4KZE
 
 | | Crystal structure of an RNA aptamer in complex with Fab | | Descriptor: | BL3-6 Fab antibody, heavy chain, light chain, ... | | Authors: | Huang, H, Suslov, N.B, Li, N, Koldobskaya, Y, Rice, P.A, Piccirilli, J.A. | | Deposit date: | 2013-05-29 | | Release date: | 2014-06-18 | | Last modified: | 2014-07-30 | | Method: | X-RAY DIFFRACTION (2.404 Å) | | Cite: | A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore.
Nat.Chem.Biol., 10, 2014
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4O1O
 | | Crystal Structure of RNase L in complex with 2-5A | | Descriptor: | Ribonuclease L, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate | | Authors: | Huang, H, Zeqiraj, E, Ceccarelli, D.F, Sicheri, F. | | Deposit date: | 2013-12-16 | | Release date: | 2014-02-05 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.27 Å) | | Cite: | Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Mol.Cell, 53, 2014
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4O1P
 | | Crystal Structure of RNase L in complex with 2-5A and AMP-PNP | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribonuclease L, ... | | Authors: | Huang, H, Zeqiraj, E, Ceccarelli, D.F, Sicheri, F. | | Deposit date: | 2013-12-16 | | Release date: | 2014-02-05 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Mol.Cell, 53, 2014
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2LBI
 | | N2-dG:N2-dG interstrand cross-link induced by trans-4-hydroxynonenal | | Descriptor: | (4S)-nonane-1,4-diol, DNA (5'-D(*GP*CP*TP*AP*GP*CP*GP*AP*GP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*CP*TP*CP*GP*CP*TP*AP*GP*C)-3') | | Authors: | Huang, H, Kozekov, I.D, Wang, H, Kozekova, A, Rizzo, C.J, Stone, M.P. | | Deposit date: | 2011-03-31 | | Release date: | 2012-04-04 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Formation of a N2-dG:N2-dG carbinolamine DNA cross-link by the trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N2-dG adduct.
J.Am.Chem.Soc., 133, 2011
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5BNX
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5BO0
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5BNV
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2KEB
 | | NMR solution structure of the N-terminal domain of the DNA polymerase alpha p68 subunit | | Descriptor: | DNA polymerase subunit alpha B | | Authors: | Huang, H, Weiner, B.E, Zhang, H, Fuller, B.E, Gao, Y, Wile, B.M, Chazin, W.J, Fanning, E. | | Deposit date: | 2009-01-28 | | Release date: | 2010-02-02 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Structure of a DNA polymerase alpha-primase domain that docks on the SV40 helicase and activates the viral primosome.
J.Biol.Chem., 285, 2010
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2KSZ
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2LG3
 | | Structure of the duplex containing HNE derived (6S,8R,11S) gamma-HO-PdG when placed opposite dT | | Descriptor: | (4S)-nonane-1,4-diol, DNA (5'-D(*GP*CP*TP*AP*GP*CP*GP*AP*GP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*CP*TP*TP*GP*CP*TP*AP*GP*C)-3') | | Authors: | Huang, H, Wang, H, Kozekova, A, Lloyd, R.S, Rizzo, C.J, Stone, M.P. | | Deposit date: | 2011-07-19 | | Release date: | 2012-08-01 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Ring-chain tautomerization of trans-4-hydroxynonenal derived (6S,8R,11S) gamma-hydroxy-1,N2-propano-deoxyguanosine adduct when placed opposite 2'-deoxythymidine in duplex
To be Published
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2L4I
 | | The Solution Structure of Magnesium bound CIB1 | | Descriptor: | Calcium and integrin-binding protein 1, MAGNESIUM ION | | Authors: | Huang, H, Vogel, H.J. | | Deposit date: | 2010-10-06 | | Release date: | 2011-03-09 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution Structures of Ca2+-CIB1 and Mg2+-CIB1 and Their Interactions with the Platelet Integrin {alpha}IIb Cytoplasmic Domain.
J.Biol.Chem., 286, 2011
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2L4H
 | | The Solution Structure of Calcium Bound CIB1 | | Descriptor: | CALCIUM ION, Calcium and integrin-binding protein 1 | | Authors: | Huang, H, Vogel, H.J. | | Deposit date: | 2010-10-06 | | Release date: | 2011-03-09 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution Structures of Ca2+-CIB1 and Mg2+-CIB1 and Their Interactions with the Platelet Integrin {alpha}IIb Cytoplasmic Domain.
J.Biol.Chem., 286, 2011
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2LFY
 | | Structure of the duplex when (5'S)-8,5'-cyclo-2'-deoxyguanosine is placed opposite dA | | Descriptor: | DNA (5'-D(*AP*CP*AP*AP*AP*CP*AP*AP*GP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*CP*(2LF)P*TP*GP*TP*TP*TP*GP*T)-3') | | Authors: | Huang, H, Das, R.S, Basu, A, Stone, M.P. | | Deposit date: | 2011-07-18 | | Release date: | 2012-06-27 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structures of (5'S)-8,5'-Cyclo-2'-deoxyguanosine Mismatched with dA or dT.
Chem.Res.Toxicol., 25, 2012
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2G4A
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2JAZ
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2JB0
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2JBG
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2KNL
 | | Structure of the trimethylene N2-dG:N2-dG interstrand cross-link in the 5'-GpC-3' sequence context | | Descriptor: | DNA (5'-D(*TP*CP*CP*GP*CP*GP*GP*A)-3'), PROPANE | | Authors: | Huang, H, Dooley, P.A, Harris, C.M, Harris, T.M, Stone, M.P. | | Deposit date: | 2009-08-26 | | Release date: | 2009-09-29 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Differential base stacking interactions induced by trimethylene interstrand DNA cross-links in the 5'-CpG-3' and 5'-GpC-3' sequence contexts.
Chem.Res.Toxicol., 22, 2009
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2KNK
 | | Structure of the trimethylene N2-dG:N2-dG interstrand cross-link in 5'-CpG-3' sequence context | | Descriptor: | DNA (5'-D(*AP*GP*GP*CP*GP*CP*CP*T)-3'), PROPANE | | Authors: | Huang, H, Dooley, P.A, Harris, C.M, Harris, T.M, Stone, M.P. | | Deposit date: | 2009-08-26 | | Release date: | 2009-09-29 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Differential base stacking interactions induced by trimethylene interstrand DNA cross-links in the 5'-CpG-3' and 5'-GpC-3' sequence contexts.
Chem.Res.Toxicol., 22, 2009
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2KV6
 | | Tetrapeptide KWKK conjugated to oligonucleotide duplex by a trimethylene tether | | Descriptor: | 5'-D(*GP*CP*TP*AP*GP*CP*GP*AP*GP*TP*CP*C)-3', 5'-D(*GP*GP*AP*CP*TP*CP*GP*CP*TP*AP*GP*C)-3', KWKK Tetrapeptide | | Authors: | Huang, H, Kozekov, I.D, Kozekova, A, Rizzo, C.J, McCullough, A, LLoyd, R.S, Stone, M.P. | | Deposit date: | 2010-03-08 | | Release date: | 2010-07-21 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Minor Groove Orientation of the KWKK Peptide Tethered via the N-Terminal Amine to the Acrolein-Derived 1,N(2)-gamma-Hydroxypropanodeoxyguanosine Lesion with a Trimethylene Linkage .
Biochemistry, 49, 2010
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2LFA
 | | Oligonucleotide duplex contaning (5'S)-8,5'-cyclo-2'-deoxyguansine | | Descriptor: | DNA (5'-D(*AP*CP*AP*AP*AP*CP*AP*CP*GP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*CP*(2LF)P*TP*GP*TP*TP*TP*GP*T)-3') | | Authors: | Huang, H, Das, R.S, Basu, A, Stone, M.P. | | Deposit date: | 2011-06-29 | | Release date: | 2012-01-04 | | Method: | SOLUTION NMR | | Cite: | Structure of (5'S)-8,5'-Cyclo-2'-deoxyguanosine in DNA.
J.Am.Chem.Soc., 133, 2011
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2LM5
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2LFX
 | | Structure of the duplex when (5'S)-8,5'-cyclo-2'-deoxyguanosine is placed opposite dT | | Descriptor: | DNA (5'-D(*AP*CP*AP*AP*AP*CP*AP*TP*GP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*CP*(2LF)P*TP*GP*TP*TP*TP*GP*T)-3') | | Authors: | Huang, H, Das, R.S, Basu, A, Stone, M.P. | | Deposit date: | 2011-07-18 | | Release date: | 2012-06-27 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structures of (5'S)-8,5'-Cyclo-2'-deoxyguanosine Mismatched with dA or dT.
Chem.Res.Toxicol., 25, 2012
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2LG0
 | | structure of the duplex containing (5'S)-8,5'-cyclo-2'-deoxyadenosine | | Descriptor: | DNA (5'-D(*AP*CP*AP*AP*AP*CP*AP*TP*GP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*CP*(02I)P*TP*GP*TP*TP*TP*GP*T)-3') | | Authors: | Huang, H, Das, R.S, Basu, A, Stone, M.P. | | Deposit date: | 2011-07-18 | | Release date: | 2012-06-27 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structure of (5'S)-8,5'-cyclo-2'-deoxyguanosine in DNA.
J.Am.Chem.Soc., 133, 2011
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5Y6O
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