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Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2
Descriptor:	TR109 heavy chain, TR109 light chain, TR92 heavy chain, ...
Authors:	Akiba, H, Fujita, J, Ise, T, Nishiyama, K, Miyata, T, Kato, T, Namba, K, Ohno, H, Kamada, H, Nagata, S, Tsumoto, K.
Deposit date:	2022-11-29
Release date:	2023-10-04
Method:	ELECTRON MICROSCOPY (3.63 Å)
Cite:	Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection. Commun Biol, 6, 2023

TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity
Descriptor:	Tumor necrosis factor
Authors:	Mukai, Y, Yamagata, Y, Tsutsumi, Y.
Deposit date:	2007-01-09
Release date:	2007-11-13
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist J.Biol.Chem., 283, 2008

TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity; R1antTNF-T8
Descriptor:	Tumor necrosis factor
Authors:	Mukai, Y, Nakamura, T, Yamagata, Y, Tsutsumi, Y.
Deposit date:	2008-07-29
Release date:	2009-03-24
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (2.83 Å)
Cite:	Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists J.Biochem., 146, 2009

TNFR1 selectve TNF mutant; R1-6
Descriptor:	GLYCEROL, Tumor necrosis factor
Authors:	Mukai, Y, Yamagata, Y, Tsutsumi, Y.
Deposit date:	2008-03-05
Release date:	2009-01-20
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Structure-Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant J.Mol.Biol., 385, 2009