3EOT

Crystal structure of LAC031, an engineered anti-VLA1 Fab

Summary for 3EOT

• Entry DOI: 10.2210/pdb3eot/pdb
• Related: 1MHP
• Descriptor: FAB FRAGMENT, HEAVY CHAIN, FAB FRAGMENT, LIGHT CHAIN (3 entities in total)
• Functional Keywords: antibody, fab, vla-1, domain swap, proten engineering, immune system
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 2
• Total formula weight: 47738.90

Authors

Boriack-Sjodin, P.A.,Clark, L.A. (deposition date: 2008-09-29, release date: 2009-01-20, Last modification date: 2017-10-25)

• Primary citation: Clark, L.A.,Boriack-Sjodin, P.A.,Day, E.,Eldredge, J.,Fitch, C.,Jarpe, M.,Miller, S.,Li, Y.,Simon, K.,van Vlijmen, H.W.; An antibody loop replacement design feasibility study and a loop-swapped dimer structure.; Protein Eng.Des.Sel., 22:93-101, 2009; PubMed: 19074157; DOI: 10.1093/protein/gzn072

Experimental method

X-RAY DIFFRACTION (1.9 Å)