6ZYP
Structure of NDM-1 with 2-Mercaptomethyl-thiazolidine L-anti-1b
Summary for 6ZYP
Entry DOI | 10.2210/pdb6zyp/pdb |
Descriptor | Metallo-beta-lactamase type 2, ZINC ION, (2~{S},4~{R})-2-ethoxycarbonyl-5,5-dimethyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid, ... (5 entities in total) |
Functional Keywords | antibiotic resistance, lactamase, zinc, inhibitor, antimicrobial protein |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 2 |
Total formula weight | 52285.04 |
Authors | Hinchliffe, P.,Spencer, J. (deposition date: 2020-08-02, release date: 2021-01-20, Last modification date: 2024-01-31) |
Primary citation | Rossi, M.A.,Martinez, V.,Hinchliffe, P.,Mojica, M.F.,Castillo, V.,Moreno, D.M.,Smith, R.,Spellberg, B.,Drusano, G.L.,Banchio, C.,Bonomo, R.A.,Spencer, J.,Vila, A.J.,Mahler, G. 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-beta-lactamases. Chem Sci, 12:2898-2908, 2021 Cited by PubMed: 34164056DOI: 10.1039/d0sc05172a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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