECTED MICROTUBULE MOTOR PROTEIN NCD REVEALS VARIABLE DIMER CONFORMATIONS
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MICROTUBULE MOTOR PROTEIN NCD
著者Kozielski, F.K, De Bonis, S, Burmeister, W, Cohen-Addad, C, Wade, R.
登録日1999-09-01
公開日1999-11-05
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The crystal structure of the minus-end-directed microtubule motor protein ncd reveals variable dimer conformations.
Structure Fold.Des., 7, 1999
7QUQ
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BU of 7quq by Molmil
BtubA(R284G,K286D,F287G):BtubB bacterial tubulin M-loop mutant forming a single protofilament (Prosthecobacter dejongeii)
分子名称: PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Tubulin beta, Tubulin domain-containing protein
著者Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J.
登録日2022-01-18
公開日2022-09-21
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics.
Sci Adv, 9, 2023
7QUP
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BU of 7qup by Molmil
D. melanogaster 13-protofilament microtubule
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J.
登録日2022-01-18
公開日2022-11-02
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics.
Sci Adv, 9, 2023
7QUC
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BU of 7quc by Molmil
D. melanogaster alpha/beta tubulin heterodimer in the GDP form
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J.
登録日2022-01-17
公開日2022-09-21
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics.
Sci Adv, 9, 2023
7QUD
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BU of 7qud by Molmil
D. melanogaster alpha/beta tubulin heterodimer in the GTP form
分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Tubulin alpha-1 chain, ...
著者Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J.
登録日2022-01-17
公開日2022-09-21
最終更新日2023-10-04
実験手法ELECTRON MICROSCOPY (3.47 Å)
主引用文献Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics.
Sci Adv, 9, 2023
3PYM
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BU of 3pym by Molmil
Structure of GAPDH 3 from S.cerevisiae at 2.0 A resolution
分子名称: Glyceraldehyde-3-phosphate dehydrogenase 3, MESO-ERYTHRITOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Garcia-Saez, I, Kozielski, F, Job, D, Boscheron, C.
登録日2010-12-13
公開日2012-01-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献

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