8DBD
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8DBE
| Human PRPS1 with ADP; Hexamer | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Hvorecny, K.L, Kollman, J.M. | Deposit date: | 2022-06-14 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
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8DBL
| Human PRPS1 with Phosphate and PRPP; Hexamer | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Hvorecny, K.L, Kollman, J.M. | Deposit date: | 2022-06-14 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
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8DBJ
| Human PRPS1 with Phosphate, ATP, and R5P; Filament Interface | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Hvorecny, K.L, Kollman, J.M. | Deposit date: | 2022-06-14 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2 Å) | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
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8DBN
| Human PRPS1-E307A engineered mutation with Phosphate, ATP, and R5P; Hexamer | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Hvorecny, K.L, Kollman, J.M. | Deposit date: | 2022-06-14 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
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8DBC
| Human PRPS1 with Phosphate; Hexamer | Descriptor: | PHOSPHATE ION, Ribose-phosphate pyrophosphokinase 1 | Authors: | Hvorecny, K.L, Kollman, J.M. | Deposit date: | 2022-06-14 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
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8DBM
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8DBK
| Human PRPS1 with Phosphate, ATP, and R5P; Hexamer with resolved catalytic loops | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ... | Authors: | Hvorecny, K.L, Kollman, J.M. | Deposit date: | 2022-06-14 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
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8DBI
| Human PRPS1 with Phosphate, ATP, and R5P; Hexamer | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Hvorecny, K.L, Kollman, J.M. | Deposit date: | 2022-06-14 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2 Å) | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
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7MIH
| Human CTPS2 bound to inhibitor R80 | Descriptor: | CTP synthase 2, GLUTAMINE, MAGNESIUM ION, ... | Authors: | Lynch, E.M, Dimattia, M.A, Kollman, J.M. | Deposit date: | 2021-04-16 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MIG
| Human CTPS1 bound to inhibitor T35 | Descriptor: | 2-{2-[(cyclopropanesulfonyl)amino]-1,3-thiazol-4-yl}-2-methyl-N-{5-[6-(trifluoromethyl)pyrazin-2-yl]pyridin-2-yl}propanamide, CTP synthase 1, GLUTAMINE, ... | Authors: | Lynch, E.M, Dimattia, M.A, Kollman, J.M. | Deposit date: | 2021-04-16 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MH0
| Human CTPS1 bound to CTP | Descriptor: | CTP synthase 1, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION | Authors: | Lynch, E.M, Kollman, J.M. | Deposit date: | 2021-04-14 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (6.2 Å) | Cite: | Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MIV
| Mouse CTPS2-I250T bound to inhibitor R80 | Descriptor: | CTP synthase 2, GLUTAMINE, MAGNESIUM ION, ... | Authors: | Lynch, E.M, Dimattia, M.A, Kollman, J.M. | Deposit date: | 2021-04-17 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MII
| Human CTPS2 bound to inhibitor T35 | Descriptor: | 2-{2-[(cyclopropanesulfonyl)amino]-1,3-thiazol-4-yl}-2-methyl-N-{5-[6-(trifluoromethyl)pyrazin-2-yl]pyridin-2-yl}propanamide, CTP synthase 2, GLUTAMINE, ... | Authors: | Lynch, E.M, Dimattia, M.A, Kollman, J.M. | Deposit date: | 2021-04-16 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MH1
| Human CTPS2 bound to CTP | Descriptor: | CTP synthase 2, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION | Authors: | Lynch, E.M, Kollman, J.M. | Deposit date: | 2021-04-14 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MIF
| Human CTPS1 bound to inhibitor R80 | Descriptor: | CTP synthase 1, GLUTAMINE, MAGNESIUM ION, ... | Authors: | Lynch, E.M, Dimattia, M.A, Kollman, J.M. | Deposit date: | 2021-04-16 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MGZ
| Human CTPS1 bound to UTP, AMPPNP, and glutamine | Descriptor: | CTP synthase 1, GLUTAMINE, MAGNESIUM ION, ... | Authors: | Lynch, E.M, Dimattia, M.A, Kollman, J.M. | Deposit date: | 2021-04-14 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MIU
| Mouse CTPS2 bound to inhibitor R80 | Descriptor: | CTP synthase 2, GLUTAMINE, MAGNESIUM ION, ... | Authors: | Lynch, E.M, Dimattia, M.A, Kollman, J.M. | Deposit date: | 2021-04-17 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MIP
| Mouse CTPS1 bound to inhibitor R80 | Descriptor: | CTP synthase 1, GLUTAMINE, MAGNESIUM ION, ... | Authors: | Lynch, E.M, Dimattia, M.A, Kollman, J.M. | Deposit date: | 2021-04-17 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118, 2021
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6PK4
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6PDT
| cryoEM structure of yeast glucokinase filament | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Glucokinase-1, MAGNESIUM ION, ... | Authors: | Lynch, E.M, Dosey, A.M, Farrell, D.P, Stoddard, P.R, Kollman, J.M. | Deposit date: | 2019-06-19 | Release date: | 2020-03-11 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Polymerization in the actin ATPase clan regulates hexokinase activity in yeast. Science, 367, 2020
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6PK7
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7RER
| HUMAN IMPDH1 TREATED WITH ATP, IMP, AND NAD+ | Descriptor: | INOSINIC ACID, Isoform 5 of Inosine-5'-monophosphate dehydrogenase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Burrell, A.L, Kollman, J.M. | Deposit date: | 2021-07-13 | Release date: | 2022-01-12 | Last modified: | 2022-02-02 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | IMPDH1 retinal variants control filament architecture to tune allosteric regulation. Nat.Struct.Mol.Biol., 29, 2022
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7RFH
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7RGI
| HUMAN RETINAL VARIANT IMPDH1(546) TREATED WITH GTP, ATP, IMP, NAD+; INTERFACE-CENTERED | Descriptor: | INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Burrell, A.L, Kollman, J.M. | Deposit date: | 2021-07-15 | Release date: | 2022-01-12 | Last modified: | 2022-02-02 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | IMPDH1 retinal variants control filament architecture to tune allosteric regulation. Nat.Struct.Mol.Biol., 29, 2022
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