1MHW
 
 | | Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides | | Descriptor: | 4-biphenylacetyl-Cys-(D)Arg-Tyr-N-(2-phenylethyl) amide, Cathepsin L | | Authors: | Chowdhury, S, Sivaraman, J, Wang, J, Devanathan, G, Lachance, P, Qi, H, Menard, R, Lefebvre, J, Konishi, Y, Cygler, M, Sulea, T, Purisima, E.O. | | Deposit date: | 2002-08-21 | | Release date: | 2002-12-11 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides
J.Med.Chem., 45, 2002
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2GIP
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2GIO
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5UZ9
 | | Cryo EM structure of anti-CRISPRs, AcrF1 and AcrF2, bound to type I-F crRNA-guided CRISPR surveillance complex | | Descriptor: | Anti-CRISPR protein 30, Anti-CRISPR protein Acr30-35, CRISPR RNA (60-MER), ... | | Authors: | Chowdhury, S, Carter, J, Rollins, M.F, Jackson, R.N, Hoffmann, C, Nosaka, L, Bondy-Denomy, J, Maxwell, K.L, Davidson, A.R, Fischer, E.R, Lander, G.C, Wiedenheft, B. | | Deposit date: | 2017-02-25 | | Release date: | 2017-04-26 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex.
Cell, 169, 2017
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8U7R
 | | WT sea urchin SLC9C1 at pH 6 in presence of K+ | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Digitonin, Sperm-specific sodium proton exchanger | | Authors: | Chowdhury, S, Pal, K. | | Deposit date: | 2023-09-15 | | Release date: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | WT sea urchin SLC9C1 at pH 6 in presence of K+
To Be Published
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8U7D
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8U71
 | | Structure of sea urchin SLC9C1 at pH 8 in Na+ | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Digitonin, Sperm-specific sodium proton exchanger | | Authors: | Chowdhury, S, Pal, K. | | Deposit date: | 2023-09-14 | | Release date: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | SLC9C1 at pH 8 in presence of K+
To Be Published
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8U75
 | | R399A mutant of sea urchin SLC9C1 at pH 6 in Na+ - Compressed state | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Digitonin, Sperm-specific sodium proton exchanger | | Authors: | Chowdhury, S, Pal, K. | | Deposit date: | 2023-09-14 | | Release date: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | R399A mutant of sea urchin SLC9C1 at pH 6 in presence of Na+ - Compressed Form
To Be Published
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8U6Z
 | | SLC9C1 at pH 8 in presence of K+ | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Digitonin, Sperm-specific sodium proton exchanger | | Authors: | Chowdhury, S, Pal, K. | | Deposit date: | 2023-09-14 | | Release date: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | SLC9C1 at pH 8 in presence of K+
To Be Published
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8U7O
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8U7S
 | | SLC9C1 at pH 6 in presence of Na+ | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Digitonin, Sperm-specific sodium proton exchanger | | Authors: | Chowdhury, S, Pal, K. | | Deposit date: | 2023-09-15 | | Release date: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (4.18 Å) | | Cite: | SLC9C1 at pH 6 in presence of Na+
To Be Published
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8U7K
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8U73
 | | R399A sea urchin SLC9C1 pH 8 in Na+ | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Digitonin, Sperm-specific sodium proton exchanger | | Authors: | Chowdhury, S, Pal, K. | | Deposit date: | 2023-09-14 | | Release date: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structure of R399A mutant of sea urchin SLC9C1 at pH 8 in Na+
To Be Published
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8U7P
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6NE0
 | | Structure of double-stranded target DNA engaged Csy complex from Pseudomonas aeruginosa (PA-14) | | Descriptor: | CRISPR RNA (60-MER), CRISPR target DNA (44-MER), CRISPR-associated endonuclease Cas6/Csy4, ... | | Authors: | Chowdhury, S, Rollins, M.F, Carter, J, Golden, S.M, Miettinen, H.M, Santiago-Frangos, A, Faith, D, Lawrence, M.C, Wiedenheft, B, Lander, G.C. | | Deposit date: | 2018-12-15 | | Release date: | 2018-12-26 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure Reveals a Mechanism of CRISPR-RNA-Guided Nuclease Recruitment and Anti-CRISPR Viral Mimicry.
Mol. Cell, 74, 2019
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3SJN
 | | Crystal structure of enolase Spea_3858 (target EFI-500646) from Shewanella pealeana with magnesium bound | | Descriptor: | GLYCEROL, MAGNESIUM ION, Mandelate racemase/muconate lactonizing protein, ... | | Authors: | Patskovsky, Y, Kim, J, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | | Deposit date: | 2011-06-21 | | Release date: | 2011-07-06 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal Structure of Enolase Spea_3858 from Shewanella Pealeana
To be Published
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4DO7
 | | Crystal structure of an amidohydrolase (cog3618) from burkholderia multivorans (target efi-500235) with bound zn, space group c2 | | Descriptor: | Amidohydrolase 2, SULFATE ION, ZINC ION | | Authors: | Vetting, M.W, Toro, R, Bhosle, R, Wasserman, S.R, Morisco, L.L, Sojitra, S, Seidel, R.D, Hillerich, B, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Al Obaidi, N.F, Zencheck, W.D, Imker, H.J, Gerlt, J.A, Raushel, F.M, Almo, S.C, Enzyme Function Initiative (EFI) | | Deposit date: | 2012-02-09 | | Release date: | 2012-02-29 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of an amidohydrolase (cog3618) from burkholderia multivorans (target efi-500235) with bound zn, space group c2
to be published
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4DFD
 | | Crystal structure of had family enzyme bt-2542 (target efi-501088) from bacteroides thetaiotaomicron, magnesium complex | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Putative haloacid dehalogenase-like hydrolase, ... | | Authors: | Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Gerlt, J.A, Allen, K, Dunaway-Mariano, D, Almo, S.C, Enzyme Function Initiative (EFI) | | Deposit date: | 2012-01-23 | | Release date: | 2012-02-01 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of Protein Bt-2542 from Bacteroides Thetaiotaomicron (Target Efi-501088)
To be Published
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6W18
 | | Structure of S. pombe Arp2/3 complex in inactive state | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1, ... | | Authors: | Shaaban, M, Nolen, B.J, Chowdhury, S. | | Deposit date: | 2020-03-03 | | Release date: | 2020-08-12 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state.
Nat.Struct.Mol.Biol., 27, 2020
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6W17
 | | Structure of Dip1-activated Arp2/3 complex with nucleated actin filament | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | | Authors: | Shaaban, M, Nolen, B.J, Chowdhury, S. | | Deposit date: | 2020-03-03 | | Release date: | 2020-08-12 | | Last modified: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Cryo-EM reveals the transition of Arp2/3 complex from inactive to nucleation-competent state.
Nat.Struct.Mol.Biol., 27, 2020
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3M0E
 | | Crystal structure of the ATP-bound state of Walker B mutant of NtrC1 ATPase domain | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Transcriptional regulator (NtrC family) | | Authors: | Chen, B, Sysoeva, T.A, Chowdhury, S, Rusu, M, Birmanns, S, Guo, L, Hanson, J, Yang, H, Nixon, B.T. | | Deposit date: | 2010-03-02 | | Release date: | 2010-11-03 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.63 Å) | | Cite: | Engagement of Arginine Finger to ATP Triggers Large Conformational Changes in NtrC1 AAA+ ATPase for Remodeling Bacterial RNA Polymerase.
Structure, 18, 2010
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9BSN
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9C09
 | | Structure of K2P13.1 (THIK1) S136P in lipid nanodisc | | Descriptor: | DECANE, DODECANE, HEXANE, ... | | Authors: | Roy-Chowdhury, S, Adberemane-Ali, F, Minor, D.L. | | Deposit date: | 2024-05-24 | | Release date: | 2025-02-26 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.36 Å) | | Cite: | Structure of the human K 2P 13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.
Nat.Struct.Mol.Biol., 32, 2025
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9BYI
 | | Structure of human K2P13.1 (THIK1) in detergent | | Descriptor: | DODECANE, HEXADECANE, HEXANE, ... | | Authors: | Roy-Chowdhury, S, Minor, D.L. | | Deposit date: | 2024-05-23 | | Release date: | 2025-02-26 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Structure of the human K 2P 13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.
Nat.Struct.Mol.Biol., 32, 2025
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9BWS
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