1G0V
 
 | | THE STRUCTURE OF PROTEINASE A COMPLEXED WITH A IA3 MUTANT, MVV | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEASE A INHIBITOR 3, PROTEINASE A, ... | | 著者 | Phylip, L.H, Lees, W, Brownsey, B.G, Bur, D, Dunn, B.M, Winther, J, Gustchina, A, Li, M, Copeland, T, Wlodawer, A, Kay, J. | | 登録日 | 2000-10-09 | | 公開日 | 2001-04-21 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae.
J.Biol.Chem., 276, 2001
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1FMU
 | | STRUCTURE OF NATIVE PROTEINASE A IN P3221 SPACE GROUP. | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, SACCHAROPEPSIN, ... | | 著者 | Gustchina, A, Li, M, Phylip, L.H, Lees, W.E, Kay, J, Wlodawer, A. | | 登録日 | 2000-08-18 | | 公開日 | 2002-07-31 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae.
Biochem.Biophys.Res.Commun., 295, 2002
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1FMX
 | | STRUCTURE OF NATIVE PROTEINASE A IN THE SPACE GROUP P21 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SACCHAROPEPSIN, ... | | 著者 | Gustchina, A, Li, M, Phylip, L.H, Lees, W.E, Kay, J, Wlodawer, A. | | 登録日 | 2000-08-18 | | 公開日 | 2002-07-31 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae.
Biochem.Biophys.Res.Commun., 295, 2002
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1DPJ
 | | THE STRUCTURE OF PROTEINASE A COMPLEXED WITH IA3 PEPTIDE INHIBITOR | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEINASE A, PROTEINASE INHIBITOR IA3 PEPTIDE, ... | | 著者 | Li, M, Phylip, H.L, Lees, W.E, Winther, J.R, Dunn, B.M, Wlodawer, A, Kay, J, Guschina, A. | | 登録日 | 1999-12-27 | | 公開日 | 2000-05-03 | | 最終更新日 | 2021-07-07 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix.
Nat.Struct.Biol., 7, 2000
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1DP5
 | | THE STRUCTURE OF PROTEINASE A COMPLEXED WITH A IA3 MUTANT INHIBITOR | | 分子名称: | PROTEINASE A, PROTEINASE INHIBITOR IA3, beta-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Li, M, Phylip, H.L, Lees, W.E, Winther, J.R, Dunn, B.M, Wlodawer, A, Kay, J, Guschina, A. | | 登録日 | 1999-12-23 | | 公開日 | 2000-05-03 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix.
Nat.Struct.Biol., 7, 2000
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4ER4
 | | HIGH-RESOLUTION X-RAY ANALYSES OF RENIN INHIBITOR-ASPARTIC PROTEINASE COMPLEXES | | 分子名称: | ENDOTHIAPEPSIN, H-142 | | 著者 | Foundling, S.I, Watson, F.E, Szelke, M, Blundell, T.L. | | 登録日 | 1991-01-05 | | 公開日 | 1991-04-15 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes.
Nature, 327, 1987
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4FIV
 | | FIV PROTEASE COMPLEXED WITH AN INHIBITOR LP-130 | | 分子名称: | 4-[2-(2-ACETYLAMINO-3-NAPHTALEN-1-YL-PROPIONYLAMINO)-4-METHYL-PENTANOYLAMINO]-3-HYDROXY-6-METHYL-HEPTANOIC ACID [1-(1-CARBAMOYL-2-NAPHTHALEN-1-YL-ETHYLCARBAMOYL)-PROPYL]-AMIDE, FELINE IMMUNODEFICIENCY VIRUS PROTEASE | | 著者 | Kervinen, J, Lubkowski, J, Zdanov, A, Wlodawer, A, Gustchina, A. | | 登録日 | 1998-07-15 | | 公開日 | 1999-01-13 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV.
Protein Sci., 7, 1998
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1KA7
 | | SAP/SH2D1A bound to peptide n-Y-c | | 分子名称: | SH2 DOMAIN PROTEIN 1A, peptide n-Y-c | | 著者 | Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. | | 登録日 | 2001-10-31 | | 公開日 | 2001-11-07 | | 最終更新日 | 2021-10-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
EMBO J., 21, 2002
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1KA6
 | | SAP/SH2D1A bound to peptide n-pY | | 分子名称: | SH2 DOMAIN PROTEIN 1A, peptide n-pY | | 著者 | Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. | | 登録日 | 2001-10-31 | | 公開日 | 2001-11-07 | | 最終更新日 | 2021-10-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
EMBO J., 21, 2002
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2ER9
 | | X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES. | | 分子名称: | ENDOTHIAPEPSIN, L363,564 | | 著者 | Cooper, J.B, Foundling, S.I, Boger, J, Blundell, T.L. | | 登録日 | 1990-10-20 | | 公開日 | 1991-01-15 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | X-ray studies of aspartic proteinase-statine inhibitor complexes.
Biochemistry, 28, 1989
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2ER0
 | | X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES | | 分子名称: | ENDOTHIAPEPSIN, L364,099 | | 著者 | Cooper, J.B, Foundling, S.I, Boger, J, Blundell, T.L. | | 登録日 | 1990-10-20 | | 公開日 | 1991-01-15 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | X-ray studies of aspartic proteinase-statine inhibitor complexes.
Biochemistry, 28, 1989
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2MX4
 | | NMR structure of Phosphorylated 4E-BP2 | | 分子名称: | Eukaryotic translation initiation factor 4E-binding protein 2 | | 著者 | Bah, A, Forman-Kay, J, Vernon, R, Siddiqui, Z, Krzeminski, M, Muhandiram, R, Zhao, C, Sonenberg, N, Kay, L. | | 登録日 | 2014-12-10 | | 公開日 | 2015-01-07 | | 最終更新日 | 2015-03-18 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.
Nature, 519, 2015
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3V7D
 | | Crystal Structure of ScSkp1-ScCdc4-pSic1 peptide complex | | 分子名称: | Cell division control protein 4, Protein SIC1, Suppressor of kinetochore protein 1 | | 著者 | Tang, X, Orlicky, S, Mittag, T, Csizmok, V, Pawson, T, Forman-Kay, J, Sicheri, F, Tyers, M. | | 登録日 | 2011-12-20 | | 公開日 | 2012-05-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.306 Å) | | 主引用文献 | Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase.
Proc.Natl.Acad.Sci.USA, 109, 2012
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2FMB
 | | EIAV PROTEASE COMPLEXED WITH AN INHIBITOR LP-130 | | 分子名称: | 4-[2-(2-ACETYLAMINO-3-NAPHTALEN-1-YL-PROPIONYLAMINO)-4-METHYL-PENTANOYLAMINO]-3-HYDROXY-6-METHYL-HEPTANOIC ACID [1-(1-CARBAMOYL-2-NAPHTHALEN-1-YL-ETHYLCARBAMOYL)-PROPYL]-AMIDE, EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE | | 著者 | Kervinen, J, Lubkowski, J, Zdanov, A, Wlodawer, A, Gustchina, A. | | 登録日 | 1998-07-13 | | 公開日 | 1999-01-13 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV.
Protein Sci., 7, 1998
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1ODY
 | | HIV-1 PROTEASE COMPLEXED WITH AN INHIBITOR LP-130 | | 分子名称: | 4-[2-(2-ACETYLAMINO-3-NAPHTALEN-1-YL-PROPIONYLAMINO)-4-METHYL-PENTANOYLAMINO]-3-HYDROXY-6-METHYL-HEPTANOIC ACID [1-(1-CARBAMOYL-2-NAPHTHALEN-1-YL-ETHYLCARBAMOYL)-PROPYL]-AMIDE, HIV-1 PROTEASE | | 著者 | Kervinen, J, Lubkowski, J, Zdanov, A, Wlodawer, A, Gustchina, A. | | 登録日 | 1998-07-13 | | 公開日 | 1999-02-16 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV.
Protein Sci., 7, 1998
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2RPN
 | | A crucial role for high intrinsic specificity in the function of yeast SH3 domains | | 分子名称: | Actin-binding protein, Actin-regulating kinase 1 | | 著者 | Stollar, E.J, Garcia, B, Chong, A, Forman-Kay, J, Davidson, A. | | 登録日 | 2008-06-12 | | 公開日 | 2009-06-16 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural, functional, and bioinformatic studies demonstrate the crucial role of an extended peptide binding site for the SH3 domain of yeast Abp1p
J.Biol.Chem., 284, 2009
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1FMB
 | | EIAV PROTEASE COMPLEXED WITH THE INHIBITOR HBY-793 | | 分子名称: | EIAV PROTEASE, [2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYL-VALINYL]-PHENYLALANINOL | | 著者 | Wlodawer, A, Gustchina, A, Zdanov, A, Kervinen, J. | | 登録日 | 1996-02-27 | | 公開日 | 1996-10-14 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of equine infectious anemia virus proteinase complexed with an inhibitor.
Protein Sci., 5, 1996
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2K6D
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1PFZ
 | | PROPLASMEPSIN II FROM PLASMODIUM FALCIPARUM | | 分子名称: | GLYCEROL, PROPLASMEPSIN II | | 著者 | Bernstein, N.K, Cherney, M.M, Loetscher, H, Ridley, R.G, James, M.N.G. | | 登録日 | 1998-07-07 | | 公開日 | 1999-01-13 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum.
Nat.Struct.Biol., 6, 1999
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1HXB
 | | HIV-1 proteinase complexed with RO 31-8959 | | 分子名称: | (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, HIV-1 PROTEASE | | 著者 | Graves, B.J, Hatada, M.H, Crowther, R.L. | | 登録日 | 1996-09-13 | | 公開日 | 1997-03-12 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere.
J.Med.Chem., 34, 1991
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