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4EAI
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BU of 4eai by Molmil
Co-crystal structure of an AMPK core with AMP
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
Deposit date:2012-03-22
Release date:2012-06-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.285 Å)
Cite:AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
4EAK
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BU of 4eak by Molmil
Co-crystal structure of an AMPK core with ATP
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
Deposit date:2012-03-22
Release date:2012-06-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
2KNO
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BU of 2kno by Molmil
NMR Solution Structure of SH2 Domain of the Human Tensin Like C1 Domain Containing Phosphatase (TENC1)
Descriptor: Tensin-like C1 domain-containing phosphatase
Authors:Chen, L, Feng, R, Liu, C, Zhu, G.
Deposit date:2009-08-27
Release date:2010-09-01
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:NMR Solution Structure of SH2 Domain of the Human Tensin Like C1 Domain Containing Phosphatase (TENC1)
To be Published
4EAJ
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BU of 4eaj by Molmil
Co-crystal of AMPK core with AMP soaked with ATP
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
Deposit date:2012-03-22
Release date:2012-06-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.609 Å)
Cite:AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
4EP4
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BU of 4ep4 by Molmil
Thermus thermophilus RuvC structure
Descriptor: Crossover junction endodeoxyribonuclease RuvC, GLYCEROL, MAGNESIUM ION
Authors:Chen, L, Shi, K, Yin, Z.Q, Aihara, H.
Deposit date:2012-04-17
Release date:2012-11-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Structural asymmetry in the Thermus thermophilus RuvC dimer suggests a basis for sequential strand cleavages during Holliday junction resolution.
Nucleic Acids Res., 41, 2013
4EAG
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BU of 4eag by Molmil
Co-crystal structure of an chimeric AMPK core with ATP
Descriptor: 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
Deposit date:2012-03-22
Release date:2012-06-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
4EAL
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BU of 4eal by Molmil
Co-crystal of AMPK core with ATP soaked with AMP
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
Deposit date:2012-03-22
Release date:2012-06-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.506 Å)
Cite:AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
4EP5
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BU of 4ep5 by Molmil
Thermus thermophilus RuvC structure
Descriptor: Crossover junction endodeoxyribonuclease RuvC, GLYCEROL, SULFATE ION
Authors:Chen, L, Shi, K, Yin, Z.Q, Aihara, H.
Deposit date:2012-04-17
Release date:2012-11-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural asymmetry in the Thermus thermophilus RuvC dimer suggests a basis for sequential strand cleavages during Holliday junction resolution.
Nucleic Acids Res., 41, 2013
2LHK
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BU of 2lhk by Molmil
Structural analysis of a chaperone in type III secretion system
Descriptor: L0052
Authors:Chen, L, Economou, A, Kalodimos, C.G.
Deposit date:2011-08-11
Release date:2011-12-28
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural instability tuning as a regulatory mechanism in protein-protein interactions.
Mol.Cell, 44, 2011
4FKE
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BU of 4fke by Molmil
Crystal structure of porcine aminopeptidase-N
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, L, Lin, Y.L, Peng, G, Li, F.
Deposit date:2012-06-13
Release date:2012-10-17
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for multifunctional roles of mammalian aminopeptidase N.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FKH
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BU of 4fkh by Molmil
Crystal structure of porcine aminopeptidase-N complexed with alanine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, L, Lin, Y.L, Peng, G, Li, F.
Deposit date:2012-06-13
Release date:2012-10-17
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for multifunctional roles of mammalian aminopeptidase N.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FKK
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BU of 4fkk by Molmil
Crystal structure of porcine aminopeptidase-N complexed with bestatin
Descriptor: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, L, Lin, Y.L, Peng, G, Li, F.
Deposit date:2012-06-13
Release date:2012-10-17
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for multifunctional roles of mammalian aminopeptidase N.
Proc.Natl.Acad.Sci.USA, 109, 2012
2M1N
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BU of 2m1n by Molmil
Solution structure of a chaperone in type III secretion system
Descriptor: Type III secretion system filament chaperone CesA
Authors:Chen, L, Economou, A, Kalodimos, C.
Deposit date:2012-12-03
Release date:2013-04-10
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Substrate-Activated Conformational Switch on Chaperones Encodes a Targeting Signal in Type III Secretion.
Cell Rep, 3, 2013
3JUA
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BU of 3jua by Molmil
Structural basis of YAP recognition by TEAD4 in the Hippo pathway
Descriptor: 65 kDa Yes-associated protein, Transcriptional enhancer factor TEF-3
Authors:Chen, L, Song, H.
Deposit date:2009-09-15
Release date:2010-02-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of YAP recognition by TEAD4 in the hippo pathway.
Genes Dev., 24, 2010
3LLP
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BU of 3llp by Molmil
1.8 Angstrom human fascin 1 crystal structure
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BROMIDE ION, Fascin, ...
Authors:Chen, L, Yang, S, Jakoncic, J, Zhang, J.J, Huang, X.-Y.
Deposit date:2010-01-29
Release date:2010-04-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Migrastatin analogues target fascin to block tumour metastasis.
Nature, 464, 2010
3R0M
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BU of 3r0m by Molmil
Crystal structure of anti-HIV llama VHH antibody A12
Descriptor: Llama VHH A12, SULFATE ION
Authors:Chen, L, McLellan, J.S, Kwon, Y.D, Schmidt, S, Wu, X, Zhou, T, Yang, Y, Zhang, B, Forsman, A, Weiss, R.A, Verrips, T, Mascola, J, Kwong, P.D.
Deposit date:2011-03-08
Release date:2012-03-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Single-Headed Immunoglobulins Efficiently Penetrate CD4-Binding Site and Effectively Neutralize HIV-1
To be Published
3RJQ
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BU of 3rjq by Molmil
Crystal structure of anti-HIV llama VHH antibody A12 in complex with C186 gp120
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, C186 gp120, Llama VHH A12
Authors:Chen, L, McLellan, J.S, Kwon, Y.D, Schmidt, S, Wu, X, Zhou, T, Yang, Y, Zhang, B, Forsman, A, Weiss, R.A, Verrips, T, Mascola, J, Kwong, P.D.
Deposit date:2011-04-15
Release date:2012-05-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Crystal structure of anti-HIV A12 VHH of llama antibody in complex with C1086 gp120
To be Published
3MCA
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BU of 3mca by Molmil
Structure of the Dom34-Hbs1 Complex and implications for its role in No-Go decay
Descriptor: Elongation factor 1 alpha-like protein, Protein dom34
Authors:Chen, L, Song, H.
Deposit date:2010-03-28
Release date:2010-10-06
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Structure of the Dom34-Hbs1 complex and implications for no-go decay
Nat.Struct.Mol.Biol., 17, 2010
4HOM
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BU of 4hom by Molmil
Crystal structure of porcine aminopeptidase-N complexed with substance P
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, L, Lin, Y.L, Peng, G, Li, F.
Deposit date:2012-10-22
Release date:2012-10-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for multifunctional roles of mammalian aminopeptidase N.
Proc.Natl.Acad.Sci.USA, 109, 2012
4NAQ
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BU of 4naq by Molmil
Crystal structure of porcine aminopeptidase-N complexed with poly-alanine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ...
Authors:Chen, L, Lin, Y.L, Peng, G, Li, F.
Deposit date:2013-10-22
Release date:2013-12-04
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for multifunctional roles of mammalian aminopeptidase N.
Proc.Natl.Acad.Sci.USA, 109, 2012
4NZ8
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BU of 4nz8 by Molmil
Crystal structure of porcine aminopeptidase-N complexed with cleaved poly-alanine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ...
Authors:Chen, L, Lin, Y.L, Peng, G, Li, F.
Deposit date:2013-12-11
Release date:2013-12-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for multifunctional roles of mammalian aminopeptidase N.
Proc.Natl.Acad.Sci.USA, 109, 2012
8GXE
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BU of 8gxe by Molmil
PTPN21 FERM PTP complex
Descriptor: CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 21
Authors:Chen, L, Zheng, Y.Y, Zhou, C.
Deposit date:2022-09-19
Release date:2023-09-27
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.
Sci Adv, 10, 2024
8GWH
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BU of 8gwh by Molmil
PTPN21 PTP domain C1108S mutant in complex with SRC pTyr530 peptide
Descriptor: SRC pTyr530 peptide, Tyrosine-protein phosphatase non-receptor type 21
Authors:Chen, L, Zheng, Y.Y, Zhou, C.
Deposit date:2022-09-17
Release date:2023-09-20
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.
Sci Adv, 10, 2024
8GVV
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BU of 8gvv by Molmil
PTPN21 PTP domain C1108S mutant
Descriptor: IODIDE ION, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 21
Authors:Chen, L, Zheng, Y.Y, Zhou, C.
Deposit date:2022-09-15
Release date:2023-09-20
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.
Sci Adv, 10, 2024
8GVL
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BU of 8gvl by Molmil
PTPN21 FERM
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Tyrosine-protein phosphatase non-receptor type 21
Authors:Chen, L, Zheng, Y.Y, Zhou, C.
Deposit date:2022-09-15
Release date:2023-09-20
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.
Sci Adv, 10, 2024

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數據於2024-05-15公開中

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