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7OPL
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BU of 7opl by Molmil
CryoEM structure of DNA Polymerase alpha - primase bound to SARS CoV nsp1
分子名称: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase large subunit, ...
著者Kilkenny, M.L, Pellegrini, L.
登録日2021-06-01
公開日2021-11-10
最終更新日2022-02-16
実験手法ELECTRON MICROSCOPY (4.12 Å)
主引用文献Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with DNA polymerase alpha-primase.
Protein Sci., 31, 2022
2VXB
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BU of 2vxb by Molmil
Structure of the Crb2-BRCT2 domain
分子名称: DNA REPAIR PROTEIN RHP9, PRASEODYMIUM ION
著者Kilkenny, M.L, Roe, S.M, Pearl, L.H.
登録日2008-07-03
公開日2008-08-12
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and Functional Analysis of the Crb2-Brct2 Domain Reveals Distinct Roles in Checkpoint Signaling and DNA Damage Repair.
Genes Dev., 22, 2008
2VXC
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BU of 2vxc by Molmil
Structure of the Crb2-BRCT2 domain complex with phosphopeptide.
分子名称: DNA REPAIR PROTEIN RHP9, H2A1 PEPTIDE, PRASEODYMIUM ION
著者Kilkenny, M.L, Roe, S.M, Pearl, L.H.
登録日2008-07-03
公開日2008-08-12
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural and Functional Analysis of the Crb2-Brct2 Domain Reveals Distinct Roles in Checkpoint Signaling and DNA Damage Repair.
Genes Dev., 22, 2008
4BPX
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BU of 4bpx by Molmil
Crystal structure of human primase in complex with the primase- binding motif of DNA polymerase alpha
分子名称: DNA POLYMERASE ALPHA CATALYTIC SUBUNIT, DNA PRIMASE LARGE SUBUNIT, DNA PRIMASE SMALL SUBUNIT, ...
著者Kilkenny, M.L, Perera, R.L, Pellegrini, L.
登録日2013-05-28
公開日2013-09-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
Proc.Natl.Acad.Sci.USA, 110, 2013
4BPU
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BU of 4bpu by Molmil
Crystal structure of human primase in heterodimeric form, comprising PriS and truncated PriL lacking the C-terminal Fe-S domain.
分子名称: DNA PRIMASE LARGE SUBUNIT, DNA PRIMASE SMALL SUBUNIT, GLYCEROL, ...
著者Kilkenny, M.L, Perera, R.L, Pellegrini, L.
登録日2013-05-28
公開日2013-09-25
最終更新日2013-10-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
Proc.Natl.Acad.Sci.USA, 110, 2013
4BPW
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BU of 4bpw by Molmil
Crystal structure of human primase bound to UTP
分子名称: DNA PRIMASE LARGE SUBUNIT, DNA PRIMASE SMALL SUBUNIT, MAGNESIUM ION, ...
著者Kilkenny, M.L, Perera, R.L, Pellegrini, L.
登録日2013-05-28
公開日2013-09-25
最終更新日2013-10-16
実験手法X-RAY DIFFRACTION (3.003 Å)
主引用文献Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
Proc.Natl.Acad.Sci.USA, 110, 2013
6R4T
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BU of 6r4t by Molmil
Crystal structure of the Pri1 subunit of human primase bound to vidarabine triphosphate
分子名称: 1,2-ETHANEDIOL, 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-9H-purin-6-amine, DNA primase small subunit, ...
著者Kilkenny, M.L, Pellegrini, L.
登録日2019-03-24
公開日2019-09-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6RB4
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BU of 6rb4 by Molmil
Crystal structure of the Pri1 subunit of human primase
分子名称: 1,2-ETHANEDIOL, DNA primase small subunit, ZINC ION
著者Kilkenny, M.L, Pellegrini, L.
登録日2019-04-09
公開日2019-09-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6R5E
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BU of 6r5e by Molmil
Crystal structure of the Pri1 subunit of human primase bound to 2F-ATP
分子名称: 1,2-ETHANEDIOL, 2-fluoro-ATP, DNA primase small subunit, ...
著者Kilkenny, M.L, Pellegrini, L.
登録日2019-03-24
公開日2019-09-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6R4U
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BU of 6r4u by Molmil
Crystal structure of the Pri1 subunit of human primase bound to fludarabine triphosphate
分子名称: 1,2-ETHANEDIOL, 2-fluoro-9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-9H-purin-6-a mine, DNA primase small subunit, ...
著者Kilkenny, M.L, Pellegrini, L.
登録日2019-03-24
公開日2019-09-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6R5D
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BU of 6r5d by Molmil
Crystal structure of the Pri1 subunit of human primase bound to dATP
分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA primase small subunit, ...
著者Kilkenny, M.L, Pellegrini, L.
登録日2019-03-24
公開日2019-09-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6R4S
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BU of 6r4s by Molmil
Crystal structure of the Pri1 subunit of human primase bound to ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA primase small subunit, MANGANESE (II) ION, ...
著者Kilkenny, M.L, Pellegrini, L.
登録日2019-03-24
公開日2019-09-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
3TM7
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BU of 3tm7 by Molmil
Processed Aspartate Decarboxylase Mutant with Asn72 mutated to Ala
分子名称: Aspartate 1-decarboxylase alpha chain, Aspartate 1-decarboxylase beta chain, SULFATE ION
著者Webb, M.E, Lobley, C.M.C, Soliman, F, Kilkenny, M.L, Smith, A.G, Abell, C, Blundell, T.L.
登録日2011-08-31
公開日2012-04-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of Escherichia coli aspartate alpha-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation
Acta Crystallogr.,Sect.F, 68, 2012
5MQI
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BU of 5mqi by Molmil
Crystal structure of the N-terminal domain of human Timeless
分子名称: Protein timeless homolog,Protein timeless homolog, SULFATE ION
著者Holzer, S, Kilkenny, M.L, Pellegrini, L.
登録日2016-12-20
公開日2017-03-08
最終更新日2017-05-31
実験手法X-RAY DIFFRACTION (1.847 Å)
主引用文献Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin.
Nucleic Acids Res., 45, 2017
4WWM
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BU of 4wwm by Molmil
X-ray crystal structure of Sulfolobus solfataricus Urm1
分子名称: SULFATE ION, Uncharacterized protein
著者Bray, S.M, Anjum, S.R, Blackwood, J.K, Kilkenny, M.L, Coelho, M.A, Foster, B.M, Pellegrini, L, Robinson, N.P.
登録日2014-11-11
公開日2015-09-23
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Involvement of a eukaryotic-like ubiquitin-related modifier in the proteasome pathway of the archaeon Sulfolobus acidocaldarius.
Nat Commun, 6, 2015
3G65
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BU of 3g65 by Molmil
Crystal Structure of the Human Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex
分子名称: Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1, Checkpoint protein HUS1
著者Dore, A.S, Kilkenny, M.L, Rzechorzek, N.J, Pearl, L.H.
登録日2009-02-06
公開日2009-05-26
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of the rad9-rad1-hus1 DNA damage checkpoint complex--implications for clamp loading and regulation.
Mol.Cell, 34, 2009
4FXD
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BU of 4fxd by Molmil
Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA
分子名称: DNA (5'-D(*TP*TP*TP*TP*CP*GP*CP*TP*GP*CP*CP*CP*GP*CP*CP*T)-3'), DNA polymerase alpha catalytic subunit A, RNA (5'-R(*AP*GP*GP*CP*GP*GP*GP*CP*AP*G)-3')
著者Perera, R.L, Torella, R, Klinge, S, Kilkenny, M.L, Maman, J.D, Pellegrini, L.
登録日2012-07-03
公開日2013-02-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Mechanism for priming DNA synthesis by yeast DNA Polymerase alpha
eLife, 2, 2013
6TAZ
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BU of 6taz by Molmil
Timeless couples G quadruplex detection with processing by DDX11 during DNA replication
分子名称: Protein timeless homolog
著者Lerner Koch, L, Holzer, S, Kilkenny, M.L, Murat, P, Svikovic, S, Schiavone, D, Bittleston, A, Maman, J.D, Branzei, D, Stott, K, Pellegrini, L, Sale, E.J.
登録日2019-10-31
公開日2020-07-01
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.
Embo J., 39, 2020
4AZD
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BU of 4azd by Molmil
T57V mutant of aspartate decarboxylase
分子名称: ASPARTATE 1-DECARBOXYLASE, MALONATE ION
著者Webb, M.E, Yorke, B.A, Kershaw, T, Lovelock, S, Lobley, C.M.C, Kilkenny, M.L, Smith, A.G, Blundell, T.L, Pearson, A.R, Abell, C.
登録日2012-06-25
公開日2012-07-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Threonine 57 is Required for the Post-Translational Activation of Escherichia Coli Aspartate Alpha-Decarboxylase
Acta Crystallogr.,Sect.D, 70, 2014
4BA9
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BU of 4ba9 by Molmil
The structural basis for the coordination of Y-family Translesion DNA Polymerases by Rev1
分子名称: DNA POLYMERASE KAPPA, DNA REPAIR PROTEIN REV1, MAGNESIUM ION, ...
著者Grummitt, C.G, Kilkenny, M.L, Frey, A, Roe, S.M, Oliver, A.W, Sale, J.E, Pearl, L.H.
登録日2012-09-12
公開日2013-09-25
最終更新日2017-03-15
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献The Structural Basis for the Coordination of Y- Family Translesion DNA Polymerases by Rev1
To be Published
4B08
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BU of 4b08 by Molmil
Yeast DNA polymerase alpha, Selenomethionine protein
分子名称: DNA POLYMERASE ALPHA CATALYTIC SUBUNIT A
著者Perera, R.L, Torella, R, Klinge, S, Kilkenny, M.L, Maman, J.D, Pellegrini, L.
登録日2012-06-29
公開日2013-02-27
最終更新日2013-05-01
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Mechanism for Priming DNA Synthesis by Yeast DNA Polymerase Alpha
Elife, 2, 2013
2IZO
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BU of 2izo by Molmil
Structure of an Archaeal PCNA1-PCNA2-FEN1 Complex
分子名称: DNA POLYMERASE SLIDING CLAMP B, DNA POLYMERASE SLIDING CLAMP C, FLAP STRUCTURE-SPECIFIC ENDONUCLEASE, ...
著者Dore, A.S, Kilkenny, M.L, Roe, S.M, Pearl, L.H.
登録日2006-07-25
公開日2006-09-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of an Archaeal PCNA1-PCNA2-Fen1 Complex: Elucidating PCNA Subunit and Client Enzyme Specificity.
Nucleic Acids Res., 34, 2006
1PQF
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BU of 1pqf by Molmil
Glycine 24 to Serine mutation of aspartate decarboxylase
分子名称: Aspartate 1-decarboxylase, SULFATE ION
著者Schmitzberger, F, Kilkenny, M.L, Lobley, C.M.C, Webb, M.E, Vinkovic, M, Matak-Vinkovic, D, Witty, M, Chirgadze, D.Y, Smith, A.G, Abell, C, Blundell, T.L.
登録日2003-06-18
公開日2003-11-18
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1PPY
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BU of 1ppy by Molmil
Native precursor of pyruvoyl dependent Aspartate decarboxylase
分子名称: Aspartate 1-decarboxylase precursor, SULFATE ION
著者Schmitzberger, F, Kilkenny, M.L, Lobley, C.M.C, Webb, M.E, Vinkovic, M, Matak-Vinkovic, D, Witty, M, Chirgadze, D.Y, Smith, A.G, Abell, C, Blundell, T.L.
登録日2003-06-17
公開日2003-11-18
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003
1PYQ
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BU of 1pyq by Molmil
Unprocessed Aspartate Decarboxylase Mutant, with Alanine inserted at position 24
分子名称: Aspartate 1-decarboxylase, SULFATE ION
著者Schmitzberger, F, Kilkenny, M.L, Lobley, C.M.C, Webb, M.E, Vinkovic, M, Matak-Vinkovic, D, Witty, M, Chirgadze, D.Y, Smith, A.G, Abell, C, Blundell, T.L.
登録日2003-07-09
公開日2003-11-18
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Constraints on protein self-processing in L-aspartate-alpha-decarboxylase
Embo J., 22, 2003

 

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