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Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain
Descriptor:	E1 glycoprotein, E2 glycoprotein, E3, ...
Authors:	Miller, A.S, Kuhn, R.J.
Deposit date:	2020-02-29
Release date:	2020-08-26
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (5.3 Å)
Cite:	Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site. Cell Host Microbe, 28, 2020

6W1C

Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain
Descriptor:	E1 glycoprotein, E2 glycoprotein, Fab CHK-265 heavy chain, ...
Authors:	Miller, A.S, Kuhn, R.J.
Deposit date:	2020-03-04
Release date:	2020-08-26
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (5.3 Å)
Cite:	Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site. Cell Host Microbe, 28, 2020

6VYV

Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain
Descriptor:	E1 glycoprotein, E2 glycoprotein, Fab CHK-265 heavy chain, ...
Authors:	Miller, A.S, Kuhn, R.J.
Deposit date:	2020-02-27
Release date:	2020-08-26
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (6.33 Å)
Cite:	Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site. Cell Host Microbe, 28, 2020

7N1I

CryoEM structure of Venezuelan equine encephalitis virus VLP
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid, E1 envelope glycoprotein, ...
Authors:	Basore, K, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:	2021-05-27
Release date:	2021-10-13
Last modified:	2021-11-10
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Structure of Venezuelan equine encephalitis virus in complex with the LDLRAD3 receptor. Nature, 598, 2021

7N1H

CryoEM structure of Venezuelan equine encephalitis virus VLP in complex with the LDLRAD3 receptor
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Capsid, ...
Authors:	Basore, K, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:	2021-05-27
Release date:	2021-10-13
Last modified:	2021-11-10
Method:	ELECTRON MICROSCOPY (4.3 Å)
Cite:	Structure of Venezuelan equine encephalitis virus in complex with the LDLRAD3 receptor. Nature, 598, 2021

7N6A

Pre-fusion state 1 of EEEV with localized reconstruction
Descriptor:	Spike glycoprotein E1, Spike glycoprotein E2
Authors:	Chen, C.-L, Kuhn, R.J, Klose, T.
Deposit date:	2021-06-07
Release date:	2022-06-22
Last modified:	2022-08-03
Method:	ELECTRON MICROSCOPY (14.3 Å)
Cite:	Cryo-EM structures of alphavirus conformational intermediates in low pH-triggered prefusion states. Proc.Natl.Acad.Sci.USA, 119, 2022

7N69

Pre-fusion state 2 of EEEV with localized reconstruction
Descriptor:	Spike glycoprotein E1, Spike glycoprotein E2
Authors:	Chen, C.-L, Kuhn, R.J, Klose, T.
Deposit date:	2021-06-07
Release date:	2022-06-22
Last modified:	2022-08-03
Method:	ELECTRON MICROSCOPY (14.1 Å)
Cite:	Cryo-EM structures of alphavirus conformational intermediates in low pH-triggered prefusion states. Proc.Natl.Acad.Sci.USA, 119, 2022

8DAN

CryoEM structure of Western equine encephalitis virus VLP in complex with the avian MXRA8 receptor
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, E1 envelope glycoprotein, E2 envelope glycoprotein, ...
Authors:	Zimmerman, M.I, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:	2022-06-13
Release date:	2023-12-20
Method:	ELECTRON MICROSCOPY (4.74 Å)
Cite:	Alternate domain repeat usage in an alphavirus entry receptor enables host species expansion To Be Published

8DAQ

CryoEM structure of Western equine encephalitis virus VLP
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, E1 envelope glycoprotein, E2 envelope glycoprotein
Authors:	Zimmerman, M.I, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:	2022-06-13
Release date:	2023-12-20
Method:	ELECTRON MICROSCOPY (4.35 Å)
Cite:	Alternate repeat domain usage in an alphavirus entry receptor enables host species expansion To Be Published

6NK5

Electron Cryo-Microscopy Of Chikungunya VLP
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein, E1 glycoprotein, ...
Authors:	Basore, K, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:	2019-01-04
Release date:	2019-05-22
Last modified:	2020-07-29
Method:	ELECTRON MICROSCOPY (4.16 Å)
Cite:	Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor. Cell, 177, 2019

6O3G

Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41).
Descriptor:	GLYCEROL, MEPER peptide, region 671-683 of HIV-1 gp41, ...
Authors:	Irimia, A, Wilson, I.A.
Deposit date:	2019-02-26
Release date:	2019-12-04
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (3.645 Å)
Cite:	An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nat Commun, 10, 2019

6O3K

Crystal structure of the unbound Fab fragment of the human HIV-1 neutralizing antibody PGZL1.H4K3
Descriptor:	GLYCEROL, PGZL1.H4K3 heavy chain, PGZL1.H4K3 light chain, ...
Authors:	Irimia, A, Wilson, I.A.
Deposit date:	2019-02-26
Release date:	2019-12-04
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.451 Å)
Cite:	An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nat Commun, 10, 2019

6O3D

Crystal structure of the unbound Fab fragment of the human HIV-1 neutralizing antibody PGZL1.
Descriptor:	GLYCEROL, PGZL1 FAB HEAVY CHAIN, PGZL1 FAB LIGHT CHAIN, ...
Authors:	Irimia, A, Wilson, I.A.
Deposit date:	2019-02-26
Release date:	2019-12-04
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.402 Å)
Cite:	An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nat Commun, 10, 2019

6O3J

Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41) and phosphatidic acid (06:0 PA)
Descriptor:	(2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, (4S)-2-METHYL-2,4-PENTANEDIOL, MPER peptide, ...
Authors:	Irimia, A, Wilson, I.A.
Deposit date:	2019-02-26
Release date:	2019-12-04
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (3.416 Å)
Cite:	An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nat Commun, 10, 2019

6O3L

Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1.H4K3 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41).
Descriptor:	GLYCEROL, MPER peptide, region 671-683 of HIV-1 gp41, ...
Authors:	Irimia, A, Wilson, I.A.
Deposit date:	2019-02-26
Release date:	2019-12-04
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.98 Å)
Cite:	An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nat Commun, 10, 2019

6O41

Crystal structure of the unbound PGZL1 germline Fab fragment (PGZL1_gVmDmJ)
Descriptor:	GLYCEROL, Immunoglobulin G-binding protein G (DOMAIN III), germline PGZL1_gVmDmJ heavy chain, ...
Authors:	Irimia, A, Wilson, I.A.
Deposit date:	2019-02-27
Release date:	2019-12-04
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.465 Å)
Cite:	An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nat Commun, 10, 2019

6O3U

Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1.H4K3 in complex with 06:0 PA
Descriptor:	(2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, GLYCEROL, PGZL1.H4K3 heavy chain, ...
Authors:	Irimia, A, Wilson, I.A.
Deposit date:	2019-02-27
Release date:	2019-12-04
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (3.105 Å)
Cite:	An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nat Commun, 10, 2019

6O42

Crystal structure of the germline PGZL1 (PGZL1_gVmDmJ) Fab in complex with MPER peptide epitope.
Descriptor:	GLYCEROL, MPER peptide, region 671-683 of HIV-1 gp41, ...
Authors:	Irimia, A, Wilson, I.A.
Deposit date:	2019-02-27
Release date:	2019-12-04
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nat Commun, 10, 2019

8EWF

CryoEM structure of Western equine encephalitis virus VLP in complex with the avian MXRA8 receptor
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Chimeric MXRA8 receptor: D1 from Duck MXRA8 and D2 from Mouse MXRA8, E1 envelope protein, ...
Authors:	Zimmerman, M.I, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:	2022-10-22
Release date:	2023-10-25
Method:	ELECTRON MICROSCOPY (3.92 Å)
Cite:	Alternate domain repeat usage in an alphavirus entry receptor enables host species expansion To Be Published

5AWN

Crystal structure of Human anti-HIV-1 broadly neutralizing antibody 3BC176 Fab
Descriptor:	Heavy chain of 3BC176 Fab, Light chain of 3BC176 Fab
Authors:	Lee, J.H, Wilson, I.A, Ward, A.B.
Deposit date:	2015-07-06
Release date:	2015-11-11
Last modified:	2023-11-08
Method:	X-RAY DIFFRACTION (1.887 Å)
Cite:	Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike. Nat Commun, 6, 2015

7SFW

CryoEM structure of Venezuelan Equine Encephalitis virus (VEEV) TC-83 strain VLP in complex with Fab hVEEV-63 (focus refine of the asymmetric unit)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein, Spike glycoprotein E1, ...
Authors:	Binshtein, E, Crowe, J.E.
Deposit date:	2021-10-04
Release date:	2022-03-16
Last modified:	2022-07-06
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge. J.Exp.Med., 219, 2022

7SFU

CryoEM structure of Venezuelan Equine Encephalitis virus (VEEV) TC-83 strain VLP
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein, Spike glycoprotein E1, ...
Authors:	Binshtein, E, Crowe, J.E.
Deposit date:	2021-10-04
Release date:	2022-03-16
Last modified:	2022-07-06
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge. J.Exp.Med., 219, 2022

7SFV

CryoEM structure of Venezuelan Equine Encephalitis virus (VEEV) TC-83 strain VLP in complex with Fab hVEEV-63
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein, Spike glycoprotein E1, ...
Authors:	Binshtein, E, Crowe, J.E.
Deposit date:	2021-10-04
Release date:	2022-03-16
Last modified:	2022-07-06
Method:	ELECTRON MICROSCOPY (4 Å)
Cite:	Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge. J.Exp.Med., 219, 2022

5CCK

Crystal structure of Human anti-HIV-1 broadly neutralizing antibody 3BC315 Fab
Descriptor:	3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Antibody 3BC315 Fab heavy chain, Antibody 3BC315 Fab light chain
Authors:	Lee, J.H, Ward, A.B, Wilson, I.A.
Deposit date:	2015-07-02
Release date:	2015-10-07
Last modified:	2019-12-11
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike. Nat Commun, 6, 2015

6C74

Crystal Structure of Murine CD300lf in complex with phosphocholine
Descriptor:	CALCIUM ION, CMRF35-like molecule-1, PHOSPHOCHOLINE
Authors:	Nelson, C.A, Fremont, D.H.
Deposit date:	2018-01-19
Release date:	2018-09-12
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.358 Å)
Cite:	Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor. Proc. Natl. Acad. Sci. U.S.A., 115, 2018

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