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BU of 2oc8 by Molmil

Structure of Hepatitis C Viral NS3 protease domain complexed with NS4A peptide and ketoamide SCH503034
分子名称:	BETA-MERCAPTOETHANOL, Hepatitis C virus, ZINC ION, ...
著者	Prongay, A.J, Guo, Z, Yao, N, Fischmann, T, Strickland, C, Myers, J, Weber, P.C, Malcolm, B, Beyer, B.M, Ingram, R, Pichardo, J, Hong, Z, Prosise, W.W, Ramanathan, L, Taremi, S.S, Yarosh-Tomaine, T, Zhang, R, Senior, M, Yang, R.S, Arasappan, A, Bennett, F, Bogen, S.L, Chen, K, Jao, E, Liu, Y.T, Lovey, R.G, Saksena, A.K, Venkatraman, S, Girijavallabhan, V, Njoroge, F.G, Madison, V.
登録日	2006-12-20
公開日	2007-07-31
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.66 Å)
主引用文献	Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization. J.Med.Chem., 50, 2007

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BU of 6h3r by Molmil

Crystal structure of Smad2 without exon -MH1 bound to the CAGAC site.
分子名称:	DNA (5'-D(PGPAPGPTPGPTPCPTPGPCPAPGPAPCPAPCPTPC)-3'), Mothers against decapentaplegic homolog, ZINC ION
著者	Kaczmarska, Z, Marquez, J.A, Macias, M.J.
登録日	2018-07-19
公開日	2019-09-18
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.75 Å)
主引用文献	Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-beta signaling Genes Dev., 2020

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BU of 3tyq by Molmil

SAR development and discovery of potent indole-based inhibitors of the hepatitis c virus NS5B polymerase
分子名称:	5-ethyl-1-(2-fluoro-5-nitrobenzyl)-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase
著者	Lesburg, C.A, Chen, K.X.
登録日	2011-09-26
公開日	2012-02-01
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	A Novel Class of Highly Potent Irreversible Hepatitis C Virus NS5B Polymerase Inhibitors. J.Med.Chem., 55, 2012

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BU of 3tyv by Molmil

SAR development and discovery of potent indole-based inhibitors of the hepatitis C virus NS5B polymerase
分子名称:	N-(cyclopropylsulfonyl)-1-(2,5-difluorobenzyl)-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide, PHOSPHATE ION, RNA-directed RNA polymerase
著者	Lesburg, C.A, Chen, K.X.
登録日	2011-09-26
公開日	2012-02-01
最終更新日	2024-03-06
実験手法	X-RAY DIFFRACTION (1.65 Å)
主引用文献	Structure-Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase. J.Med.Chem., 55, 2012

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BU of 5xgu by Molmil

Escherichia coli. RNase R
分子名称:	MAGNESIUM ION, Ribonuclease R
著者	Chu, L.Y, Hsieh, T.J, Yuan, H.S.
登録日	2017-04-17
公開日	2017-10-18
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (1.846 Å)
主引用文献	Structural insights into RNA unwinding and degradation by RNase R. Nucleic Acids Res., 45, 2017

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BU of 5zf6 by Molmil

Crystal structure of the dimeric human PNPase
分子名称:	Polyribonucleotide nucleotidyltransferase 1, mitochondrial
著者	Yuan, H.S, Golzarroshan, B.
登録日	2018-03-02
公開日	2018-08-22
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (2.796 Å)
主引用文献	Crystal structure of dimeric human PNPase reveals why disease-linked mutants suffer from low RNA import and degradation activities. Nucleic Acids Res., 46, 2018

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BU of 3lkh by Molmil

Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Characterization of Novel 6-Fluoro-N-[2-Hydroxy-1(S)-Benzamides
分子名称:	2-(2-{[(1S)-1-benzyl-2-hydroxyethyl]amino}-2-oxoethoxy)-N-butyl-6-fluoro-N-methylbenzamide, RNA-directed RNA polymerase
著者	Lesburg, C.A.
登録日	2010-01-27
公開日	2010-03-23
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides. Bioorg.Med.Chem.Lett., 20, 2010

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件を2024-05-15に公開中

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