5CWI
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4M6L
| Crystal structure of human dihydrofolate reductase (DHFR) bound to NADP+ and 5,10-dideazatetrahydrofolic acid | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Dihydrofolate reductase, N-(4-{2-[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl}benzoyl)-L-glutamic acid, ... | 著者 | Bhabha, G, Ekiert, D.C, Wright, P.E, Wilson, I.A. | 登録日 | 2013-08-09 | 公開日 | 2013-09-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Divergent evolution of protein conformational dynamics in dihydrofolate reductase. Nat.Struct.Mol.Biol., 20, 2013
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4M6J
| Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH | 分子名称: | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Bhabha, G, Ekiert, D.C, Wright, P.E, Wilson, I.A. | 登録日 | 2013-08-09 | 公開日 | 2013-09-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.201 Å) | 主引用文献 | Divergent evolution of protein conformational dynamics in dihydrofolate reductase. Nat.Struct.Mol.Biol., 20, 2013
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4M6K
| Crystal structure of human dihydrofolate reductase (DHFR) bound to NADP+ and folate | 分子名称: | Dihydrofolate reductase, FOLIC ACID, GLYCEROL, ... | 著者 | Bhabha, G, Ekiert, D.C, Wright, P.E, Wilson, I.A. | 登録日 | 2013-08-09 | 公開日 | 2013-09-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.396 Å) | 主引用文献 | Divergent evolution of protein conformational dynamics in dihydrofolate reductase. Nat.Struct.Mol.Biol., 20, 2013
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4F6N
| Crystal structure of Kaiso zinc finger DNA binding protein in complex with methylated CpG site DNA | 分子名称: | DNA (5'-D(*CP*GP*TP*AP*TP*AP*GP*AP*(5CM)P*GP*(5CM)P*GP*GP*TP*GP*AP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*TP*CP*AP*CP*(5CM)P*GP*(5CM)P*GP*TP*CP*TP*AP*TP*AP*CP*G)-3'), GLYCEROL, ... | 著者 | Buck-Koehntop, B.A, Stanfield, R.L, Ekiert, D.C, Martinez-Yamout, M.A, Dyson, H.J, Wilson, I.A, Wright, P.E. | 登録日 | 2012-05-15 | 公開日 | 2012-09-05 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso. Proc.Natl.Acad.Sci.USA, 109, 2012
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4F6M
| Crystal structure of Kaiso zinc finger DNA binding domain in complex with Kaiso binding site DNA | 分子名称: | DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*GP*GP*CP*AP*GP*GP*AP*AP*GP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*CP*TP*TP*CP*CP*TP*GP*CP*CP*AP*AP*TP*AP*AP*CP*G)-3'), Transcriptional regulator Kaiso, ... | 著者 | Buck-Koehntop, B.A, Stanfield, R.L, Ekiert, D.C, Martinez-Yamout, M.A, Dyson, H.J, Wilson, I.A, Wright, P.E. | 登録日 | 2012-05-15 | 公開日 | 2012-09-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso. Proc.Natl.Acad.Sci.USA, 109, 2012
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4GMS
| Crystal structure of heterosubtypic Fab S139/1 in complex with influenza A H3 hemagglutinin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab S139/1 heavy chain, ... | 著者 | Lee, P.S, Ekiert, D.C, Wilson, I.A. | 登録日 | 2012-08-16 | 公開日 | 2012-10-03 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity. Proc.Natl.Acad.Sci.USA, 109, 2012
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4GMT
| Crystal structure of heterosubtypic Fab S139/1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab S139/1 heavy chain, ... | 著者 | Lee, P.S, Ekiert, D.C, Wilson, I.A. | 登録日 | 2012-08-16 | 公開日 | 2012-10-03 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity. Proc.Natl.Acad.Sci.USA, 109, 2012
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6WYR
| Crystal structure of anti-Muscle Specific Kinase (MuSK) Fab, MuSK1A | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MuSK1A heavy chain, ... | 著者 | Vieni, C, Ekiert, D. | 登録日 | 2020-05-13 | 公開日 | 2020-07-29 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Affinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis. J.Exp.Med., 217, 2020
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6WYT
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7MI6
| Yeast dynein motor domain in the presence of a pyrazolo-pyrimidinone-based compound, Model 1 | 分子名称: | (8S)-6-(3-bromophenoxy)-2-[1-(4-chlorophenyl)cyclopropyl]-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile, ADENOSINE-5'-TRIPHOSPHATE, Fusion protein of Dynein and Endolysin, ... | 著者 | Santarossa, C.C, Urnavicius, L, Coudray, N, Ekeirt, D.C, Bhabha, G, Kapoor, T.M. | 登録日 | 2021-04-16 | 公開日 | 2021-05-26 | 最終更新日 | 2021-11-03 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Targeting allostery in the Dynein motor domain with small molecule inhibitors. Cell Chem Biol, 28, 2021
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7SEE
| Structure of E. coli LetB delta (Ring6) mutant, Ring1 in the closed state (Model 1) | 分子名称: | MCE family protein, Intermembrane transport protein YebT chimera, UNKNOWN ATOM OR ION | 著者 | Vieni, C, Coudray, N, Bhabha, G, Ekiert, D. | 登録日 | 2021-09-30 | 公開日 | 2022-02-09 | 最終更新日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Role of Ring6 in the Function of the E. coli MCE Protein LetB. J.Mol.Biol., 434, 2022
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7SEF
| Structure of E. coli LetB delta (Ring6) mutant, Ring 1 in the open state (Model 2, Rings 1-3 only) | 分子名称: | MCE family protein, Intermembrane transport protein YebT chimera | 著者 | Vieni, C, Coudray, N, Bhabha, G, Ekiert, D. | 登録日 | 2021-09-30 | 公開日 | 2022-02-09 | 最終更新日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | 主引用文献 | Role of Ring6 in the Function of the E. coli MCE Protein LetB. J.Mol.Biol., 434, 2022
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7UDJ
| Crystal structure of designed helical repeat protein RPB_PEW3_R4 bound to PAWx4 peptide | 分子名称: | 4xPAW peptide, De novo designed helical repeat protein RPB_PEW3_R4 | 著者 | Redler, R.L, Chang, Y, Bhabha, G, Ekiert, D. | 登録日 | 2022-03-20 | 公開日 | 2023-03-22 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | De novo design of modular peptide-binding proteins by superhelical matching. Nature, 616, 2023
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8SMQ
| Crystal Structure of the N-terminal Domain of the Cryptic Surface Protein (CD630_25440) from Clostridium difficile. | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... | 著者 | Minasov, G, Shuvalova, L, Brunzelle, J.S, Kiryukhina, O, Wawrzak, Z, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID), Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2023-04-26 | 公開日 | 2023-05-10 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Protein target highlights in CASP15: Analysis of models by structure providers. Proteins, 91, 2023
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3LZG
| Crystal structure of a 2009 H1N1 influenza virus hemagglutinin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | 著者 | Xu, R, Wilson, I.A. | 登録日 | 2010-03-01 | 公開日 | 2010-04-14 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus. Science, 328, 2010
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5J8E
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4NM8
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4NM4
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4W7G
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4HLZ
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4FQM
| Structure of B/Brisbane/60/2008 Influenza Hemagglutinin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, ... | 著者 | Dreyfus, C, Laursen, N.S, Wilson, I.A. | 登録日 | 2012-06-25 | 公開日 | 2012-08-22 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | Highly conserved protective epitopes on influenza B viruses. Science, 337, 2012
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4FQL
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4FQH
| Crystal Structure of Fab CR9114 | 分子名称: | 1,2-ETHANEDIOL, NITRATE ION, antibody CR9114 heavy chain, ... | 著者 | Dreyfus, C, Wilson, I.A. | 登録日 | 2012-06-25 | 公開日 | 2012-08-22 | 最終更新日 | 2018-01-31 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Highly conserved protective epitopes on influenza B viruses. Science, 337, 2012
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4FQK
| Influenza B/Brisbane/60/2008 hemagglutinin Fab CR8059 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody CR8059 Heavy Chain, ... | 著者 | Dreyfus, C, Laursen, N.S, Wilson, I.A. | 登録日 | 2012-06-25 | 公開日 | 2012-08-22 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (5.65 Å) | 主引用文献 | Highly conserved protective epitopes on influenza B viruses. Science, 337, 2012
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