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6MGV
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BU of 6mgv by Molmil
Structure of mechanically activated ion channel OSCA1.2 in nanodisc
分子名称: Calcium permeable stress-gated cation channel 1
著者Jojoa-Cruz, S, Saotome, K, Patapoutian, A, Ward, A.B.
登録日2018-09-15
公開日2018-11-14
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Cryo-EM structure of the mechanically activated ion channel OSCA1.2.
Elife, 7, 2018
6MLM
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BU of 6mlm by Molmil
H7 HA0 in complex with Fv from H7.5 IgG
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain Fv of H7.5 Fab, Hemagglutinin HA1 chain, ...
著者Pallesen, J, Turner, H.L, Ward, A.B.
登録日2018-09-27
公開日2019-02-20
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains.
PLoS Biol., 17, 2019
6MGW
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BU of 6mgw by Molmil
Structure of mechanically activated ion channel OSCA1.2 in LMNG
分子名称: Calcium permeable stress-gated cation channel 1
著者Jojoa-Cruz, S, Saotome, K, Patapoutian, A, Ward, A.B.
登録日2018-09-15
公開日2018-11-14
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structure of the mechanically activated ion channel OSCA1.2.
Elife, 7, 2018
8EQN
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BU of 8eqn by Molmil
BG505 UFO-E2p-L4P nanoparticle reconstructed by focused refinement with a mask around the nanoparticle core
分子名称: BG505 UFO-E2p-L4P
著者Antanasijevic, A, Zhang, Y.N, Zhu, J, Ward, A.B.
登録日2022-10-08
公開日2023-04-19
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimmers as HIV-1 vaccine candidates.
Nat Commun, 14, 2023
6NF4
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BU of 6nf4 by Molmil
Structure of zebrafish Otop1 in nanodiscs
分子名称: CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, Otopetrin1
著者Saotome, K, Lee, W.H, Liman, E.R, Ward, A.B.
登録日2018-12-18
公開日2019-06-05
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献Structures of the otopetrin proton channels Otop1 and Otop3.
Nat.Struct.Mol.Biol., 26, 2019
6NF6
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BU of 6nf6 by Molmil
Structure of chicken Otop3 in nanodiscs
分子名称: CHOLESTEROL HEMISUCCINATE, Otopetrin3
著者Saotome, K, Lee, W.H, Liman, E.R, Ward, A.B.
登録日2018-12-18
公開日2019-06-05
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Structures of the otopetrin proton channels Otop1 and Otop3.
Nat.Struct.Mol.Biol., 26, 2019
6NFC
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BU of 6nfc by Molmil
BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP42 fragmentantigen binding and base-binding RM20A3 fragment antigen binding
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG18-like precursor HMP42 fragment antigen binding heavy chain, ...
著者Ozorowski, G, Torres, J.L, Ward, A.B.
登録日2018-12-19
公開日2019-11-06
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.43 Å)
主引用文献A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses.
Science, 366, 2019
6NC3
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BU of 6nc3 by Molmil
AMC011 v4.2 SOSIP Env trimer in complex with fusion peptide targeting antibody VRC34 fragment antigen binding
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 Env AMC011 v4.2 SOSIP gp120, ...
著者Cottrell, C.A, Ozorowski, G, Torres, J.L, Ward, A.B.
登録日2018-12-10
公開日2019-06-19
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies.
Cell Host Microbe, 25, 2019
6NUS
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BU of 6nus by Molmil
SARS-Coronavirus NSP12 bound to NSP8 co-factor
分子名称: NSP12, NSP8, ZINC ION
著者Kirchdoerfer, R.N, Ward, A.B.
登録日2019-02-01
公開日2019-05-29
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors.
Nat Commun, 10, 2019
8F9M
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BU of 8f9m by Molmil
HIV Env germline targeting BG505_MD64_N332-GT5 SOSIP in complex with V3-glycan polyclonal Fab isolated from immunized wild type mice, and NHP monoclonal Fab RM20A3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505_MD64_N332-GT5 gp120, ...
著者Ozorowski, G, Ward, A.B.
登録日2022-11-23
公開日2024-05-15
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies
Science, 2024
8F92
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BU of 8f92 by Molmil
HIV Env BG505_MD39_B11 SOSIP boosting trimer in complex with B11_d77.7 mouse Fab and RM20A3 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B11_d77.7 Fab heavy chain, ...
著者Torres, J.L, Ozorowski, G, Ward, A.B.
登録日2022-11-23
公開日2024-05-15
実験手法ELECTRON MICROSCOPY (3.14 Å)
主引用文献mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies
Science, 2024
8F9G
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BU of 8f9g by Molmil
HIV Env germline targeting BG505_MD64_N332-GT5 SOSIP in complex with V3-glycan polyclonal Fab isolated from immunized BG18HCgl knock-in mice
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505_MD64_N332-GT5 gp120, ...
著者Ozorowski, G, Torres, J.L, Ward, A.B.
登録日2022-11-23
公開日2024-05-15
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies
Science, 2024
6NUR
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BU of 6nur by Molmil
SARS-Coronavirus NSP12 bound to NSP7 and NSP8 co-factors
分子名称: NSP12, NSP7, NSP8, ...
著者Kirchdoerfer, R.N, Ward, A.B.
登録日2019-02-01
公開日2019-05-29
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors.
Nat Commun, 10, 2019
6NC2
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BU of 6nc2 by Molmil
AMC011 v4.2 SOSIP Env trimer in complex with fusion peptide targeting antibody ACS202 fragment antigen binding
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMC011 v4.2 SOSIP gp120, ...
著者Cottrell, C.A, Ozorowski, G, Yuan, M, Copps, J, Wilson, I.A, Ward, A.B.
登録日2018-12-10
公開日2019-06-19
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (5.2 Å)
主引用文献Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies.
Cell Host Microbe, 25, 2019
6NF5
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BU of 6nf5 by Molmil
BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP1 fragmentantigen binding and base-binding RM20A3 fragment antigen binding
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG18-like precursor HMP1 fragment antigen binding heavy chain, ...
著者Ozorowski, G, Torres, J.L, Steichen, J.M, Schief, W.R, Ward, A.B.
登録日2018-12-18
公開日2019-11-06
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.71 Å)
主引用文献A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses.
Science, 366, 2019
6NIJ
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BU of 6nij by Molmil
PGT145 Fab in complex with full length AMC011 HIV-1 Env
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMC011 Glycoprotein 120, ...
著者Cottrell, C.A, Torrents de la Pena, A, Rantalainen, K, Torres, J.L, Ward, A.B.
登録日2018-12-29
公開日2019-07-31
最終更新日2023-04-05
実験手法ELECTRON MICROSCOPY (5.7 Å)
主引用文献Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics.
Plos Pathog., 15, 2019
6NUT
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BU of 6nut by Molmil
Ebola virus nucleoprotein - RNA complex
分子名称: Nucleoprotein, RNA (5'-R(P*AP*AP*AP*AP*AP*A)-3')
著者Kirchdoerfer, R.N, Ward, A.B.
登録日2019-02-01
公開日2019-05-01
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex.
Acta Crystallogr.,Sect.F, 75, 2019
6VO1
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BU of 6vo1 by Molmil
BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20J
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ...
著者Cottrell, C.A, Ward, A.B.
登録日2020-01-29
公開日2020-07-01
最終更新日2020-09-16
実験手法ELECTRON MICROSCOPY (3.88 Å)
主引用文献Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
Plos Pathog., 16, 2020
6VLR
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BU of 6vlr by Molmil
BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20E1 and PGT122 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIPv5.2 gp41, ...
著者Cottrell, C.A, Ward, A.B.
登録日2020-01-24
公開日2020-06-24
最終更新日2020-09-16
実験手法ELECTRON MICROSCOPY (4.42 Å)
主引用文献Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
Plos Pathog., 16, 2020
6VN0
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BU of 6vn0 by Molmil
BG505 SOSIP.v4.1 in complex with rhesus macaque Fab RM20F
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ...
著者Cottrell, C.A, Shin, M, Ward, A.B.
登録日2020-01-29
公開日2020-06-24
最終更新日2020-09-16
実験手法ELECTRON MICROSCOPY (4.25 Å)
主引用文献Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
Plos Pathog., 16, 2020
6X5C
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BU of 6x5c by Molmil
Asymmetric model of CD4-bound B41 HIV-1 Env SOSIP in complex with small molecule GO52
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ...
著者Ozorowski, G, Torres, J.L, Ward, A.B.
登録日2020-05-25
公開日2020-10-21
最終更新日2020-12-09
実験手法ELECTRON MICROSCOPY (4.04 Å)
主引用文献A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide.
Cell Rep, 33, 2020
6X5B
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BU of 6x5b by Molmil
Symmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with small molecule GO52
分子名称: 17b Fab heavy chain, 17b Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Ozorowski, G, Torres, J.L, Ward, A.B.
登録日2020-05-25
公開日2020-10-21
最終更新日2020-12-09
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide.
Cell Rep, 33, 2020
5ACO
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BU of 5aco by Molmil
Cryo-EM structure of PGT128 Fab in complex with BG505 SOSIP.664 Env trimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 ENVELOPE GLYCOPROTEIN, ...
著者Lee, J.H, Ward, A.B.
登録日2015-08-17
公開日2015-09-30
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.36 Å)
主引用文献Model Building and Refinement of a Natively Glycosylated HIV-1 Env Protein by High-Resolution Cryoelectron Microscopy.
Structure, 23, 2015
5AWN
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BU of 5awn by Molmil
Crystal structure of Human anti-HIV-1 broadly neutralizing antibody 3BC176 Fab
分子名称: Heavy chain of 3BC176 Fab, Light chain of 3BC176 Fab
著者Lee, J.H, Wilson, I.A, Ward, A.B.
登録日2015-07-06
公開日2015-11-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.887 Å)
主引用文献Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike.
Nat Commun, 6, 2015
5CCK
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BU of 5cck by Molmil
Crystal structure of Human anti-HIV-1 broadly neutralizing antibody 3BC315 Fab
分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Antibody 3BC315 Fab heavy chain, Antibody 3BC315 Fab light chain
著者Lee, J.H, Ward, A.B, Wilson, I.A.
登録日2015-07-02
公開日2015-10-07
最終更新日2019-12-11
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike.
Nat Commun, 6, 2015

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