8ADJ
| Poly(ADP-ribose) glycohydrolase (PARG) from Drosophila melanogaster in complex with PARG inhibitor PDD00017272 | 分子名称: | 1-[(2,5-dimethylpyrazol-3-yl)methyl]-N-(1-methylcyclopropyl)-3-[(2-methyl-1,3-thiazol-5-yl)methyl]-2,4-bis(oxidanylidene)quinazoline-6-sulfonamide, CHLORIDE ION, GLYCEROL, ... | 著者 | Ariza, A, Fontana, P. | 登録日 | 2022-07-08 | 公開日 | 2023-06-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.508 Å) | 主引用文献 | Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling. Nat Commun, 14, 2023
|
|
2MYS
| |
2H1Z
| |
6ZYO
| Structure of VIM-2 with 2-Mercaptomethyl-thiazolidine D-syn-1b | 分子名称: | (2~{S},4~{S})-2-ethoxycarbonyl-5,5-dimethyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase VIM-2, FORMIC ACID, ... | 著者 | Hinchliffe, P, Spencer, J. | 登録日 | 2020-08-02 | 公開日 | 2021-01-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-beta-lactamases. Chem Sci, 12, 2021
|
|
6ZYR
| Structure of IMP-1 with 2-Mercaptomethyl-thiazolidine L-anti-1b | 分子名称: | (2~{S},4~{R})-2-ethoxycarbonyl-5,5-dimethyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid, 1,2-ETHANEDIOL, ACETATE ION, ... | 著者 | Hinchliffe, P, Spencer, J. | 登録日 | 2020-08-02 | 公開日 | 2021-01-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-beta-lactamases. Chem Sci, 12, 2021
|
|
6ZYS
| Structure of IMP-1 with 2-Mercaptomethyl-thiazolidine D-syn-1b | 分子名称: | (2~{S},4~{S})-2-ethoxycarbonyl-5,5-dimethyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid, 1,2-ETHANEDIOL, Beta-lactamase IMP-1, ... | 著者 | Hinchliffe, P, Spencer, J. | 登録日 | 2020-08-02 | 公開日 | 2021-01-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.87000954 Å) | 主引用文献 | 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-beta-lactamases. Chem Sci, 12, 2021
|
|
6ZYN
| Structure of VIM-2 with 2-Mercaptomethyl-thiazolidine L-anti-1b | 分子名称: | (2~{S},4~{R})-2-ethoxycarbonyl-5,5-dimethyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase VIM-2, FORMIC ACID, ... | 著者 | Hinchliffe, P, Spencer, J. | 登録日 | 2020-08-02 | 公開日 | 2021-01-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.4000138 Å) | 主引用文献 | 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-beta-lactamases. Chem Sci, 12, 2021
|
|
6ZYQ
| Structure of NDM-1 with 2-Mercaptomethyl-thiazolidine D-syn-1b | 分子名称: | (2~{S},4~{S})-2-ethoxycarbonyl-5,5-dimethyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid, Metallo-beta-lactamase type 2, SULFATE ION, ... | 著者 | Hinchliffe, P, Spencer, J. | 登録日 | 2020-08-02 | 公開日 | 2021-01-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-beta-lactamases. Chem Sci, 12, 2021
|
|
6ZYP
| Structure of NDM-1 with 2-Mercaptomethyl-thiazolidine L-anti-1b | 分子名称: | (2~{S},4~{R})-2-ethoxycarbonyl-5,5-dimethyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid, Metallo-beta-lactamase type 2, SULFATE ION, ... | 著者 | Hinchliffe, P, Spencer, J. | 登録日 | 2020-08-02 | 公開日 | 2021-01-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-beta-lactamases. Chem Sci, 12, 2021
|
|
6FY5
| |
1AXH
| ATRACOTOXIN-HVI FROM HADRONYCHE VERSUTA (AUSTRALIAN FUNNEL-WEB SPIDER, NMR, 20 STRUCTURES | 分子名称: | ATRACOTOXIN-HVI | 著者 | Fletcher, J.I, O'Donoghue, S.I, Nilges, M, King, G.F. | 登録日 | 1996-11-04 | 公開日 | 1997-11-12 | 最終更新日 | 2021-02-03 | 実験手法 | SOLUTION NMR | 主引用文献 | The structure of a novel insecticidal neurotoxin, omega-atracotoxin-HV1, from the venom of an Australian funnel web spider. Nat.Struct.Biol., 4, 1997
|
|
1FV9
| |
1G9P
| |
1HVW
| |
1MMA
| X-RAY STRUCTURES OF THE MGADP, MGATPGAMMAS, AND MGAMPPNP COMPLEXES OF THE DICTYOSTELIUM DISCOIDEUM MYOSIN MOTOR DOMAIN | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MYOSIN | 著者 | Gulick, A.M, Bauer, C.B, Thoden, J.B, Rayment, I. | 登録日 | 1997-07-18 | 公開日 | 1997-12-03 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | X-ray structures of the MgADP, MgATPgammaS, and MgAMPPNP complexes of the Dictyostelium discoideum myosin motor domain. Biochemistry, 36, 1997
|
|
1MMG
| X-RAY STRUCTURES OF THE MGADP, MGATPGAMMAS, AND MGAMPPNP COMPLEXES OF THE DICTYOSTELIUM DISCOIDEUM MYOSIN MOTOR DOMAIN | 分子名称: | MAGNESIUM ION, MYOSIN, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | 著者 | Gulick, A.M, Bauer, C.B, Thoden, J.B, Rayment, I. | 登録日 | 1997-07-18 | 公開日 | 1997-12-03 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | X-ray structures of the MgADP, MgATPgammaS, and MgAMPPNP complexes of the Dictyostelium discoideum myosin motor domain. Biochemistry, 36, 1997
|
|
1MMN
| X-RAY STRUCTURES OF THE MGADP, MGATPGAMMAS, AND MGAMPPNP COMPLEXES OF THE DICTYOSTELIUM DISCOIDEUM MYOSIN MOTOR DOMAIN | 分子名称: | MAGNESIUM ION, MYOSIN, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Gulick, A.M, Bauer, C.B, Thoden, J.B, Rayment, I. | 登録日 | 1997-07-18 | 公開日 | 1997-12-03 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | X-ray structures of the MgADP, MgATPgammaS, and MgAMPPNP complexes of the Dictyostelium discoideum myosin motor domain. Biochemistry, 36, 1997
|
|
5VLR
| CRYSTAL STRUCTURE OF PI3K DELTA IN COMPLEX WITH A TRIFLUORO-ETHYL-PYRAZOL-PYROLOTRIAZINE INHIBITOR | 分子名称: | 4-acetyl-1-(3-{4-amino-5-[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}phenyl)-3,3-dimethylpiperazin-2-one, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 著者 | Sack, J.S. | 登録日 | 2017-04-26 | 公開日 | 2017-06-07 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase delta (PI3K delta ) Inhibitor for the Treatment of Immunological Disorders. J. Med. Chem., 60, 2017
|
|
3BZ9
| Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II | 分子名称: | (3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Allingham, J.S, Rayment, I. | 登録日 | 2008-01-17 | 公開日 | 2008-02-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design. Org.Biomol.Chem., 6, 2008
|
|
3BZ8
| Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II | 分子名称: | (3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Allingham, J.S, Rayment, I. | 登録日 | 2008-01-17 | 公開日 | 2008-02-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design. Org.Biomol.Chem., 6, 2008
|
|
3BZ7
| Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II | 分子名称: | (3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Allingham, J.S, Rayment, I. | 登録日 | 2008-01-17 | 公開日 | 2008-02-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design. Org.Biomol.Chem., 6, 2008
|
|
1I84
| CRYO-EM STRUCTURE OF THE HEAVY MEROMYOSIN SUBFRAGMENT OF CHICKEN GIZZARD SMOOTH MUSCLE MYOSIN WITH REGULATORY LIGHT CHAIN IN THE DEPHOSPHORYLATED STATE. ONLY C ALPHAS PROVIDED FOR REGULATORY LIGHT CHAIN. ONLY BACKBONE ATOMS PROVIDED FOR S2 FRAGMENT. | 分子名称: | SMOOTH MUSCLE MYOSIN ESSENTIAL LIGHT CHAIN, SMOOTH MUSCLE MYOSIN HEAVY CHAIN, SMOOTH MUSCLE MYOSIN REGULATORY LIGHT CHAIN | 著者 | Wendt, T, Taylor, D, Trybus, K.M, Taylor, K. | 登録日 | 2001-03-12 | 公開日 | 2001-03-28 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (20 Å) | 主引用文献 | Three-dimensional image reconstruction of dephosphorylated smooth muscle heavy meromyosin reveals asymmetry in the interaction between myosin heads and placement of subfragment 2. Proc.Natl.Acad.Sci.USA, 98, 2001
|
|
1D6B
| SOLUTION STRUCTURE OF DEFENSIN-LIKE PEPTIDE-2 (DLP-2) FROM PLATYPUS VENOM | 分子名称: | DEFENSIN-LIKE PEPTIDE-2 | 著者 | Torres, A.M, De Plater, G.M, Doverskog, M, C Birinyi-Strachan, L, Nicholson, G.M, Gallagher, C.H, Kuchel, P.W. | 登録日 | 1999-10-12 | 公開日 | 2000-06-21 | 最終更新日 | 2022-02-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Defensin-like peptide-2 from platypus venom: member of a class of peptides with a distinct structural fold. Biochem.J., 348, 2000
|
|
4PED
| Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthes | 分子名称: | Chaperone activity of bc1 complex-like, mitochondrial, SULFATE ION | 著者 | Bingman, C.A, Smith, R, Joshi, S, Stefely, J.A, Reidenbach, A.G, Ulbrich, A, Oruganty, O, Floyd, B.J, Jochem, A, Saunders, J.M, Johnson, I.E, Wrobel, R.L, Barber, G.E, Lee, D, Li, S, Kannan, N, Coon, J.J, Pagliarini, D.J, Mitochondrial Protein Partnership (MPP) | 登録日 | 2014-04-22 | 公開日 | 2014-11-19 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Mitochondrial ADCK3 Employs an Atypical Protein Kinase-like Fold to Enable Coenzyme Q Biosynthesis. Mol.Cell, 57, 2015
|
|