7TYG
 
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9BTP
 | | Structure of human SHOC2 in complex with a small molecule inhibitor (R)-5 | | Descriptor: | (2S)-{2-[(4-chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl}[(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)amino]acetic acid, Leucine-rich repeat protein SHOC-2, POTASSIUM ION | | Authors: | Dhembi, A, Hauseman, Z.J, King, D. | | Deposit date: | 2024-05-15 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-21 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Targeting the SHOC2-RAS interaction in RAS-mutant cancers.
Nature, 2025
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7TXH
 | | Human MRas Q71R in complex with human Shoc2 LRR domain M173I and human PP1Ca | | Descriptor: | GLYCEROL, Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, ... | | Authors: | Hauseman, Z.J, Viscomi, J, Dhembi, A, Clark, K, King, D.A, Fodor, M. | | Deposit date: | 2022-02-09 | | Release date: | 2022-06-22 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure of the MRAS-SHOC2-PP1C phosphatase complex.
Nature, 609, 2022
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9BTN
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9DCW
 | | FKBP1a (FKBP12) co-crystal structure with macrocycle molecular glue | | Descriptor: | (5S,14R,16aS,21R,28S,30aR)-14-[2-(3,4-dimethoxyphenyl)ethyl]-24,24,28-trimethyl-2-methylidene-1,3,4,17,18,19,20,24,25,28,29,30a-dodecahydro-2H,14H-9,13-(metheno)dipyrido[1,2-d:1',2'-o][1,10,18,4,7,15]trioxatriazacyclotetracosine-6,16,22,23,27,30(7H,16aH)-hexone, Peptidyl-prolyl cis-trans isomerase FKBP1A | | Authors: | Salcius, M.J, King, D.A, Clark, K. | | Deposit date: | 2024-08-27 | | Release date: | 2025-03-26 | | Last modified: | 2025-05-21 | | Method: | X-RAY DIFFRACTION (1.721 Å) | | Cite: | Identification and characterization of ternary complexes consisting of FKBP12, MAPRE1 and macrocyclic molecular glues.
Rsc Chem Biol, 6, 2025
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9CO5
 | | Crystal Structure of Macrocycle mediated complex of FKBP12 and MAPRE1 | | Descriptor: | (5S,14R,16aS,21R,28S,30aR)-14-[2-(3,4-dimethoxyphenyl)ethyl]-24,24,28-trimethyl-2-methylidene-1,3,4,17,18,19,20,24,25,28,29,30a-dodecahydro-2H,14H-9,13-(metheno)dipyrido[1,2-d:1',2'-o][1,10,18,4,7,15]trioxatriazacyclotetracosine-6,16,22,23,27,30(7H,16aH)-hexone, Microtubule-associated protein RP/EB family member 1, Peptidyl-prolyl cis-trans isomerase FKBP1A | | Authors: | King, D.A. | | Deposit date: | 2024-07-16 | | Release date: | 2025-03-26 | | Last modified: | 2025-05-21 | | Method: | X-RAY DIFFRACTION (2.77 Å) | | Cite: | Identification and characterization of ternary complexes consisting of FKBP12, MAPRE1 and macrocyclic molecular glues.
Rsc Chem Biol, 6, 2025
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9BTM
 | | NRas 1-169 Q61R in Complex with Shoc2 80-582 | | Descriptor: | GTPase NRas, GUANOSINE-5'-TRIPHOSPHATE, Leucine-rich repeat protein SHOC-2, ... | | Authors: | Hauseman, Z.J, King, D, Viscomi, J, Fodor, M. | | Deposit date: | 2024-05-15 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-21 | | Method: | X-RAY DIFFRACTION (2.73 Å) | | Cite: | Targeting the SHOC2-RAS interaction in RAS-mutant cancers.
Nature, 2025
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5V1X
 | | Carbon Sulfoxide lyase, Egt2 Y134F in complex with its substrate | | Descriptor: | (1S)-2-{2-[(R)-(2R)-2-amino-2-carboxyethanesulfinyl]-1H-imidazol-4-yl}-1-carboxy-N,N,N-trimethylethan-1-aminium, FORMIC ACID, Hercynylcysteine sulfoxide lyase | | Authors: | Irani, S, Zhang, Y. | | Deposit date: | 2017-03-02 | | Release date: | 2018-03-07 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.558 Å) | | Cite: | Snapshots of C-S Cleavage in Egt2 Reveals Substrate Specificity and Reaction Mechanism.
Cell Chem Biol, 25, 2018
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5UTS
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5V12
 | | Crystal structure of Carbon Sulfoxide lyase, Egt2 Y134F with sulfenic acid intermediate | | Descriptor: | (1S)-1-carboxy-2-[2-(hydroxysulfanyl)-1H-imidazol-4-yl]-N,N,N-trimethylethan-1-aminium, FORMIC ACID, Hercynylcysteine sulfoxide lyase | | Authors: | Irani, S, Zhang, Y. | | Deposit date: | 2017-03-01 | | Release date: | 2018-03-07 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.451 Å) | | Cite: | Snapshots of C-S Cleavage in Egt2 Reveals Substrate Specificity and Reaction Mechanism.
Cell Chem Biol, 25, 2018
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