1ITG
| CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES | Descriptor: | CACODYLATE ION, HIV-1 INTEGRASE | Authors: | Dyda, F, Hickman, A.B, Jenkins, T.M, Engelman, A, Craigie, R, Davies, D.R. | Deposit date: | 1994-11-21 | Release date: | 1995-05-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases. Science, 266, 1994
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1PYD
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6B67
| Human PP2Calpha (PPM1A) complexed with cyclic peptide c(MpSIpYVA) | Descriptor: | CALCIUM ION, Protein phosphatase 1A, cyclic peptide c(MpSIpYVA) | Authors: | Dyda, F, Kosek, D. | Deposit date: | 2017-10-01 | Release date: | 2018-04-11 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A trapped human PPM1A-phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity. J. Biol. Chem., 293, 2018
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1UUT
| The Nuclease Domain of Adeno-Associated Virus Rep Complexed with the RBE' Stemloop of the Viral Inverted Terminal Repeat | Descriptor: | 5'-D(*CP*AP*GP*CP*TP*CP*TP*TP*TP*GP *AP*GP*CP*TP*G)-3', CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Dyda, F, Hickman, A.B, Ronning, D.R, Perez, Z.N, Kotin, R.M. | Deposit date: | 2004-01-10 | Release date: | 2004-02-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Nuclease Domain of Adeno-Associated Virus Rep Coordinates Replication Initiation Using Two Distinct DNA Recognition Interfaces Mol.Cell, 13, 2004
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9AZ7
| Chloride Sites in Photoactive Yellow Protein | Descriptor: | 4'-HYDROXYCINNAMIC ACID, CHLORIDE ION, Photoactive yellow protein | Authors: | Dyda, F, Schotte, F, Anfinrud, P, Cho, H.S. | Deposit date: | 2024-03-10 | Release date: | 2024-03-20 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Watching a signaling protein function: What has been learned over four decades of time-resolved studies of photoactive yellow protein. Struct Dyn., 11, 2024
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9AZ9
| Chloride Sites in Photoactive Yellow Protein (Chloride-Free Reference Structure) | Descriptor: | 4'-HYDROXYCINNAMIC ACID, Photoactive yellow protein | Authors: | Dyda, F, Schotte, F, Anfinrud, P, Cho, H.S. | Deposit date: | 2024-03-10 | Release date: | 2024-03-20 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Watching a signaling protein function: What has been learned over four decades of time-resolved studies of photoactive yellow protein. Struct Dyn., 11, 2024
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6OPM
| Casposase bound to integration product | Descriptor: | CALCIUM ION, CRISPR-associated endonuclease Cas1, DNA 21-mer, ... | Authors: | Dyda, F, Hickman, A.B, Kailasan, S. | Deposit date: | 2019-04-25 | Release date: | 2020-02-12 | Last modified: | 2020-08-26 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas. Elife, 9, 2020
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6DWZ
| Hermes transposase deletion dimer complex with (C/G) DNA | Descriptor: | DNA (26-MER), DNA (5'-D(*GP*AP*GP*AP*AP*CP*AP*AP*CP*AP*AP*CP*AP*AP*G)-3'), DNA (5'-D(*GP*CP*GP*TP*GP*AP*C)-3'), ... | Authors: | Dyda, F, Hickman, A.B. | Deposit date: | 2018-06-28 | Release date: | 2018-09-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural insights into the mechanism of double strand break formation by Hermes, a hAT family eukaryotic DNA transposase. Nucleic Acids Res., 46, 2018
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6DWW
| Hermes transposase deletion dimer complex with (A/T) DNA and Mn2+ | Descriptor: | DNA (25-MER), DNA (5'-D(*AP*GP*AP*GP*AP*AP*CP*AP*AP*CP*AP*AP*CP*AP*AP*G)-3'), DNA (5'-D(*GP*CP*GP*TP*GP*AP*A)-3'), ... | Authors: | Dyda, F, Voth, A.R, Hickman, A.B. | Deposit date: | 2018-06-28 | Release date: | 2018-09-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.851 Å) | Cite: | Structural insights into the mechanism of double strand break formation by Hermes, a hAT family eukaryotic DNA transposase. Nucleic Acids Res., 46, 2018
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6DX0
| Hermes transposase deletion dimer complex with (A/T) DNA | Descriptor: | DNA (25-MER), DNA (5'-D(*AP*GP*AP*GP*AP*AP*CP*AP*AP*CP*AP*AP*CP*AP*AP*G)-3'), DNA (5'-D(*GP*CP*GP*TP*GP*AP*A)-3'), ... | Authors: | Dyda, F, Voth, A.R, Hickman, A.B. | Deposit date: | 2018-06-28 | Release date: | 2018-09-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural insights into the mechanism of double strand break formation by Hermes, a hAT family eukaryotic DNA transposase. Nucleic Acids Res., 46, 2018
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6DWY
| Hermes transposase deletion dimer complex with (C/G) DNA and Ca2+ | Descriptor: | CALCIUM ION, DNA (26-MER), DNA (5'-D(*AP*GP*AP*GP*AP*AP*CP*AP*AP*CP*AP*AP*CP*AP*AP*G)-3'), ... | Authors: | Dyda, F, Hickman, A.B. | Deposit date: | 2018-06-28 | Release date: | 2018-09-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural insights into the mechanism of double strand break formation by Hermes, a hAT family eukaryotic DNA transposase. Nucleic Acids Res., 46, 2018
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1T0F
| Crystal Structure of the TnsA/TnsC(504-555) complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, MAGNESIUM ION, MALONIC ACID, ... | Authors: | Ronning, D.R, Li, Y, Perez, Z.N, Ross, P.D, Hickman, A.B, Craig, N.L, Dyda, F. | Deposit date: | 2004-04-08 | Release date: | 2004-11-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The carboxy-terminal portion of TnsC activates the Tn7 transposase through a specific interaction with TnsA. Embo J., 23, 2004
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7TH0
| Escherichia coli RpnA-S | Descriptor: | Recombination-promoting nuclease RpnA | Authors: | Zhong, A, Hickman, A.B, Storz, G, Dyda, F. | Deposit date: | 2022-01-10 | Release date: | 2023-03-29 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Toxic antiphage defense proteins inhibited by intragenic antitoxin proteins. Proc.Natl.Acad.Sci.USA, 120, 2023
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8EB5
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8EDG
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5LME
| Specific-DNA binding activity of the cross-brace zinc finger motif of the piggyBac transposase | Descriptor: | ZINC ION, piggyBac transposase | Authors: | Morellet, N, Taylor, J.A, Wieninger, S, Moriau, S, Li, X, Lescop, E, Mathy, N, Bischerour, J, Betermier, M, Bardiaux, B, Nilges, M, Craig, N.L, Hickman, A.B, Dyda, F, Guittet, E. | Deposit date: | 2016-07-30 | Release date: | 2017-12-20 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Sequence-specific DNA binding activity of the cross-brace zinc finger motif of the piggyBac transposase. Nucleic Acids Res., 46, 2018
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8SJD
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4ER8
| Structure of the REP associates tyrosine transposase bound to a REP hairpin | Descriptor: | DNA (32-MER), NICKEL (II) ION, TnpArep for protein | Authors: | Messing, S.A.J, Ton-Hoang, B, Hickman, A.B, Ghirlando, R, Chandler, M, Dyda, F. | Deposit date: | 2012-04-19 | Release date: | 2012-08-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The processing of repetitive extragenic palindromes: the structure of a repetitive extragenic palindrome bound to its associated nuclease. Nucleic Acids Res., 40, 2012
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8T2J
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1RZ9
| Crystal Structure of AAV Rep complexed with the Rep-binding sequence | Descriptor: | 26-MER, Rep protein | Authors: | Hickman, A.B, Ronning, D.R, Perez, Z.N, Kotin, R.M, Dyda, F. | Deposit date: | 2003-12-24 | Release date: | 2004-02-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The nuclease domain of adeno-associated virus rep coordinates replication initiation using two distinct DNA recognition interfaces. Mol.Cell, 13, 2004
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7MGV
| Chryseobacterium gregarium RiPP-associated ATP-grasp ligase in complex with ADP, and a leader and core peptide | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CdnA3 Core peptide, CdnA3 Leader peptide, ... | Authors: | Bewley, C.A, Zhao, G, Kosek, D, Dyda, F. | Deposit date: | 2021-04-13 | Release date: | 2021-06-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Structural Basis for a Dual Function ATP Grasp Ligase That Installs Single and Bicyclic omega-Ester Macrocycles in a New Multicore RiPP Natural Product. J.Am.Chem.Soc., 143, 2021
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7LCC
| Helitron transposase bound to LTS | Descriptor: | Helraiser K1068Q, LTS, ZINC ION | Authors: | Kosek, D, Dyda, F. | Deposit date: | 2021-01-10 | Release date: | 2021-08-25 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | The large bat Helitron DNA transposase forms a compact monomeric assembly that buries and protects its covalently bound 5'-transposon end. Mol.Cell, 81, 2021
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1MPE
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1M55
| Catalytic domain of the Adeno Associated Virus type 5 Rep protein | Descriptor: | CHLORIDE ION, Rep protein, ZINC ION | Authors: | Hickman, A.B, Ronning, D.R, Kotin, R.M, Dyda, F. | Deposit date: | 2002-07-08 | Release date: | 2002-08-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep. Mol.Cell, 10, 2002
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1MVK
| X-ray structure of the tetrameric mutant of the B1 domain of streptococcal protein G | Descriptor: | Immunoglobulin G binding protein G, SULFATE ION | Authors: | Frank, M.K, Dyda, F, Dobrodumov, A, Gronenborn, A.M. | Deposit date: | 2002-09-25 | Release date: | 2002-10-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Core mutations switch monomeric protein GB1 into an intertwined tetramer. Nat.Struct.Biol., 9, 2002
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