3VSM
 
 | | The crystal structure of novel chondroition lyase ODV-E66, baculovirus envelope protein | | Descriptor: | GLYCEROL, Occlusion-derived virus envelope protein E66 | | Authors: | Kawaguchi, Y, Sugiura, N, Kimata, K, Kimura, M, Kakuta, Y. | | Deposit date: | 2012-04-27 | | Release date: | 2013-05-22 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The crystal structure of novel chondroition lyase ODV-E66, baculovirus envelope protein
To be Published
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3VSN
 | | The crystal structure of novel chondroition lyase ODV-E66, baculovirus envelope protein | | Descriptor: | GLYCEROL, IODIDE ION, Occlusion-derived virus envelope protein E66 | | Authors: | Kawaguchi, Y, Sugiura, N, Kimata, K, Kimura, M, Kakuta, Y. | | Deposit date: | 2012-04-27 | | Release date: | 2013-05-22 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The crystal structure of novel chondroition lyase ODV-E66, baculovirus envelope protein
To be Published
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2Z87
 | | Crystal structure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GalNAc and UDP | | Descriptor: | Chondroitin synthase, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ... | | Authors: | Osawa, T, Sugiura, N, Shimada, H, Hirooka, R, Tsuji, A, Kimura, M, Kimata, K, Kakuta, Y. | | Deposit date: | 2007-09-03 | | Release date: | 2008-09-16 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of chondroitin polymerase from Escherichia coli K4.
Biochem. Biophys. Res. Commun., 378, 2009
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2Z86
 | | Crystal structure of chondroitin polymerase from Escherichia coli strain K4 (K4CP) complexed with UDP-GlcUA and UDP | | Descriptor: | Chondroitin synthase, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ... | | Authors: | Osawa, T, Sugiura, N, Shimada, H, Hirooka, R, Tsuji, A, Kimura, M, Kimata, K, Kakuta, Y. | | Deposit date: | 2007-09-03 | | Release date: | 2008-09-16 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of chondroitin polymerase from Escherichia coli K4.
Biochem. Biophys. Res. Commun., 378, 2009
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6ACR
 | | Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK-59638 | | Descriptor: | Activin receptor type-1, N-(4-methoxyphenyl)-4-[3-(pyridin-3-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine, SULFATE ION | | Authors: | Sakai, N, Mishima-Tsumagari, C, Matsumoto, T, Shirouzu, M. | | Deposit date: | 2018-07-27 | | Release date: | 2019-03-20 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H).
Chem. Pharm. Bull., 67, 2019
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7C3G
 | | Crystal structure of human ALK2 kinase domain with R206H mutation in complex with a bicyclic pyrazole inhibitor RK-73134 | | Descriptor: | 1,2-ETHANEDIOL, Activin receptor type-1, SULFATE ION, ... | | Authors: | Sakai, N, Mishima-Tsumagari, C, Matsumoto, T, Shirouzu, M. | | Deposit date: | 2020-05-12 | | Release date: | 2021-03-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.802 Å) | | Cite: | Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva.
Bioorg.Med.Chem.Lett., 38, 2021
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6JUX
 | | Crystal structure of human ALK2 kinase domain with R206H mutation in complex with RK-71807 | | Descriptor: | 4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{N}-(4-piperazin-1-ylphenyl)pyrimidin-2-amine, Activin receptor type-1, SULFATE ION | | Authors: | Sakai, N, Mishima-Tsumagari, C, Matsumoto, T, Shirouzu, M. | | Deposit date: | 2019-04-15 | | Release date: | 2020-04-15 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches.
Acs Omega, 5, 2020
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