1T7K
Crystal Structure of HIV Protease complexed with Arylsulfonamide azacyclic urea
Summary for 1T7K
Entry DOI | 10.2210/pdb1t7k/pdb |
Related | 1MUI |
Descriptor | Pol polyprotein [Contains: Protease (Retropepsin)], 3-({5-BENZYL-6-HYDROXY-2,4-BIS-(4-HYDROXY-BENZYL)-3-OXO-[1,2,4]-TRIAZEPANE-1-SULFONYL)-BENZONITRILE (3 entities in total) |
Functional Keywords | hiv protease, arylsulfonamide azacyclic urea, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22206.18 |
Authors | Huang, P.P.,Randolph, J.T.,Klein, L.L.,Vasavanonda, S.,Dekhtyar, T.,Stoll, V.S.,Kempf, D.J. (deposition date: 2004-05-10, release date: 2004-10-05, Last modification date: 2024-02-14) |
Primary citation | Huang, P.P.,Randolph, J.T.,Klein, L.L.,Vasavanonda, S.,Dekhtyar, T.,Stoll, V.S.,Kempf, D.J. Synthesis and Antiviral Activity of P1' Arylsulfonamide Azacyclic Urea HIV Protease Inhibitors Bioorg.Med.Chem.Lett., 14:4075-4078, 2004 Cited by PubMed: 15225729DOI: 10.1016/j.bmcl.2004.05.036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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