1QPU
| SOLUTION STRUCTURE OF OXIDIZED ESCHERICHIA COLI CYTOCHROME B562 | Descriptor: | CYTOCHROME B562, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Arnesano, F, Banci, L, Bertini, I, Faraone-Mennella, J, Rosato, A, Barker, P.D, Fersht, A.R. | Deposit date: | 1999-05-30 | Release date: | 1999-06-02 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The solution structure of oxidized Escherichia coli cytochrome b562. Biochemistry, 38, 1999
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2WXC
| The folding mechanism of BBL: Plasticity of transition-state structure observed within an ultrafast folding protein family. | Descriptor: | DIHYDROLIPOYLTRANSSUCCINASE | Authors: | Neuweiler, H, Sharpe, T.D, Rutherford, T.J, Johnson, C.M, Allen, M.D, Ferguson, N, Fersht, A.R. | Deposit date: | 2009-11-06 | Release date: | 2009-11-17 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Folding Mechanism of Bbl: Plasticity of Transition-State Structure Observed within an Ultrafast Folding Protein Family. J.Mol.Biol., 390, 2009
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2XWR
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2KZG
| A Transient and Low Populated Protein Folding Intermediate at Atomic Resolution | Descriptor: | Pre-mRNA-processing factor 40 homolog A | Authors: | Korzhnev, D.M, Religa, T.L, Banachewicz, W, Fersht, A.R, Kay, L.E. | Deposit date: | 2010-06-17 | Release date: | 2010-09-29 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | A transient and low-populated protein-folding intermediate at atomic resolution. Science, 329, 2010
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2YBG
| Structure of Lys120-acetylated p53 core domain | Descriptor: | CELLULAR TUMOR ANTIGEN P53, ZINC ION | Authors: | Arbely, E, Allen, M.D, Joerger, A.C, Fersht, A.R. | Deposit date: | 2011-03-08 | Release date: | 2011-05-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Acetylation of Lysine 120 of P53 Endows DNA- Binding Specificity at Effective Physiological Salt Concentration. Proc.Natl.Acad.Sci.USA, 108, 2011
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5LAP
| p53 cancer mutant Y220C with Cys182 alkylation | Descriptor: | 5-chloranylpyrimidine-4-carboxylic acid, Cellular tumor antigen p53, ZINC ION | Authors: | Joerger, A.C, Bauer, M.R, Fersht, A.R. | Deposit date: | 2016-06-14 | Release date: | 2016-08-10 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | 2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells. Proc.Natl.Acad.Sci.USA, 113, 2016
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1UOL
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2BIO
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2BIQ
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2BIP
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2BIN
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2BIM
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1JON
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1HL2
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1KID
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1KCQ
| Human Gelsolin Domain 2 with a Cd2+ bound | Descriptor: | CADMIUM ION, GELSOLIN | Authors: | Kazmirski, S.L, Isaacson, R.L, An, C, Buckle, A, Johnson, C.M, Daggett, V, Fersht, A.R. | Deposit date: | 2001-11-09 | Release date: | 2002-01-04 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type. Nat.Struct.Biol., 9, 2002
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5AOJ
| Structure of the p53 cancer mutant Y220C in complex with 2-hydroxy-3, 5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid | Descriptor: | 2-hydroxy-3,5-diiodo-4-(1H-pyrrol-1-yl)benzoic acid, CELLULAR TUMOR ANTIGEN P53, DI(HYDROXYETHYL)ETHER, ... | Authors: | Joerger, A.C, Baud, M.G, Bauer, M.R, Fersht, A.R. | Deposit date: | 2015-09-10 | Release date: | 2015-12-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015
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1SS1
| STAPHYLOCOCCAL PROTEIN A, B-DOMAIN, Y15W MUTANT, NMR, 25 STRUCTURES | Descriptor: | Immunoglobulin G binding protein A | Authors: | Sato, S, Religa, T.L, Daggett, V, Fersht, A.R. | Deposit date: | 2004-03-23 | Release date: | 2004-04-06 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | From The Cover: Testing protein-folding simulations by experiment: B domain of protein A. Proc.Natl.Acad.Sci.USA, 101, 2004
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2C6A
| Solution structure of the C4 zinc-finger domain of HDM2 | Descriptor: | UBIQUITIN-PROTEIN LIGASE E3 MDM2, ZINC ION | Authors: | Yu, G.W, Allen, M.D, Andreeva, A, Fersht, A.R, Bycroft, M. | Deposit date: | 2005-11-08 | Release date: | 2006-01-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution Structure of the C4 Zinc Finger Domain of Hdm2. Protein Sci., 15, 2006
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2C6B
| Solution structure of the C4 zinc-finger domain of HDM2 | Descriptor: | UBIQUITIN-PROTEIN LIGASE E3 MDM2, ZINC ION | Authors: | Yu, G.W, Allen, M.D, Andreeva, A, Fersht, A.R, Bycroft, M. | Deposit date: | 2005-11-08 | Release date: | 2006-01-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution Structure of the C4 Zinc Finger Domain of Hdm2. Protein Sci., 15, 2006
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2FEJ
| Solution structure of human p53 DNA binding domain. | Descriptor: | Cellular tumor antigen p53, ZINC ION | Authors: | Perez-Canadillas, J.M, Tidow, H, Freund, S.M, Rutherford, T.J, Ang, H.C, Fersht, A.R. | Deposit date: | 2005-12-16 | Release date: | 2006-01-31 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of p53 core domain: Structural basis for its instability Proc.Natl.Acad.Sci.Usa, 103, 2006
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1W4G
| Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state folding transitions | Descriptor: | DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE | Authors: | Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Sato, S, Fersht, A.R. | Deposit date: | 2004-07-23 | Release date: | 2005-07-20 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family. J.Mol.Biol., 353, 2005
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1W4F
| Peripheral-subunit from mesophilic, thermophilic and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions | Descriptor: | DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE | Authors: | Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Fersht, A.R. | Deposit date: | 2004-07-23 | Release date: | 2005-07-20 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family. J.Mol.Biol., 353, 2005
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1W4H
| Peripheral-subunit from mesophilic, thermophilic and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions | Descriptor: | DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE | Authors: | Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Fersht, A.R. | Deposit date: | 2004-07-23 | Release date: | 2005-07-20 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Ultra-Fast Barrier-Limited Folding in the Peripheral Subunit-Binding Domain Family. J.Mol.Biol., 353, 2005
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1W4J
| Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions | Descriptor: | PYRUVATE DEHYDROGENASE E2 | Authors: | Ferguson, N, Sharpe, T.D, Schartau, P.J, Allen, M.D, Johnson, C.M, Sato, S, Fersht, A.R. | Deposit date: | 2004-07-23 | Release date: | 2005-07-20 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family. J. Mol. Biol., 353, 2005
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