1D9X
| CRYSTAL STRUCTURE OF THE DNA REPAIR PROTEIN UVRB | 分子名称: | EXCINUCLEASE UVRABC COMPONENT UVRB, ZINC ION | 著者 | Theis, K, Chen, P.J, Skorvaga, M, Van Houten, B, Kisker, C. | 登録日 | 1999-10-30 | 公開日 | 2000-05-03 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of UvrB, a DNA helicase adapted for nucleotide excision repair. EMBO J., 18, 1999
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1D9Z
| CRYSTAL STRUCTURE OF THE DNA REPAIR PROTEIN UVRB IN COMPLEX WITH ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, EXCINUCLEASE UVRABC COMPONENT UVRB, MAGNESIUM ION, ... | 著者 | Theis, K, Chen, P.J, Skorvaga, M, Van Houten, B, Kisker, C. | 登録日 | 1999-10-30 | 公開日 | 2000-05-03 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Crystal structure of UvrB, a DNA helicase adapted for nucleotide excision repair. EMBO J., 18, 1999
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8TNR
| Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 2 | 分子名称: | 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | 登録日 | 2023-08-02 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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8TNP
| Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40 | 分子名称: | DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, Protein cereblon, ... | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | 登録日 | 2023-08-02 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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8TNQ
| Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 1 | 分子名称: | 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | 登録日 | 2023-08-02 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science, 383, 2024
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7UR9
| SARS-Cov2 Main protease in complex with inhibitor CDD-1845 | 分子名称: | (2P)-2-(isoquinolin-4-yl)-1-[4-(methylamino)-4-oxobutyl]-N-[(1S)-1-(naphthalen-2-yl)ethyl]-1H-benzimidazole-7-carboxamide, 3C-like proteinase nsp5 | 著者 | Lu, S, Palzkill, T. | 登録日 | 2022-04-21 | 公開日 | 2023-07-26 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors. Commun Chem, 6, 2023
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7US4
| Sars-Cov2 Main Protease in complex with CDD-1819 | 分子名称: | (2P)-2-(isoquinolin-4-yl)-1-[(1s,3R)-3-(methylcarbamoyl)cyclobutyl]-N-[(1S)-1-(naphthalen-2-yl)ethyl]-1H-benzimidazole-7-carboxamide, 3C-like proteinase | 著者 | Lu, S, Palzkill, T, Matzuk, M.M, Judge, A. | 登録日 | 2022-04-22 | 公開日 | 2023-07-26 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors. Commun Chem, 6, 2023
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7URB
| Sars-Cov2 Main Protease in complex with CDD-1733 | 分子名称: | (2P)-2-(isoquinolin-4-yl)-1-[(1s,3R)-3-(methylcarbamoyl)cyclobutyl]-N-{(1S)-1-[4-(trifluoromethyl)phenyl]butyl}-1H-benzimidazole-7-carboxamide, 3C-like proteinase | 著者 | Lu, S, Palzkill, T, Matzuk, M.M, Judge, A. | 登録日 | 2022-04-21 | 公開日 | 2023-07-26 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors. Commun Chem, 6, 2023
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4YWZ
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8E8V
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8E8T
| Structure of the short LOR domain of human AASS | 分子名称: | Alpha-aminoadipic semialdehyde synthase, mitochondrial | 著者 | Khamrui, S, Lazarus, M.B. | 登録日 | 2022-08-25 | 公開日 | 2022-10-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1. Open Biology, 12, 2022
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8E8U
| Structure of the LOR domain of human AASS | 分子名称: | Alpha-aminoadipic semialdehyde synthase, mitochondrial, MAGNESIUM ION | 著者 | Khamrui, S, Lazarus, M.B. | 登録日 | 2022-08-25 | 公開日 | 2022-10-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1. Open Biology, 12, 2022
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8KE2
| PylRS C-terminus domain mutant bound with L-3-trifluoromethylphenylalanine and AMPNP | 分子名称: | (2S)-2-azanyl-3-[3-(trifluoromethyl)phenyl]propanoic acid, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | 登録日 | 2023-08-11 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.19639969 Å) | 主引用文献 | Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids. Front Genet, 14, 2023
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8KE4
| PylRS C-terminus domain mutant bound with D-3-bromophenylalanine and AMPNP | 分子名称: | (2R)-2-azanyl-3-(3-bromophenyl)propanoic acid, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | 登録日 | 2023-08-11 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.75050962 Å) | 主引用文献 | Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids. Front Genet, 14, 2023
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8KE3
| PylRS C-terminus domain mutant bound with D-3-trifluoromethylphenylalanine and AMPNP | 分子名称: | (2R)-2-azanyl-3-[3-(trifluoromethyl)phenyl]propanoic acid, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | 登録日 | 2023-08-11 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.89980984 Å) | 主引用文献 | Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids. Front Genet, 14, 2023
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8KE6
| PylRS C-terminus domain mutant bound with L-3-chlorophenylalanine and AMPNP | 分子名称: | 3-CHLORO-L-PHENYLALANINE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | 登録日 | 2023-08-11 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.89570856 Å) | 主引用文献 | Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids. Front Genet, 14, 2023
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8KE1
| PylRS C-terminus domain mutant bound with L-3-bromophenylalanine and AMPNP | 分子名称: | 3-bromo-L-phenylalanine, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | 登録日 | 2023-08-11 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.50081539 Å) | 主引用文献 | Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids. Front Genet, 14, 2023
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8KE5
| PylRS C-terminus domain mutant bound with D-3-chlorophenylalanine and AMPNP | 分子名称: | (2R)-2-azanyl-3-(3-chlorophenyl)propanoic acid, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | 登録日 | 2023-08-11 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.900073 Å) | 主引用文献 | Rational design of the genetic code expansion toolkit for in vivo encoding of D-amino acids. Front Genet, 14, 2023
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6AEZ
| Crystal structure of human CCL5 trimer | 分子名称: | C-C motif chemokine 5, SULFATE ION | 著者 | Chen, Y.C, Li, K.M, Chen, P.J, Zarivach, R, Sun, Y.J, Sue, S.C. | 登録日 | 2018-08-07 | 公開日 | 2019-08-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Integrative Model to Coordinate the Oligomerization and Aggregation Mechanisms of CCL5. J.Mol.Biol., 432, 2020
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6LY6
| PylRS C-terminus domain mutant bound with 3-(1-Naphthyl)-L-alanine and AMPNP | 分子名称: | MAGNESIUM ION, NAPHTHALEN-2-YL-3-ALANINE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | 登録日 | 2020-02-13 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5001328 Å) | 主引用文献 | Probing the Active Site of Deubiquitinase USP30 with Noncanonical Tryptophan Analogues. Biochemistry, 59, 2020
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6LY3
| PylRS C-terminus domain mutant bound with 3-Benzothienyl-L-alanine and AMPNP | 分子名称: | 3-(1-benzothiophen-3-yl)-L-alanine, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | 登録日 | 2020-02-13 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.89590144 Å) | 主引用文献 | Probing the Active Site of Deubiquitinase USP30 with Noncanonical Tryptophan Analogues. Biochemistry, 59, 2020
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6LYA
| PylRS C-terminus domain mutant bound with 1-Methyl-L-tryptophan and AMPNP | 分子名称: | 1,2-ETHANEDIOL, 1-Methyl-L-tryptophan, MAGNESIUM ION, ... | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | 登録日 | 2020-02-13 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.590702 Å) | 主引用文献 | Probing the Active Site of Deubiquitinase USP30 with Noncanonical Tryptophan Analogues. Biochemistry, 59, 2020
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6LYB
| PylRS C-terminus domain mutant in complex with 3-Benzothienyl-D-alanine and AMPNP | 分子名称: | (2R)-2-azanyl-3-(1-benzothiophen-3-yl)propanoic acid, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | 登録日 | 2020-02-13 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.90366471 Å) | 主引用文献 | Probing the Active Site of Deubiquitinase USP30 with Noncanonical Tryptophan Analogues. Biochemistry, 59, 2020
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6LY7
| PylRS C-terminus domain mutant bound with 1-Formyl-L-tryptophan and AMPNP | 分子名称: | MAGNESIUM ION, N1-FORMYL-TRYPTOPHAN, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Weng, J.H, Tsai, M.D, Wang, Y.S. | 登録日 | 2020-02-13 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.09447265 Å) | 主引用文献 | Probing the Active Site of Deubiquitinase USP30 with Noncanonical Tryptophan Analogues. Biochemistry, 59, 2020
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