6O3G

Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41).

Summary for 6O3G

Entry DOI	10.2210/pdb6o3g/pdb
Related	6O3D 6O3J 6O3K 6O3L 6O3U 6O41 6O42
Descriptor	PGZL1 light chain, PGZL1 heavy chain, MEPER peptide, region 671-683 of HIV-1 gp41, ... (5 entities in total)
Functional Keywords	pgzl1 anti hiv-1, gp41 mper, membrane lipids, broadly neutralising hiv-1 antibody, immune system
Biological source	Homo sapiens More
Total number of polymer chains	12
Total formula weight	198085.35
Authors	Irimia, A.,Wilson, I.A. (deposition date: 2019-02-26, release date: 2019-12-04, Last modification date: 2023-10-11)
Primary citation	Zhang, L.,Irimia, A.,He, L.,Landais, E.,Rantalainen, K.,Leaman, D.P.,Vollbrecht, T.,Stano, A.,Sands, D.I.,Kim, A.S.,Poignard, P.,Burton, D.R.,Murrell, B.,Ward, A.B.,Zhu, J.,Wilson, I.A.,Zwick, M.B. An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nat Commun, 10:5389-5389, 2019 Cited by PubMed: 31772165 DOI: 10.1038/s41467-019-12973-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.645 Å)

Structure validation