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VLA1 RdeltaH I-domain complexed with a quadruple mutant of the AQC2 Fab
Descriptor:	Antibody AQC2 Fab, Integrin alpha-1, MAGNESIUM ION
Authors:	Clark, L.A, Boriack-Sjodin, P.A, Eldredge, J, Fitch, C, Friedman, B, Hanf, K.J, Jarpe, M, Liparoto, S.F, Li, Y, Lugovskoy, A.
Deposit date:	2005-09-19
Release date:	2006-04-18
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design Protein Sci., 15, 2006

Crystal structure of TGFbRI complexed with a 2-aminoimidazole inhibitor
Descriptor:	N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide, PHOSPHATE ION, TGF-beta receptor type-1
Authors:	Boriack-Sjodin, P.A, Fitch, C.
Deposit date:	2008-11-16
Release date:	2009-01-27
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (3.35 Å)
Cite:	2-Aminoimidazoles inhibitors of TGF-beta receptor 1. Bioorg.Med.Chem.Lett., 19, 2009

Crystal structure of LAC031, an engineered anti-VLA1 Fab
Descriptor:	FAB FRAGMENT, HEAVY CHAIN, LIGHT CHAIN
Authors:	Boriack-Sjodin, P.A, Clark, L.A.
Deposit date:	2008-09-29
Release date:	2009-01-20
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	An antibody loop replacement design feasibility study and a loop-swapped dimer structure. Protein Eng.Des.Sel., 22, 2009