1T7K

Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea

Summary for 1T7K

Entry DOI	10.2210/pdb1t7k/pdb
Related	1MUI
Descriptor	Pol polyprotein [Contains: Protease (Retropepsin)], 3-({5-BENZYL-6-HYDROXY-2,4-BIS-(4-HYDROXY-BENZYL)-3-OXO-[1,2,4]-TRIAZEPANE-1-SULFONYL)-BENZONITRILE (3 entities in total)
Functional Keywords	hiv protease, arylsulfonamide azacyclic urea, hydrolase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22206.18
Authors	Huang, P.P.,Randolph, J.T.,Klein, L.L.,Vasavanonda, S.,Dekhtyar, T.,Stoll, V.S.,Kempf, D.J. (deposition date: 2004-05-10, release date: 2004-10-05, Last modification date: 2024-02-14)
Primary citation	Huang, P.P.,Randolph, J.T.,Klein, L.L.,Vasavanonda, S.,Dekhtyar, T.,Stoll, V.S.,Kempf, D.J. Synthesis and Antiviral Activity of P1' Arylsulfonamide Azacyclic Urea HIV Protease Inhibitors Bioorg.Med.Chem.Lett., 14:4075-4078, 2004 Cited by PubMed: 15225729 DOI: 10.1016/j.bmcl.2004.05.036 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation