2BKK
| Crystal structure of Aminoglycoside Phosphotransferase APH(3')-IIIa in complex with the inhibitor AR_3a | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE, DESIGNED ANKYRIN REPEAT INHIBITOR AR_3A, ... | 著者 | Kohl, A, Amstutz, P, Parizek, P, Binz, H.K, Briand, C, Capitani, G, Forrer, P, Pluckthun, A, Grutter, M.G. | 登録日 | 2005-02-16 | 公開日 | 2005-08-09 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Allosteric Inhibition of Aminoglycoside Phosphotransferase by a Designed Ankyrin Repeat Protein Structure, 13, 2005
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1MJ0
| SANK E3_5: an artificial Ankyrin repeat protein | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SANK E3_5 Protein, SULFATE ION | 著者 | Kohl, A, Binz, H.K, Forrer, P, Stumpp, M.T, Plueckthun, A, Gruetter, M.G. | 登録日 | 2002-08-26 | 公開日 | 2003-01-21 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.031 Å) | 主引用文献 | Designed to be stable: Crystal structure of a consensus ankyrin repeat protein Proc.Natl.Acad.Sci.USA, 100, 2003
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3M99
| Structure of the Ubp8-Sgf11-Sgf73-Sus1 SAGA DUB module | 分子名称: | Protein SUS1, SAGA-associated factor 11, SAGA-associated factor 73, ... | 著者 | Kohler, A, Zimmerman, E, Schneider, M, Hurt, E, Zheng, N. | 登録日 | 2010-03-21 | 公開日 | 2010-05-05 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module. Cell(Cambridge,Mass.), 141, 2010
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4I9U
| Crystal structure of rabbit LDHA in complex with a fragment inhibitor AP26256 | 分子名称: | 6-({2-[(5-chloro-2-methoxyphenyl)amino]-2-oxoethyl}sulfanyl)pyridine-3-carboxylic acid, L-lactate dehydrogenase A chain | 著者 | Zhou, T, Kohlmann, A, Stephan, Z.G, Commodore, L, Greenfield, M.T, Zhu, X, Dalgarno, D.C. | 登録日 | 2012-12-05 | 公開日 | 2013-01-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J.Med.Chem., 56, 2013
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4I9H
| Crystal structure of rabbit LDHA in complex with AP28669 | 分子名称: | 1-O-[3-(5-carboxypyridin-2-yl)-5-fluorophenyl]-6-O-[4-({[(5-carboxypyridin-2-yl)sulfanyl]acetyl}amino)-2-chloro-5-methoxyphenyl]-D-mannitol, L-lactate dehydrogenase A chain | 著者 | Zhou, T, Stephan, Z.G, Kohlmann, A, Li, F, Commodore, L, Greenfield, M.T, Shakespeare, W.C, Zhu, X, Dalgarno, D.C. | 登録日 | 2012-12-05 | 公開日 | 2013-01-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J.Med.Chem., 56, 2013
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4I8X
| Crystal structure of rabbit LDHA in complex with AP27460 | 分子名称: | 6-phenylpyridine-3-carboxylic acid, L-lactate dehydrogenase A chain | 著者 | Zhou, T, Stephan, Z.G, Kohlmann, A, Li, F, Commodore, L, Greenfield, M.T, Zhu, X, Dalgarno, D.C. | 登録日 | 2012-12-04 | 公開日 | 2013-01-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J.Med.Chem., 56, 2013
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4I9N
| Crystal structure of rabbit LDHA in complex with AP28161 and AP28122 | 分子名称: | 6-({2-[(5-chloro-4-{[(2S)-2,3-dihydroxypropyl]oxy}-2-methoxyphenyl)amino]-2-oxoethyl}sulfanyl)pyridine-3-carboxylic acid, 6-[3-(carboxymethoxy)-5-fluorophenyl]pyridine-3-carboxylic acid, L-lactate dehydrogenase A chain | 著者 | Zhou, T, Kohlmann, A, Stephan, Z.G, Li, F, Commodore, L, Greenfield, M.T, Shakespeare, W.C, Zhu, X, Dalgarno, D.C. | 登録日 | 2012-12-05 | 公開日 | 2013-01-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors. J.Med.Chem., 56, 2013
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2BKG
| Crystal structure of E3_19 a designed ankyrin repeat protein | 分子名称: | SYNTHETIC CONSTRUCT ANKYRIN REPEAT PROTEIN E3_19 | 著者 | Binz, H.K, Kohl, A, Pluckthun, A, Grutter, M.G. | 登録日 | 2005-02-16 | 公開日 | 2006-06-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal Structure of a Consensus-Designed Ankyrin Repeat Protein: Implications for Stability Proteins: Struct., Funct., Bioinf., 65, 2006
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1SVX
| Crystal structure of a designed selected Ankyrin Repeat protein in complex with the Maltose Binding Protein | 分子名称: | Ankyrin Repeat Protein off7, Maltose-binding periplasmic protein | 著者 | Binz, H.K, Amstutz, P, Kohl, A, Stumpp, M.T, Briand, C, Forrer, P, Gruetter, M.G, Plueckthun, A. | 登録日 | 2004-03-30 | 公開日 | 2004-05-25 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | High-affinity binders selected from designed ankyrin repeat protein libraries NAT.BIOTECHNOL., 22, 2004
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2UUH
| Crystal structure of Human Leukotriene C4 Synthase in complex with substrate glutathione | 分子名称: | DODECYL-ALPHA-D-MALTOSIDE, GLUTATHIONE, LEUKOTRIENE C4 SYNTHASE, ... | 著者 | Martinez Molina, D, Wetterholm, A, Kohl, A, McCarthy, A.A, Niegowski, D, Ohlson, E, Hammarberg, T, Eshaghi, S, Haeggstrom, J.Z, Nordlund, P. | 登録日 | 2007-03-02 | 公開日 | 2007-07-17 | 最終更新日 | 2011-12-07 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural Basis for Synthesis of Inflammatory Mediators by Human Leukotriene C4 Synthase. Nature, 448, 2007
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2UUI
| Crystal structure of Human Leukotriene C4 Synthase | 分子名称: | DODECYL-BETA-D-MALTOSIDE, LEUKOTRIENE C4 SYNTHASE, NICKEL (II) ION, ... | 著者 | Martinez Molina, D, Wetterholm, A, Kohl, A, McCarthy, A.A, Niegowski, D, Ohlson, E, Hammarberg, T, Eshaghi, S, Haeggstrom, J.Z, Nordlund, P. | 登録日 | 2007-03-02 | 公開日 | 2007-07-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Basis for Synthesis of Inflammatory Mediators by Human Leukotriene C4 Synthase. Nature, 448, 2007
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2IUB
| Crystal structure of a divalent metal ion transporter CorA at 2.9 A resolution. | 分子名称: | CHLORIDE ION, DIVALENT CATION TRANSPORT-RELATED PROTEIN, MAGNESIUM ION | 著者 | Eshaghi, S, Niegowski, D, Kohl, A, Martinez Molina, D, Lesley, S.A, Nordlund, P. | 登録日 | 2006-06-01 | 公開日 | 2006-08-03 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal Structure of a Divalent Metal Ion Transporter Cora at 2.9 Angstrom Resolution. Science, 313, 2006
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1PN5
| NMR structure of the NALP1 Pyrin domain (PYD) | 分子名称: | NACHT-, LRR- and PYD-containing protein 2 | 著者 | Hiller, S, Kohl, A, Fiorito, F, Herrmann, T, Wider, G, Tschopp, J, Grutter, M.G, Wuthrich, K. | 登録日 | 2003-06-12 | 公開日 | 2003-10-07 | 最終更新日 | 2021-10-27 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain Structure, 11, 2003
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1G0U
| A GATED CHANNEL INTO THE PROTEASOME CORE PARTICLE | 分子名称: | MAGNESIUM ION, PROTEASOME COMPONENT C1, PROTEASOME COMPONENT C11, ... | 著者 | Groll, M, Bajorek, M, Kohler, A, Moroder, L, Rubin, D.M, Huber, R, Glickman, M.H, Finley, D. | 登録日 | 2000-10-09 | 公開日 | 2000-11-06 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A gated channel into the proteasome core particle. Nat.Struct.Biol., 7, 2000
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4TRQ
| Crystal structure of Sac3/Thp1/Sem1 | 分子名称: | 26S proteasome complex subunit SEM1, Nuclear mRNA export protein SAC3, Nuclear mRNA export protein THP1, ... | 著者 | Hellerschmied, D, Schneider, S, Kohler, A, Clausen, T. | 登録日 | 2014-06-17 | 公開日 | 2015-08-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression. Cell, 162, 2015
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3ZD6
| Snapshot 1 of RIG-I scanning on RNA duplex | 分子名称: | PROBABLE ATP-DEPENDENT RNA HELICASE DDX58, RNA DUPLEX, ZINC ION | 著者 | Luo, D, Pyle, A.M. | 登録日 | 2012-11-25 | 公開日 | 2013-08-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Defining the Functional Determinants for RNA Surveillance by Rig-I. Embo Rep., 14, 2013
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3ZD7
| Snapshot 3 of RIG-I scanning on RNA duplex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROBABLE ATP-DEPENDENT RNA HELICASE DDX58, ... | 著者 | Luo, D, Pyle, A.M. | 登録日 | 2012-11-25 | 公開日 | 2013-08-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Defining the Functional Determinants for RNA Surveillance by Rig-I. Embo Rep., 14, 2013
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6W44
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6W45
| Crystal structure of HAO1 in complex with biaryl acid inhibitor - compound 3 | 分子名称: | 2-chloranyl-4-[2-[[(6-chloranyl-1~{H}-indol-2-yl)carbonyl-methyl-amino]methyl]-5-fluoranyl-phenyl]benzoic acid, FLAVIN MONONUCLEOTIDE, Hydroxyacid oxidase 1 | 著者 | Ferguson, A.D. | 登録日 | 2020-03-10 | 公開日 | 2021-05-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening. J.Med.Chem., 64, 2021
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6W4C
| Crystal structure of HAO1 in complex with indazole acid inhibitor - compound 5 | 分子名称: | 5-[[3-[3-(dimethylamino)-1,2,4-oxadiazol-5-yl]-2-oxidanyl-phenyl]methylamino]-2~{H}-indazole-3-carboxylic acid, FLAVIN MONONUCLEOTIDE, Hydroxyacid oxidase 1 | 著者 | Ferguson, A.D. | 登録日 | 2020-03-10 | 公開日 | 2021-05-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening. J.Med.Chem., 64, 2021
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3KIK
| Sgf11:Sus1 complex | 分子名称: | Protein SUS1, SAGA-associated factor 11 | 著者 | Stewart, M, Ellisdon, A.M. | 登録日 | 2009-11-02 | 公開日 | 2009-12-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1 J.Biol.Chem., 285, 2010
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4U0I
| Crystal structure of KIT in complex with ponatinib | 分子名称: | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit, PHOSPHATE ION | 著者 | Zhou, T, Zhu, X, Dalgarno, D.C. | 登録日 | 2014-07-11 | 公開日 | 2014-10-08 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Ponatinib Inhibits Polyclonal Drug-Resistant KIT Oncoproteins and Shows Therapeutic Potential in Heavily Pretreated Gastrointestinal Stromal Tumor (GIST) Patients. Clin.Cancer Res., 20, 2014
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5Y63
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7T4J
| Crystal Structure of EGFR_D770_N771insNPG/V948R in complex with TAK-788 | 分子名称: | 1,2-ETHANEDIOL, CITRIC ACID, Epidermal growth factor receptor, ... | 著者 | Skene, R.J, Lane, W, Hu, Y. | 登録日 | 2021-12-10 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer. Bioorg.Med.Chem.Lett., 80, 2022
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7T4I
| Crystal Structure of wild type EGFR in complex with TAK-788 | 分子名称: | Epidermal growth factor receptor, propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | 著者 | Skene, R.J, Lane, W. | 登録日 | 2021-12-10 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer. Bioorg.Med.Chem.Lett., 80, 2022
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