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2AY0
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BU of 2ay0 by Molmil
Structure of the Lys9Met mutant of the E. coli Proline Utilization A (PutA) DNA-binding domain.
Descriptor: Bifunctional putA protein, CHLORIDE ION
Authors:Larson, J.D, Schuermann, J.P, Zhou, Y, Jenkins, J.L, Becker, D.F, Tanner, J.J.
Deposit date:2005-09-06
Release date:2006-08-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of the DNA-binding domain of Escherichia coli proline utilization A flavoprotein and analysis of the role of Lys9 in DNA recognition.
Protein Sci., 15, 2006
1TJ1
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BU of 1tj1 by Molmil
Crystal structure of E. coli PutA proline dehydrogenase domain (residues 86-669) complexed with L-lactate
Descriptor: (2S)-2-HYDROXYPROPANOIC ACID, Bifunctional putA protein, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Tanner, J.J, Zhang, M, White, T.A, Schuermann, J.P, Baban, B.A, Becker, D.F.
Deposit date:2004-06-03
Release date:2004-10-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors
Biochemistry, 43, 2004
1TJ0
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BU of 1tj0 by Molmil
Crystal structure of E. coli PutA proline dehydrogenase domain (residues 86-669) co-crystallized with L-lactate
Descriptor: (2S)-2-HYDROXYPROPANOIC ACID, Bifunctional putA protein, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Tanner, J.J, Zhang, M, White, T.A, Schuermann, J.P, Baban, B.A, Becker, D.F.
Deposit date:2004-06-02
Release date:2004-10-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors
Biochemistry, 43, 2004
1TIW
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BU of 1tiw by Molmil
Crystal structure of E. coli PutA proline dehydrogenase domain (residues 86-669) complexed with L-Tetrahydro-2-furoic acid
Descriptor: Bifunctional putA protein, FLAVIN-ADENINE DINUCLEOTIDE, TETRAHYDROFURAN-2-CARBOXYLIC ACID
Authors:Tanner, J.J, Zhang, M, White, T.A, Schuermann, J.P, Baban, B.A, Becker, D.F.
Deposit date:2004-06-02
Release date:2004-10-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors
Biochemistry, 43, 2004
1TJ2
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BU of 1tj2 by Molmil
Crystal structure of E. coli PutA proline dehydrogenase domain (residues 86-669) complexed with acetate
Descriptor: ACETATE ION, Bifunctional putA protein, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Tanner, J.J, Zhang, M, White, T.A, Schuermann, J.P, Baban, B.A, Becker, D.F.
Deposit date:2004-06-03
Release date:2004-10-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors
Biochemistry, 43, 2004
2RBF
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BU of 2rbf by Molmil
Structure of the ribbon-helix-helix domain of Escherichia coli PutA (PutA52) complexed with operator DNA (O2)
Descriptor: Bifunctional protein putA, DNA (5'-D(*DTP*DT*DTP*DGP*DCP*DGP*DGP*DTP*DTP*DGP*DCP*DAP*DCP*DCP*DTP*DTP*DTP*DCP*DAP*DAP*DA)-3'), DNA (5'-D(*DTP*DTP*DTP*DGP*DAP*DAP*DAP*DGP*DGP*DTP*DGP*DCP*DAP*DAP*DCP*DCP*DGP*DCP*DAP*DAP*DA)-3')
Authors:Tanner, J.J.
Deposit date:2007-09-18
Release date:2008-07-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis of the transcriptional regulation of the proline utilization regulon by multifunctional PutA.
J.Mol.Biol., 381, 2008
2G37
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BU of 2g37 by Molmil
Structure of Thermus thermophilus L-proline dehydrogenase
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase
Authors:Tanner, J.J, White, T.A.
Deposit date:2006-02-17
Release date:2007-02-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and Kinetics of Monofunctional Proline Dehydrogenase from Thermus thermophilus.
J.Biol.Chem., 282, 2007
6ONO
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BU of 6ono by Molmil
Complex structure of WhiB1 and region 4 of SigA in C2221 space group
Descriptor: DI(HYDROXYETHYL)ETHER, IRON/SULFUR CLUSTER, RNA polymerase sigma factor SigA, ...
Authors:Wan, T, Li, S.R, Beltran, D.G, Schacht, A, Becker, D.C, Zhang, L.M.
Deposit date:2019-04-22
Release date:2019-11-27
Last modified:2020-01-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis of non-canonical transcriptional regulation by the sigma A-bound iron-sulfur protein WhiB1 in M. tuberculosis.
Nucleic Acids Res., 48, 2020
6ONU
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BU of 6onu by Molmil
Complex structure of WhiB1 and region 4 of SigA in P21 space group.
Descriptor: DI(HYDROXYETHYL)ETHER, IRON/SULFUR CLUSTER, RNA polymerase sigma factor SigA, ...
Authors:Wan, T, Li, S.R, Beltran, D.G, Schacht, A, Becker, D.C, Zhang, L.M.
Deposit date:2019-04-22
Release date:2019-11-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis of non-canonical transcriptional regulation by the sigma A-bound iron-sulfur protein WhiB1 in M. tuberculosis.
Nucleic Acids Res., 48, 2020
3V9I
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BU of 3v9i by Molmil
Crystal structure of human 1-pyrroline-5-carboxylate dehydrogenase mutant S352L
Descriptor: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Authors:Tanner, J.J, Singh, R.K.
Deposit date:2011-12-27
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Three-Dimensional Structural Basis of Type II Hyperprolinemia.
J.Mol.Biol., 420, 2012
3V9G
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BU of 3v9g by Molmil
Crystal structure of human 1-pyrroline-5-carboxylate dehydrogenase
Descriptor: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Authors:Tanner, J.J, Srivastava, D.
Deposit date:2011-12-27
Release date:2012-05-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Three-Dimensional Structural Basis of Type II Hyperprolinemia.
J.Mol.Biol., 420, 2012
3V9J
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BU of 3v9j by Molmil
Crystal structure of mouse 1-pyrroline-5-carboxylate dehydrogenase complexed with sulfate ion
Descriptor: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, GLYCEROL, ...
Authors:Tanner, J.J, Srivastava, D.
Deposit date:2011-12-27
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.299 Å)
Cite:The Three-Dimensional Structural Basis of Type II Hyperprolinemia.
J.Mol.Biol., 420, 2012
8DKG
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BU of 8dkg by Molmil
Structure of PYCR1 Thr171Met variant complexed with NADH
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Isoform 3 of Pyrroline-5-carboxylate reductase 1, mitochondrial, ...
Authors:Meeks, K.R, Tanner, J.J.
Deposit date:2022-07-05
Release date:2023-02-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Functional Impact of a Cancer-Related Variant in Human Delta 1 -Pyrroline-5-Carboxylate Reductase 1.
Acs Omega, 8, 2023
6XP0
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BU of 6xp0 by Molmil
Structure of human PYCR1 complexed with N-formyl L-proline
Descriptor: 1-formyl-L-proline, Pyrroline-5-carboxylate reductase 1, mitochondrial
Authors:Tanner, J.J, Christensen, E.M.
Deposit date:2020-07-07
Release date:2020-11-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1.
J.Biol.Chem., 295, 2020
6X9A
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BU of 6x9a by Molmil
Structure of proline utilization A with trans-4-hydroxy-D-proline bound in the L-glutamate-gamma-semialdehyde dehydrogenase active site
Descriptor: (4S)-4-hydroxy-D-proline, Bifunctional protein PutA, DI(HYDROXYETHYL)ETHER, ...
Authors:Tanner, J.J, Campbell, A.C.
Deposit date:2020-06-02
Release date:2020-12-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Structural analysis of prolines and hydroxyprolines binding to the l-glutamate-gamma-semialdehyde dehydrogenase active site of bifunctional proline utilization A.
Arch.Biochem.Biophys., 698, 2020
6XP3
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BU of 6xp3 by Molmil
Structure of human PYCR1 complexed with cyclopentanecarboxylic acid
Descriptor: Pyrroline-5-carboxylate reductase 1, mitochondrial, SULFATE ION, ...
Authors:Tanner, J.J, Bogner, A.N.
Deposit date:2020-07-07
Release date:2020-11-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1.
J.Biol.Chem., 295, 2020
6XP1
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BU of 6xp1 by Molmil
Structure of human PYCR1 complexed with L-thiazolidine-2-carboxylate
Descriptor: (2S)-1,3-thiazolidine-2-carboxylic acid, Pyrroline-5-carboxylate reductase 1, mitochondrial, ...
Authors:Tanner, J.J, Christensen, E.M.
Deposit date:2020-07-07
Release date:2020-11-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1.
J.Biol.Chem., 295, 2020
6X9D
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BU of 6x9d by Molmil
Structure of proline utilization A with trans-4-hydroxy-L-proline bound in the L-glutamate-gamma-semialdehyde dehydrogenase active site
Descriptor: 4-HYDROXYPROLINE, Bifunctional protein PutA, DI(HYDROXYETHYL)ETHER, ...
Authors:Tanner, J.J, Campbell, A.C.
Deposit date:2020-06-02
Release date:2020-12-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Structural analysis of prolines and hydroxyprolines binding to the l-glutamate-gamma-semialdehyde dehydrogenase active site of bifunctional proline utilization A.
Arch.Biochem.Biophys., 698, 2020
6XP2
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BU of 6xp2 by Molmil
Structure of human PYCR1 complexed with L-thiazolidine-4-carboxylate
Descriptor: Pyrroline-5-carboxylate reductase 1, mitochondrial, SULFATE ION, ...
Authors:Tanner, J.J, Christensen, E.M.
Deposit date:2020-07-07
Release date:2020-11-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1.
J.Biol.Chem., 295, 2020
5KF7
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BU of 5kf7 by Molmil
Structure of proline utilization A from Sinorhizobium meliloti complexed with L-tetrahydrofuroic acid and NAD+ in space group P3121
Descriptor: Bifunctional protein PutA, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ...
Authors:Tanner, J.J.
Deposit date:2016-06-12
Release date:2016-10-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of Proline Utilization A (PutA) Reveal the Fold and Functions of the Aldehyde Dehydrogenase Superfamily Domain of Unknown Function.
J.Biol.Chem., 291, 2016
5KF6
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BU of 5kf6 by Molmil
Structure of proline utilization A from Sinorhizobium meliloti complexed with L-tetrahydrofuroic acid and NAD+ in space group P21
Descriptor: Bifunctional protein PutA, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ...
Authors:Tanner, J.J.
Deposit date:2016-06-12
Release date:2016-10-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of Proline Utilization A (PutA) Reveal the Fold and Functions of the Aldehyde Dehydrogenase Superfamily Domain of Unknown Function.
J.Biol.Chem., 291, 2016
3V9H
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BU of 3v9h by Molmil
Crystal structure of human 1-pyrroline-5-carboxylate dehydrogenase mutant S352A
Descriptor: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, SULFATE ION
Authors:Tanner, J.J, Singh, R.K.
Deposit date:2011-12-27
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Three-Dimensional Structural Basis of Type II Hyperprolinemia.
J.Mol.Biol., 420, 2012
7NA0
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BU of 7na0 by Molmil
Structure of Geobacter sulfurreducens proline utilization A (PutA) variant A206W
Descriptor: 1,2-ETHANEDIOL, Bifunctional protein PutA, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Tanner, J.J, Korasick, D.A.
Deposit date:2021-06-19
Release date:2021-09-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Probing the function of a ligand-modulated dynamic tunnel in bifunctional proline utilization A (PutA).
Arch.Biochem.Biophys., 712, 2021
7MYB
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BU of 7myb by Molmil
Structure of proline utilization A with tetrahydrothiophene-2-carboxylate bound in the proline dehydrogenase active site
Descriptor: (2R)-thiolane-2-carboxylic acid, (2S)-thiolane-2-carboxylic acid, Bifunctional protein PutA, ...
Authors:Tanner, J.J, Campbell, A.C.
Deposit date:2021-05-20
Release date:2021-09-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Photoinduced Covalent Irreversible Inactivation of Proline Dehydrogenase by S-Heterocycles.
Acs Chem.Biol., 16, 2021
7MY9
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BU of 7my9 by Molmil
Structure of proline utilization A with 1,3-dithiolane-2-carboxylate bound in the proline dehydrogenase active site
Descriptor: 1,3-dithiolane-2-carboxylic acid, Bifunctional protein PutA, DI(HYDROXYETHYL)ETHER, ...
Authors:Tanner, J.J, Campbell, A.C.
Deposit date:2021-05-20
Release date:2021-09-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.628 Å)
Cite:Photoinduced Covalent Irreversible Inactivation of Proline Dehydrogenase by S-Heterocycles.
Acs Chem.Biol., 16, 2021

 

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