6T03
| Crystal structure of YTHDC1 with fragment 16 (DHU_DC1_017) | 分子名称: | 1,3-dihydroimidazole-2-thione, SULFATE ION, YTHDC1 | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | 登録日 | 2019-10-02 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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6SZ7
| Crystal structure of YTHDC1 with fragment 5 (DHU_DC1_066) | 分子名称: | 5,6,7,8-tetrahydro-4~{a}~{H}-quinazoline-2,4-dione, SULFATE ION, YTH domain-containing protein 1 | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | 登録日 | 2019-10-02 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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6SZR
| Crystal structure of YTHDC1 with fragment 9 (DHU_DC1_107) | 分子名称: | 6-[[methyl-(phenylmethyl)amino]methyl]-5~{H}-pyrimidine-2,4-dione, SULFATE ION, YTH domain-containing protein 1 | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | 登録日 | 2019-10-02 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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6SZX
| Crystal structure of YTHDC1 with fragment 11 (DHU_DC1_128) | 分子名称: | 6-[[cyclopropyl-(phenylmethyl)amino]methyl]-5~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1 | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | 登録日 | 2019-10-02 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | 主引用文献 | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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6T06
| Crystal structure of YTHDC1 with fragment 19 (DHU_DC1_045) | 分子名称: | 3-imidazolidin-2-yl-2~{H}-indazole, SULFATE ION, YTHDC1 | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | 登録日 | 2019-10-02 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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6T0C
| Crystal structure of YTHDC1 with fragment 26 (DHU_DC1_198) | 分子名称: | SULFATE ION, YTHDC1, ~{N}-methyl-2~{H}-indazole-3-carboxamide | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | 登録日 | 2019-10-02 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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6SZ2
| Crystal structure of YTHDC1 with fragment 3 (DHU_DC1_149) | 分子名称: | SULFATE ION, YTH domain-containing protein 1, ~{N}-methyl-1,6-naphthyridin-4-amine | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | 登録日 | 2019-10-01 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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6T08
| Crystal structure of YTHDC1 with fragment 21 (DHU_DC1_131) | 分子名称: | SULFATE ION, YTHDC1, ~{N}-(1~{H}-imidazol-2-yl)thiophene-2-sulfonamide | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | 登録日 | 2019-10-02 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
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5ETB
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5ETD
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5EVA
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5F3A
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5EV9
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5EWW
| Crystal structure of the human BRPF1 bromodomain in complex with SEED21 | 分子名称: | NITRATE ION, Peregrin, ~{N}-[(2~{R})-butan-2-yl]-1-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine | 著者 | Zhu, J, Wiedmer, L, Caflisch, A. | 登録日 | 2015-11-21 | 公開日 | 2016-11-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Crystal structure of the human BRPF1 bromodomain in complex with SEED21 To Be Published
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5EWH
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5EWV
| Crystal structure of the human BRPF1 bromodomain in complex with SEED20 | 分子名称: | 1,5-dimethyl-[1,2,4]triazolo[4,3-a]quinoline, NITRATE ION, Peregrin | 著者 | Zhu, J, Wiedmer, L, Caflisch, A. | 登録日 | 2015-11-21 | 公開日 | 2016-11-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Crystal structure of the human BRPF1 bromodomain in complex with SEED20 To Be Published
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5EWC
| Crystal structure of the human BRPF1 bromodomain in complex with SEED17 | 分子名称: | NITRATE ION, Peregrin, ethyl (2~{R})-2-methyl-3-oxidanylidene-2,4-dihydro-1~{H}-quinoxaline-6-carboxylate | 著者 | Zhu, J, Caflisch, A. | 登録日 | 2015-11-20 | 公開日 | 2016-05-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions. J.Med.Chem., 59, 2016
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5OR9
| Crystal Structure of BAZ2B bromodomain in complex with 1-methyl-cyclopentapyrazole compound 13 | 分子名称: | (2~{S})-1-(4-fluorophenyl)sulfonyl-~{N}-(2-methyl-5,6-dihydro-4~{H}-cyclopenta[c]pyrazol-3-yl)pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, Bromodomain adjacent to zinc finger domain protein 2B | 著者 | Lolli, G, Vedove, A.D, Marchand, J.-R, Caflisch, A. | 登録日 | 2017-08-15 | 公開日 | 2017-09-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of Inhibitors of Four Bromodomains by Fragment-Anchored Ligand Docking. J Chem Inf Model, 57, 2017
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5HCL
| Crystal Structure of the first bromodomain of BRD4 in complex with DMA | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N},~{N}-dimethylethanamide | 著者 | Dong, J, Weber, F.E, Caflisch, A. | 登録日 | 2016-01-04 | 公開日 | 2017-01-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment. Sci Rep, 7, 2017
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5C89
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5C85
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5C87
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5C7N
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5E3G
| Crystal structure of the human BRPF1 bromodomain in complex with SEED8 | 分子名称: | 2-thioxo-2,3,7,9-tetrahydro-1H-purine-6,8-dione, NITRATE ION, Peregrin | 著者 | Zhu, J, Caflisch, A. | 登録日 | 2015-10-02 | 公開日 | 2016-05-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions. J.Med.Chem., 59, 2016
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5E9Y
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