1T7K
 
 | | Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea | | Descriptor: | 3-({5-BENZYL-6-HYDROXY-2,4-BIS-(4-HYDROXY-BENZYL)-3-OXO-[1,2,4]-TRIAZEPANE-1-SULFONYL)-BENZONITRILE, Pol polyprotein [Contains: Protease (Retropepsin)] | | Authors: | Huang, P.P, Randolph, J.T, Klein, L.L, Vasavanonda, S, Dekhtyar, T, Stoll, V.S, Kempf, D.J. | | Deposit date: | 2004-05-10 | | Release date: | 2004-10-05 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Synthesis and Antiviral Activity of P1' Arylsulfonamide Azacyclic Urea HIV Protease Inhibitors
Bioorg.Med.Chem.Lett., 14, 2004
|
|
8JR8
 | | MapSPARTA dimer bound with guide-target | | Descriptor: | DNA (25-MER), Piwi domain-containing protein, RNA (5'-R(P*UP*GP*AP*CP*GP*GP*CP*UP*CP*UP*AP*AP*UP*CP*UP*AP*UP*UP*AP*GP*U)-3'), ... | | Authors: | Huang, P.P, Li, Z.X, Guo, L.J, Xiao, Y.B, Chen, M.R. | | Deposit date: | 2023-06-16 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Cryo-EM Structure of MapSPARTA
To Be Published
|
|
8WP2
 | | MapSPARTA tetramer bound with guide-target | | Descriptor: | DNA (25-MER), Piwi domain-containing protein, RNA (5'-R(P*UP*GP*AP*CP*GP*GP*CP*UP*CP*UP*AP*AP*UP*CP*UP*AP*UP*UP*AP*GP*U)-3'), ... | | Authors: | Huang, P.P, Li, Z.X, Guo, L.J, Xiao, Y.B, Chen, M.R. | | Deposit date: | 2023-10-08 | | Release date: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM Structure of MapSPARTA
To Be Published
|
|
9IW3
 | | Cryo-EM structure of Lactobacillus casei DdmE bound with guide and target | | Descriptor: | DNA (25-MER), DNA (5'-D(P*CP*TP*TP*GP*AP*TP*AP*CP*GP*AP*C)-3'), DNA (5'-D(P*TP*GP*AP*CP*GP*GP*CP*TP*CP*TP*AP*AP*TP*CP*T)-3'), ... | | Authors: | Huang, P.P, Chen, M.R, Xiao, Y.B. | | Deposit date: | 2024-07-25 | | Release date: | 2025-01-01 | | Method: | ELECTRON MICROSCOPY (3.58 Å) | | Cite: | The mechanism of bacterial defense system DdmDE from Lactobacillus casei.
Cell Res., 34, 2024
|
|
9IX4
 | | Cryo-EM structure of Lactobacillus casei DdmD dimer bound with DNA | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*AP*TP*GP*AP*GP*TP*AP*TP*AP*TP*CP*C)-3'), ... | | Authors: | Huang, P.P, Chen, M.R, Xiao, Y.B. | | Deposit date: | 2024-07-26 | | Release date: | 2025-01-01 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | The mechanism of bacterial defense system DdmDE from Lactobacillus casei.
Cell Res., 34, 2024
|
|
9IXM
 | | Cryo-EM structure of Lactobacillus casei DdmDE bound with DNA | | Descriptor: | DNA (30-MER), DNA (5'-D(P*TP*GP*AP*CP*GP*GP*CP*TP*CP*TP*AP*AP*TP*CP*T)-3'), DdmD, ... | | Authors: | Huang, P.P, Chen, M.R, Xiao, Y.B. | | Deposit date: | 2024-07-29 | | Release date: | 2025-01-01 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | The mechanism of bacterial defense system DdmDE from Lactobacillus casei.
Cell Res., 34, 2024
|
|
8JAY
 | | CrtSPARTA Octamer bound with guide-target | | Descriptor: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | | Authors: | Guo, L.J, Huang, P.P, Li, Z.X, Xiao, Y.B, Chen, M.R. | | Deposit date: | 2023-05-07 | | Release date: | 2024-03-20 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.
Nat.Chem.Biol., 20, 2024
|
|
8J9G
 | | CrtSPARTA hetero-dimer bound with guide-target, state 1 | | Descriptor: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | | Authors: | Li, Z.X, Guo, L.J, Huang, P.P, Xiao, Y.B, Chen, M.R. | | Deposit date: | 2023-05-03 | | Release date: | 2024-03-06 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.
Nat.Chem.Biol., 20, 2024
|
|
8J8H
 | | SPARTA monomer bound with guide-target, state 2 | | Descriptor: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | | Authors: | Li, Z.X, Guo, L.J, Huang, P.P, Xiao, Y.B, Chen, M.R. | | Deposit date: | 2023-05-01 | | Release date: | 2024-03-06 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.
Nat.Chem.Biol., 20, 2024
|
|
8J9P
 | | SPARTA dimer bound with guide-target | | Descriptor: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | | Authors: | Li, Z.X, Guo, L.J, Huang, P.P, Xiao, Y.B, Chen, M.R. | | Deposit date: | 2023-05-04 | | Release date: | 2024-03-06 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.
Nat.Chem.Biol., 20, 2024
|
|
8J84
 | | Short ago complexed with TIR-APAZ | | Descriptor: | Piwi domain-containing protein, TIR domain-containing protein | | Authors: | Guo, L.J, Huang, P.P, Li, Z.X, Xiao, Y.B, Chen, M.R. | | Deposit date: | 2023-04-30 | | Release date: | 2024-03-13 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.
Nat.Chem.Biol., 20, 2024
|
|
