1JEG
 
 | | Solution structure of the SH3 domain from C-terminal Src Kinase complexed with a peptide from the tyrosine phosphatase PEP | | 分子名称: | HEMATOPOIETIC CELL PROTEIN-TYROSINE PHOSPHATASE 70Z-PEP, TYROSINE-PROTEIN KINASE CSK | | 著者 | Ghose, R, Shekhtman, A, Goger, M.J, Ji, H, Cowburn, D. | | 登録日 | 2001-06-17 | | 公開日 | 2001-10-31 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A novel, specific interaction involving the Csk SH3 domain and its natural ligand.
Nat.Struct.Biol., 8, 2001
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5KS5
 | | Structure of the C-terminal Helical Repeat Domain of Elongation Factor 2 Kinase | | 分子名称: | Eukaryotic elongation factor 2 kinase | | 著者 | Piserchio, A, Will, N, Snyder, I, Ferguson, S.B, Giles, D.H, Dalby, K.N, Ghose, R. | | 登録日 | 2016-07-07 | | 公開日 | 2016-09-14 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the C-Terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase.
Biochemistry, 55, 2016
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7SHQ
 | | Structure of a functional construct of eukaryotic elongation factor 2 kinase in complex with calmodulin. | | 分子名称: | CALCIUM ION, Calmodulin-1, Eukaryotic elongation factor 2 kinase,Eukaryotic elongation factor 2 kinase, ... | | 著者 | Piserchio, A, Isiorho, E.A, Jeruzalmi, D, Dalby, K.N, Ghose, R. | | 登録日 | 2021-10-11 | | 公開日 | 2022-04-06 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Structural basis for the calmodulin-mediated activation of eukaryotic elongation factor 2 kinase.
Sci Adv, 8, 2022
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5J8H
 | | Structure of calmodulin in a complex with a peptide derived from a calmodulin-dependent kinase | | 分子名称: | CALCIUM ION, Calmodulin, Eukaryotic elongation factor 2 kinase | | 著者 | Alphonse, S, Lee, K, Piserchio, A, Tavares, C.D.J, Giles, D.H, Wellmann, R.M, Dalby, K.N, Ghose, R. | | 登録日 | 2016-04-07 | | 公開日 | 2016-09-07 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin.
Structure, 24, 2016
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8GM5
 | | Functional construct of the Eukaryotic elongation factor 2 kinase bound to Calmodulin, ADP and to the A-484954 inhibitor and showing two conformations for the 498-520 loop | | 分子名称: | 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | | 著者 | Piserchio, A, Isiorho, E.A, Dalby, K.N, Ghose, R. | | 登録日 | 2023-03-24 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor.
J.Biol.Chem., 299, 2023
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8GM4
 | | Functional construct of the Eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor | | 分子名称: | 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | | 著者 | Piserchio, A, Isiorho, E.A, Dalby, K.N, Ghose, R. | | 登録日 | 2023-03-24 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor.
J.Biol.Chem., 299, 2023
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8FNY
 | | Nucleotide-bound structure of a functional construct of eukaryotic elongation factor 2 kinase. | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | | 著者 | Piserchio, A, Isiorho, E.A, Dalby, K.N, Ghose, R. | | 登録日 | 2022-12-28 | | 公開日 | 2023-05-03 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8FO6
 | | Nucleotide-free structure of a functional construct of eukaryotic elongation factor 2 kinase. | | 分子名称: | CALCIUM ION, Calmodulin-1, Eukaryotic elongation factor 2 kinase, ... | | 著者 | Piserchio, A, Isiorho, E.A, Dalby, K.N, Ghose, R. | | 登録日 | 2022-12-29 | | 公開日 | 2023-05-03 | | 実験手法 | X-RAY DIFFRACTION (2.553 Å) | | 主引用文献 | ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin.
Proc.Natl.Acad.Sci.USA, 120, 2023
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6NBS
 | | WT ERK2 with compound 2507-8 | | 分子名称: | (5S)-5-benzyl-4,5-dihydro-1H-imidazol-2-amine, GLYCEROL, Mitogen-activated protein kinase 1, ... | | 著者 | Sammons, R.M, Perry, N.A, Cho, E.J, Kaoud, T.S, Zamora-Olivares, D.P, Piserchio, A, Houghten, R.A, Giulianotti, M, Li, Y, Debevec, G, Gurevich, V.V, Ghose, R, Iverson, T.M, Dalby, K.N. | | 登録日 | 2018-12-10 | | 公開日 | 2019-07-31 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation.
Acs Chem.Biol., 14, 2019
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6NX4
 | | Structure of the C-terminal Helical Repeat Domain of Eukaryotic Elongation Factor 2 Kinase (eEF-2K) | | 分子名称: | Eukaryotic elongation factor 2 kinase | | 著者 | Piserchio, A, Will, N, Giles, D.H, Hajredini, F, Dalby, K.N, Ghose, R. | | 登録日 | 2019-02-08 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of the Carboxy-Terminal Tandem Repeat Domain of Eukaryotic Elongation Factor 2 Kinase and Its Role in Substrate Recognition.
J.Mol.Biol., 431, 2019
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7KW9
 | | NMR Structure of a tRNA 2'-phosphotransferase from Runella slithyformis in complex with NAD+ | | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, tRNA 2'-phosphotransferase | | 著者 | Alphonse, S, Dantuluri, S, Banerjee, A, Shuman, S, Ghose, R. | | 登録日 | 2020-11-30 | | 公開日 | 2021-10-13 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR solution structures of Runella slithyformis RNA 2'-phosphotransferase Tpt1 provide insights into NAD+ binding and specificity.
Nucleic Acids Res., 49, 2021
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7KW8
 | | NMR Structure of a tRNA 2'-phosphotransferase from Runella slithyformis | | 分子名称: | tRNA 2'-phosphotransferase | | 著者 | Alphonse, S, Dantuluri, S, Banerjee, A, Shuman, S, Ghose, R. | | 登録日 | 2020-11-30 | | 公開日 | 2021-10-13 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR solution structures of Runella slithyformis RNA 2'-phosphotransferase Tpt1 provide insights into NAD+ binding and specificity.
Nucleic Acids Res., 49, 2021
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2HM2
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4IEG
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4GZK
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2GQC
 | | Solution structure of the N-terminal domain of Rhomboid Intramembrane Protease from P. aeruginosa | | 分子名称: | Rhomboid Intramembrane Protease | | 著者 | Dutta, K, Del Rio, A, Chavez, J, Ubarretxena-Belandia, I, Ghose, R. | | 登録日 | 2006-04-20 | | 公開日 | 2007-03-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure and dynamics of the N-terminal cytosolic domain of rhomboid intramembrane protease from Pseudomonas aeruginosa: insights into a functional role in intramembrane proteolysis.
J.Mol.Biol., 365, 2007
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2LJ6
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2Q82
 | | Crystal structure of core protein P7 from Pseudomonas phage phi12. Northeast Structural Genomics Target OC1 | | 分子名称: | Core protein P7 | | 著者 | Benach, J, Eryilmaz, E, Su, M, Seetharaman, J, Wei, H, Gottlieb, P, Hunt, J.F, Ghose, R, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2007-06-08 | | 公開日 | 2007-08-07 | | 最終更新日 | 2017-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Structure and dynamics of the P7 protein from the bacteriophage phi 12.
J.Mol.Biol., 382, 2008
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1FH1
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