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Structure of SARS-CoV-2 S protein in complex with Receptor Binding Domain antibody DH1047
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1047 heavy chain, ...
Authors:	Manne, K, Acharya, P.
Deposit date:	2021-01-12
Release date:	2021-01-27
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies. Cell, 184, 2021

7LCN

Structure of SARS-CoV-2 S protein in complex with N-terminal domain antibody DH1050.1
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1050.1 heavy chain, ...
Authors:	Manne, K, Acharya, P.
Deposit date:	2021-01-11
Release date:	2021-01-27
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.35 Å)
Cite:	In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies. Cell, 184, 2021

7LUA

Cryo-EM structure of DH898.1 Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH848 SOSIP gp120, ...
Authors:	Manne, K, Edwards, R.J, Acharya, P.
Deposit date:	2021-02-21
Release date:	2021-03-17
Last modified:	2021-06-09
Method:	ELECTRON MICROSCOPY (4.7 Å)
Cite:	Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021

7LU9

Cryo-EM structure of DH851.3 bound to HIV-1 CH505 Env
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Manne, K, Edwards, R.J, Acharya, P.
Deposit date:	2021-02-21
Release date:	2021-03-24
Last modified:	2021-06-09
Method:	ELECTRON MICROSCOPY (5.6 Å)
Cite:	Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021

7LWJ

Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 3-RBD down conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.24 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWV

UK (B.1.1.7) SARS-CoV-2 spike protein variant (S-GSAS-B.1.1.7) in the 1-RBD-up conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.12 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWQ

Mink Cluster 5-associated SARS-CoV-2 spike protein(S-GSAS-D614G-delFV) missing the S1 subunit and SD2 subdomain of one protomer
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.44 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWI

Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 3-RBD down conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.07 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWL

Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 3-RBD down conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (2.84 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWM

Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 1-RBD up conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (2.83 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWK

Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 3-RBD down conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (2.92 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWW

Triple mutant (K417N-E484K-N501Y) SARS-CoV-2 spike protein in the 1-RBD-up conformation (S-GSAS-D614G-K417N-E484K-N501Y)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWO

Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 1-RBD up conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (2.85 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWP

Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 2-RBD up conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.01 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LYM

South African (B.1.351) SARS-CoV-2 spike protein variant (S-GSAS-B.1.351) in the RBD-down conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-07
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.57 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWN

Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 1-RBD up conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (2.94 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWT

UK (B.1.1.7) SARS-CoV-2 spike protein variant (S-GSAS-B.1.1.7) in the 1-RBD-up conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.19 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7LWU

UK (B.1.1.7) SARS-CoV-2 spike protein variant (S-GSAS-B.1.1.7) in the 1-RBD-up conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Gobeil, S, Acharya, P.
Deposit date:	2021-03-01
Release date:	2021-03-31
Last modified:	2021-08-18
Method:	ELECTRON MICROSCOPY (3.22 Å)
Cite:	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity. Science, 373, 2021

7UB6

SARS-CoV-2 Omicron-BA.2 3-RBD down Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-Omicron-BA.2)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Stalls, V, Acharya, P.
Deposit date:	2022-03-14
Release date:	2022-04-20
Last modified:	2022-07-13
Method:	ELECTRON MICROSCOPY (3.52 Å)
Cite:	Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike. Cell Rep, 39, 2022

7UB0

SARS-CoV-2 Omicron-BA.2 3-RBD down Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-Omicron-BA.2)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Stalls, V, Acharya, P.
Deposit date:	2022-03-14
Release date:	2022-04-20
Last modified:	2022-07-13
Method:	ELECTRON MICROSCOPY (3.31 Å)
Cite:	Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike. Cell Rep, 39, 2022

7UB5

SARS-CoV-2 Omicron-BA.2 3-RBD down Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-Omicron-BA.2)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Stalls, V, Acharya, P.
Deposit date:	2022-03-14
Release date:	2022-04-20
Last modified:	2022-07-13
Method:	ELECTRON MICROSCOPY (3.35 Å)
Cite:	Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike. Cell Rep, 39, 2022

6UDA

Cryo-EM structure of CH235UCA bound to Man5-enriched CH505.N279K.G458Y.SOSIP.664
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CH235 UCA heavy chain Fab, CH235 UCA light chain Fab, ...
Authors:	Henderson, R, Acharya, P.
Deposit date:	2019-09-19
Release date:	2019-10-02
Last modified:	2020-07-29
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancester of CH235 lineage CD4bs broadly neutralizing antibodies. Plos Pathog., 15, 2019

6V8Z

VRC03 and 10-1074 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure
Descriptor:	10-1074 Fab Heavy Chain, 10-1074 Fab Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Henderson, R, Acharya, P.
Deposit date:	2019-12-12
Release date:	2020-02-05
Last modified:	2020-07-29
Method:	ELECTRON MICROSCOPY (2.9 Å)
Cite:	Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements. Nat Commun, 11, 2020

6V8X

VRC01 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ...
Authors:	Henderson, R, Acharya, P.
Deposit date:	2019-12-12
Release date:	2020-02-05
Last modified:	2020-07-29
Method:	ELECTRON MICROSCOPY (3 Å)
Cite:	Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements. Nat Commun, 11, 2020

7LL2

Cryo-EM structure of BG505 DS-SOSIP in complex with Glycan276-Dependent Broadly Neutralizing Antibody VRC33.01 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ...
Authors:	Manne, K, Acharya, P.
Deposit date:	2021-02-03
Release date:	2021-03-17
Last modified:	2021-11-17
Method:	ELECTRON MICROSCOPY (3.73 Å)
Cite:	Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies. Cell Rep, 37, 2021

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