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2Q1H
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BU of 2q1h by Molmil
Ancestral Corticoid Receptor in Complex with Aldosterone
Descriptor: ALDOSTERONE, AncCR, GLYCEROL, ...
Authors:Ortlund, E.A, Bridgham, J.T, Redinbo, M.R, Thornton, J.W.
Deposit date:2007-05-24
Release date:2007-09-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of an ancient protein: evolution by conformational epistasis.
Science, 317, 2007
2Q3Y
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BU of 2q3y by Molmil
Ancestral Corticiod Receptor in Complex with DOC
Descriptor: Ancestral Corticiod Receptor, DESOXYCORTICOSTERONE, GLYCEROL, ...
Authors:Ortlund, E.A, Bridgham, J.T, Redinbo, M.R, Thornton, J.W.
Deposit date:2007-05-30
Release date:2007-09-04
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of an ancient protein: evolution by conformational epistasis
Science, 317, 2007
3GN8
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BU of 3gn8 by Molmil
X-ray Crystal Structure of AncGR2 in Complex with Dexamethasone
Descriptor: DEXAMETHASONE, Glucocorticoid receptor 2, Nuclear receptor coactivator 2
Authors:Ortlund, E.A.
Deposit date:2009-03-16
Release date:2009-09-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An epistatic ratchet constrains the direction of glucocorticoid receptor evolution
Nature, 461, 2009
4N1Y
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BU of 4n1y by Molmil
Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain
Descriptor: Estrogen receptor
Authors:Ortlund, E.O.
Deposit date:2013-10-04
Release date:2014-02-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.605 Å)
Cite:Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor.
PLoS Genet, 10, 2014
2Q1V
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BU of 2q1v by Molmil
Ancestral corticoid receptor in complex with cortisol
Descriptor: 17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE, AncCR, GLYCEROL
Authors:Ortlund, E.A, Redinbo, M.R.
Deposit date:2007-05-25
Release date:2007-09-04
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of an ancient protein: evolution by conformational epistasis.
Science, 317, 2007
4OND
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BU of 4ond by Molmil
Ancestral Steroid Receptor 2 DBD helix mutant - ERE DNA complex
Descriptor: 5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*GP*AP*GP*TP*GP*AP*CP*CP*TP*G)-3', 5'-D(*TP*CP*AP*GP*GP*TP*CP*AP*CP*TP*CP*TP*GP*AP*CP*CP*TP*G)-3', Ancestral SR2 Helix Mutant, ...
Authors:Ortlund, E.O, Murphy, M.N.
Deposit date:2014-01-28
Release date:2014-10-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.253 Å)
Cite:Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
Cell(Cambridge,Mass.), 159, 2014
4OV7
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BU of 4ov7 by Molmil
Ancestral Steroid Receptor 2 DBD helix mutant - SRE DNA complex
Descriptor: 5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3', 5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3', Ancestral Steroid Receptor 2 DBD helix mutant, ...
Authors:Ortlund, E.A.
Deposit date:2014-02-20
Release date:2014-10-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
Cell(Cambridge,Mass.), 159, 2014
4OOR
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BU of 4oor by Molmil
Ancestral Steroid Receptor 2 DNA binding domain in complex with a steroid response element
Descriptor: 5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3', 5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3', Ancestral Steroid Receptor 2 DNA binding domain, ...
Authors:Ortlund, E.O, Murphy, M.N.
Deposit date:2014-02-03
Release date:2014-10-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
Cell(Cambridge,Mass.), 159, 2014
4OLN
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BU of 4oln by Molmil
Ancestral Steroid Receptor 1 in complex with estrogen response element DNA
Descriptor: 5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*GP*AP*GP*TP*GP*AP*CP*CP*TP*GP*A)-3', 5'-D(*TP*CP*AP*GP*GP*TP*CP*AP*CP*TP*CP*TP*GP*AP*CP*CP*TP*GP*G)-3', AncSR1, ...
Authors:Ortlund, E.O, Murphy, M.N.
Deposit date:2014-01-24
Release date:2014-10-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
Cell(Cambridge,Mass.), 159, 2014

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