2LBI

N2-dG:N2-dG interstrand cross-link induced by trans-4-hydroxynonenal

Summary for 2LBI

• Entry DOI: 10.2210/pdb2lbi/pdb
• NMR Information: BMRB: 17562
• Descriptor: DNA (5'-D(*GP*CP*TP*AP*GP*CP*GP*AP*GP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*CP*TP*CP*GP*CP*TP*AP*GP*C)-3'), (4S)-nonane-1,4-diol (3 entities in total)
• Functional Keywords: trans-4-hydroxynonenal, interstrand cross-link, dna
• Total number of polymer chains: 2
• Total formula weight: 7487.04

Authors

Huang, H.,Kozekov, I.D.,Wang, H.,Kozekova, A.,Rizzo, C.J.,Stone, M.P. (deposition date: 2011-03-31, release date: 2012-04-04, Last modification date: 2023-06-14)

• Primary citation: Huang, H.,Wang, H.,Kozekova, A.,Rizzo, C.J.,Stone, M.P.; Formation of a N2-dG:N2-dG carbinolamine DNA cross-link by the trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N2-dG adduct.; J.Am.Chem.Soc., 133:16101-16110, 2011; PubMed: 21916419; DOI: 10.1021/ja205145q

Experimental method

SOLUTION NMR