5I82
 
 | | First Crystal Structure of E.coli Based Recombinant Diphtheria Toxin Mutant CRM197 | | 分子名称: | Diphtheria toxin, GLYCEROL, SULFATE ION | | 著者 | Minasov, G, Shuvalova, L, Mishra, R.P.N, Goel, A, Dubrovska, I, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2016-02-18 | | 公開日 | 2016-03-02 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural and immunological characterization of E. coli derived recombinant CRM 197 protein used as carrier in conjugate vaccines.
Biosci.Rep., 38, 2018
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5M11
 | | Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis. | | 分子名称: | CACODYLATE ION, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Lasica, A.M, Goulas, T, Mizgalska, D, Zhou, X, Ksiazek, M, Madej, M, Guo, Y, Guevara, T, Nowak, M, Potempa, B, Goel, A, Sztukowska, M, Prabhakar, A.T, Bzowska, M, Widziolek, M, Thogersen, I.B, Enghild, J.J, Simonian, M, Kulczyk, A.W, Nguyen, K.-A, Potempa, J, Gomis-Ruth, F.X. | | 登録日 | 2016-10-07 | | 公開日 | 2016-11-09 | | 最終更新日 | 2022-03-30 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.
Sci Rep, 6, 2016
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4AAI
 | | THERMOSTABLE PROTEIN FROM HYPERTHERMOPHILIC VIRUS SSV-RH | | 分子名称: | ORF E73 | | 著者 | Schlenker, C, Goel, A, Tripet, B.P, Menon, S, Lawrence, C.M, Copie, V. | | 登録日 | 2011-12-02 | | 公開日 | 2012-01-11 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Studies of E73 from a Hyperthermophilic Archaeal Virus Identify the "Rh3" Domain, an Elaborated Ribbon-Helix- Helix Motif Involved in DNA Recognition.
Biochemistry, 51, 2012
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4ONF
 | | Fab fragment of 3D6 in complex with amyloid beta 1-7 | | 分子名称: | 3D6 FAB ANTIBODY HEAVY CHAIN, 3D6 FAB ANTIBODY LIGHT CHAIN, Amyloid beta A4 protein | | 著者 | Feinberg, H, Saldanha, J.W, Diep, L, Goel, A, Widom, A, Veldman, G.M, Weis, W.I, Schenk, D, Basi, G.S. | | 登録日 | 2014-01-28 | | 公開日 | 2014-06-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab.
Alzheimers Res Ther, 6, 2014
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4ONG
 | | Fab fragment of 3D6 in complex with amyloid beta 1-40 | | 分子名称: | 3D6 FAB ANTIBODY HEAVY CHAIN, 3D6 FAB ANTIBODY LIGHT CHAIN, Amyloid beta A4 protein, ... | | 著者 | Feinberg, H, Saldanha, J.W, Diep, L, Goel, A, Widom, A, Veldman, G.M, Weis, W.I, Schenk, D, Basi, G.S. | | 登録日 | 2014-01-28 | | 公開日 | 2014-06-11 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab.
Alzheimers Res Ther, 6, 2014
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3UGC
 | | Structural basis of Jak2 inhibition by the type II inhibtor NVP-BBT594 | | 分子名称: | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1H-indole-1-carboxamide, MALONATE ION, Tyrosine-protein kinase JAK2 | | 著者 | Scheufler, C, Tavares, G.A, Manley, P.W, Pissot-Soldermann, C, Kroemer, M. | | 登録日 | 2011-11-02 | | 公開日 | 2012-05-16 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent.
Cancer Discov, 2, 2012
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3IFN
 | | X-ray structure of amyloid beta peptide:antibody (Abeta1-40:12A11) complex | | 分子名称: | 12A11 FAB antibody heavy chain, 12A11 FAB antibody light chain, Amyloid beta A4 protein | | 著者 | Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D. | | 登録日 | 2009-07-24 | | 公開日 | 2009-11-17 | | 最終更新日 | 2013-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J.Biol.Chem., 285, 2010
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3IFO
 | | X-ray structure of amyloid beta peptide:antibody (Abeta1-7:10D5) complex | | 分子名称: | 10D5 FAB antibody heavy chain, 10D5 FAB antibody light chain, Amyloid beta A4 protein | | 著者 | Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D. | | 登録日 | 2009-07-24 | | 公開日 | 2009-11-17 | | 最終更新日 | 2013-09-25 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J.Biol.Chem., 285, 2010
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3IFP
 | | X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12B4) complex | | 分子名称: | 12B4 FAB antibody heavy chain, 12B4 FAB antibody light chain, Amyloid beta A4 protein | | 著者 | Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D. | | 登録日 | 2009-07-24 | | 公開日 | 2009-11-17 | | 最終更新日 | 2013-09-25 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J.Biol.Chem., 285, 2010
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3IFL
 | | X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12A11) complex | | 分子名称: | 12A11 FAB antibody heavy chain, 12A11 FAB antibody light chain, Amyloid beta A4 protein | | 著者 | Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D. | | 登録日 | 2009-07-24 | | 公開日 | 2009-11-17 | | 最終更新日 | 2013-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J.Biol.Chem., 285, 2010
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5X57
 | | Structure of GAR domain of ACF7 | | 分子名称: | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5, NICKEL (II) ION | | 著者 | Yang, F, Wang, T, Zhang, Y, Wu, X.Y. | | 登録日 | 2017-02-15 | | 公開日 | 2017-07-05 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics.
Nat Commun, 8, 2017
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5ZTN
 | | The crystal structure of human DYRK2 in complex with Curcumin | | 分子名称: | (1Z,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one, Dual specificity tyrosine-phosphorylation-regulated kinase 2 | | 著者 | Ji, C.G, Xiao, J.Y. | | 登録日 | 2018-05-04 | | 公開日 | 2018-07-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.496 Å) | | 主引用文献 | Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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