6XIW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xiw by Molmil](/molmil-images/mine/6xiw) | Cryo-EM structure of the sodium leak channel NALCN-FAM155A complex | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kschonsak, M, Chua, H.C, Noland, C.L, Weidling, C, Clairfeuille, T, Bahlke, O.O, Ameen, A.O, Li, Z.R, Arthur, C.P, Ciferri, C, Pless, S.A, Payandeh, J. | Deposit date: | 2020-06-22 | Release date: | 2020-07-29 | Last modified: | 2020-11-25 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure of the human sodium leak channel NALCN. Nature, 587, 2020
|
|
7SX3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sx3 by Molmil](/molmil-images/mine/7sx3) | Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 1/2 | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kschonsak, M, Chua, H.C, Weidling, C, Chakouri, N, Noland, C.L, Schott, K, Chang, T, Tam, C, Patel, N, Arthur, C.P, Leitner, A, Ben-Johny, M, Ciferri, C, Pless, S.A, Payandeh, J. | Deposit date: | 2021-11-22 | Release date: | 2021-12-29 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural architecture of the human NALCN channelosome. Nature, 603, 2022
|
|
7SX4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sx4 by Molmil](/molmil-images/mine/7sx4) | Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 2/2 | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kschonsak, M, Chua, H.C, Weidling, C, Chakouri, N, Noland, C.L, Schott, K, Chang, T, Tam, C, Patel, N, Arthur, C.P, Leitner, A, Ben-Johny, M, Ciferri, C, Pless, S.A, Payandeh, J. | Deposit date: | 2021-11-22 | Release date: | 2021-12-29 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural architecture of the human NALCN channelosome. Nature, 603, 2022
|
|
7TJ8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7tj8 by Molmil](/molmil-images/mine/7tj8) | Cryo-EM structure of the human Nax channel in complex with beta3 solved in nanodiscs | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Noland, C.L, Kschonsak, M, Ciferri, C, Payandeh, J. | Deposit date: | 2022-01-14 | Release date: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure-guided unlocking of Na X reveals a non-selective tetrodotoxin-sensitive cation channel. Nat Commun, 13, 2022
|
|
7TJ9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7tj9 by Molmil](/molmil-images/mine/7tj9) | Cryo-EM structure of the human Nax channel in complex with beta3 solved in GDN | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Noland, C.L, Kschonsak, M, Ciferri, C, Payandeh, J. | Deposit date: | 2022-01-14 | Release date: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure-guided unlocking of Na X reveals a non-selective tetrodotoxin-sensitive cation channel. Nat Commun, 13, 2022
|
|
7C8S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7c8s by Molmil](/molmil-images/mine/7c8s) | Crystal structure of DUSP22 mutant_N128A | Descriptor: | Dual specificity protein phosphatase 22, SULFATE ION | Authors: | Lai, C.H, Lyu, P.C. | Deposit date: | 2020-06-03 | Release date: | 2020-10-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases. Int J Mol Sci, 21, 2020
|
|
6L1S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6l1s by Molmil](/molmil-images/mine/6l1s) | Crystal structure of DUSP22 mutant_C88S | Descriptor: | Dual specificity protein phosphatase 22, PHOSPHATE ION | Authors: | Lai, C.H, Chang, C.C, Lyu, P.C. | Deposit date: | 2019-09-30 | Release date: | 2020-10-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.3611 Å) | Cite: | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases. Int J Mol Sci, 21, 2020
|
|
6LMY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lmy by Molmil](/molmil-images/mine/6lmy) | Crystal structure of DUSP22 mutant_C88S/S93A | Descriptor: | Dual specificity protein phosphatase 22, PHOSPHATE ION | Authors: | Lai, C.H, Lyu, P.C. | Deposit date: | 2019-12-27 | Release date: | 2020-10-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases. Int J Mol Sci, 21, 2020
|
|
6LOT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lot by Molmil](/molmil-images/mine/6lot) | Crystal structure of DUSP22 mutant_N128D | Descriptor: | Dual specificity protein phosphatase 22, SULFATE ION | Authors: | Lai, C.H, Lyu, P.C. | Deposit date: | 2020-01-07 | Release date: | 2020-10-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases. Int J Mol Sci, 21, 2020
|
|
6LOU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lou by Molmil](/molmil-images/mine/6lou) | Crystal structure of DUSP22 mutant_C88S/S93N | Descriptor: | Dual specificity protein phosphatase 22, PHOSPHATE ION | Authors: | Lai, C.H, Lyu, P.C. | Deposit date: | 2020-01-07 | Release date: | 2020-10-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.5301 Å) | Cite: | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases. Int J Mol Sci, 21, 2020
|
|
6LVQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lvq by Molmil](/molmil-images/mine/6lvq) | Crystal structure of DUSP22_VO4 | Descriptor: | Dual specificity protein phosphatase 22, VANADATE ION | Authors: | Lai, C.H, Lyu, P.C. | Deposit date: | 2020-02-04 | Release date: | 2020-10-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases. Int J Mol Sci, 21, 2020
|
|