3TU1
 
 | | Exhaustive Fluorine Scanning towards Potent p53-MDM2 Antagonist | | 分子名称: | 2-(tert-butylamino)-1-(2-carboxy-6-chloro-1H-indol-3-yl)-1-[(3,4-difluorobenzyl)(formyl)amino]-2-oxoethylium, E3 ubiquitin-protein ligase Mdm2 | | 著者 | Wolf, S, Huang, Y, Koes, D, Popowicz, G.M, Camacho, C.J, Holak, T.A, Doemling, A. | | 登録日 | 2011-09-15 | | 公開日 | 2011-11-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.603 Å) | | 主引用文献 | Exhaustive Fluorine Scanning toward Potent p53-Mdm2 Antagonists.
Chemmedchem, 7, 2012
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8DQT
 | | Human PDK1 kinase domain in complex with Valsartan | | 分子名称: | (2~{S})-3-methyl-2-[pentanoyl-[[4-[2-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid, 3-phosphoinositide-dependent protein kinase 1, GLYCEROL | | 著者 | Gross, L.Z.F, Klinke, S, Biondi, R.M. | | 登録日 | 2022-07-19 | | 公開日 | 2023-06-21 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | | 主引用文献 | Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein.
Sci.Signal., 16, 2023
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5ACK
 | | Human PDK1 Kinase Domain in Complex with Allosteric Compound 7 Bound to the PIF-Pocket | | 分子名称: | 1-(4-CHLOROPHENETHYL)-2-(2-CHLOROPHENYL)-6-OXOPIPERIDINE-3-CARBOXYLIC ACID, 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Schulze, J.O, Kroon, E, Doemling, A, Biondi, R.M. | | 登録日 | 2015-08-17 | | 公開日 | 2015-10-21 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | | 主引用文献 | Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods.
Angew.Chem.Int.Ed.Engl., 54, 2015
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6RON
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6RSV
 | | Endothiapepsin in complex with 017 | | 分子名称: | 1~{H}-1,2,3,4-tetrazol-5-ylmethyldiazane, DIMETHYL SULFOXIDE, Endothiapepsin, ... | | 著者 | Magari, F, Heine, A, Klebe, G. | | 登録日 | 2019-05-22 | | 公開日 | 2020-07-08 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Endothiapepsin in complex with 017
To Be Published
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6SCV
 | | Endothiapepsin in complex with ligand 69 | | 分子名称: | Endothiapepsin, GLYCEROL, [(~{R})-cyclohexyl-[1-(2-phenylethyl)-1,2,3,4-tetrazol-5-yl]methyl]diazane | | 著者 | Magari, F, Heine, A, Klebe, G. | | 登録日 | 2019-07-25 | | 公開日 | 2020-08-26 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Endothiapepsin in complex with ligand 69
To Be Published
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6TGW
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