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6WYJ
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BU of 6wyj by Molmil
Cryo-EM structure of the GltPh L152C-G321C mutant in the intermediate state
分子名称: ASPARTIC ACID, Glutamate transporter homolog
著者Font, J, Chen, I, Sobti, M, Stewart, A.G, Ryan, R.M.
登録日2020-05-13
公開日2021-02-17
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Glutamate transporters have a chloride channel with two hydrophobic gates.
Nature, 591, 2021
6WYL
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BU of 6wyl by Molmil
Cryo-EM structure of GltPh L152C-G351C mutant in the intermediate outward-facing state.
分子名称: ASPARTIC ACID, Glutamate transporter homolog
著者Font, J, Chen, I, Sobti, M, Stewart, A.G, Ryan, R.M.
登録日2020-05-13
公開日2021-02-17
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Glutamate transporters have a chloride channel with two hydrophobic gates.
Nature, 591, 2021
6WYK
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BU of 6wyk by Molmil
Cryo-EM structure of the GltPh L152C-G321C mutant in the intermediate chloride conducting state.
分子名称: ASPARTIC ACID, Glutamate transporter homolog
著者Font, J, Chen, I, Sobti, M, Stewart, A.G, Ryan, R.M.
登録日2020-05-13
公開日2021-02-17
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Glutamate transporters have a chloride channel with two hydrophobic gates.
Nature, 591, 2021
6BAU
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BU of 6bau by Molmil
Crystal Structure of GltPh R397C in complex with L-Cysteine
分子名称: CYSTEINE, Glutamate transporter homolog, SODIUM ION
著者Font, J, Scopelliti, A.J, Vandenberg, R.J, Boudker, O, Ryan, R.M.
登録日2017-10-15
公開日2018-01-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5.
Nat Commun, 9, 2018
6BAT
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BU of 6bat by Molmil
Crystal Structure of Wild-Type GltPh in complex with L-aspartate
分子名称: ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION
著者Font, J, Scopelliti, A.J, Vandenberg, R.J, Boudker, O, Ryan, R.M.
登録日2017-10-15
公開日2018-01-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5.
Nat Commun, 9, 2018
6BAV
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BU of 6bav by Molmil
Crystal Structure of GltPh R397C in complex with S-Benzyl-L-Cysteine
分子名称: BENZYLCYSTEINE, Glutamate transporter homolog, SODIUM ION
著者Font, J, Scopelliti, A.J, Vandenberg, R.J, Boudker, O, Ryan, R.M.
登録日2017-10-16
公開日2018-01-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5.
Nat Commun, 9, 2018
6BMI
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BU of 6bmi by Molmil
Crystal Structure of GltPh R397C in complex with L-Serine
分子名称: Glutamate transporter homolog, SERINE, SODIUM ION
著者Font, J, Scopelliti, A.J, Vandenberg, R.J, Boudker, O, Ryan, R.M.
登録日2017-11-14
公開日2018-01-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5.
Nat Commun, 9, 2018
6WZB
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BU of 6wzb by Molmil
Crystal structure of the GltPh V216C-G388C mutant cross-linked with divalent mercury
分子名称: ASPARTIC ACID, Glutamate transporter homolog, MERCURY (II) ION, ...
著者Chen, I, Font, J, Ryan, R.
登録日2020-05-13
公開日2021-02-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献Glutamate transporters have a chloride channel with two hydrophobic gates.
Nature, 591, 2021
6X01
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BU of 6x01 by Molmil
Crystal structure of the GltPh V216C-A391C mutant cross-linked in outward-facing state
分子名称: ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION
著者Chen, I, Font, J, Ryan, R.
登録日2020-05-15
公開日2021-02-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.65 Å)
主引用文献Glutamate transporters have a chloride channel with two hydrophobic gates.
Nature, 591, 2021
2NWW
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BU of 2nww by Molmil
Crystal structure of GltPh in complex with TBOA
分子名称: (3S)-3-(BENZYLOXY)-L-ASPARTIC ACID, 425aa long hypothetical proton glutamate symport protein
著者Gouaux, E, Boudker, O, Ryan, R, Yernool, D, Shimamoto, K.
登録日2006-11-16
公開日2007-02-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Nature, 445, 2007
2NWX
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BU of 2nwx by Molmil
Crystal structure of GltPh in complex with L-aspartate and sodium ions
分子名称: 425aa long hypothetical proton glutamate symport protein, ASPARTIC ACID, PALMITIC ACID, ...
著者Gouaux, E, Boudker, O, Ryan, R, Yernool, D, Shimamoto, K.
登録日2006-11-16
公開日2007-02-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.29 Å)
主引用文献Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Nature, 445, 2007
2NWL
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BU of 2nwl by Molmil
Crystal structure of GltPh in complex with L-Asp
分子名称: ASPARTIC ACID, PALMITIC ACID, glutamate symport protein
著者Gouaux, E, Boudker, O, Ryan, R, Yernool, D, Shimamoto, K.
登録日2006-11-15
公開日2007-02-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Nature, 445, 2007
7LQK
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BU of 7lqk by Molmil
Crystal structure of the R375A mutant of LeuT
分子名称: ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ...
著者Font, J, Aguilar, J, Galli, A, Ryan, R.
登録日2021-02-13
公開日2021-05-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia.
Elife, 10, 2021
7LQJ
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BU of 7lqj by Molmil
Crystal structure of LeuT bound to L-Alanine
分子名称: ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ...
著者Font, J, Aguilar, J, Galli, A, Ryan, R.
登録日2021-02-13
公開日2021-05-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.144 Å)
主引用文献Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia.
Elife, 10, 2021
7LQL
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BU of 7lql by Molmil
Crystal structure of the R375D mutant of LeuT
分子名称: ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ...
著者Font, J, Aguilar, J, Galli, A, Ryan, R.
登録日2021-02-13
公開日2021-05-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia.
Elife, 10, 2021
8SC3
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BU of 8sc3 by Molmil
Human OCT1 bound to fenoterol in inward-open conformation
分子名称: Fenoterol, Solute carrier family 22 member 1
著者Zeng, Y.C, Sobti, M, Stewart, A.G.
登録日2023-04-04
公開日2023-10-18
最終更新日2023-10-25
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8SC4
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BU of 8sc4 by Molmil
Human OCT1 bound to metformin in inward-open conformation
分子名称: Metformin, Solute carrier family 22 member 1
著者Zeng, Y.C, Sobti, M, Stewart, A.G.
登録日2023-04-04
公開日2023-10-18
最終更新日2023-10-25
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8SC1
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BU of 8sc1 by Molmil
Human OCT1 (Apo) in inward-open conformation
分子名称: Solute carrier family 22 member 1
著者Zeng, Y.C, Sobti, M, Stewart, A.G.
登録日2023-04-04
公開日2023-10-18
最終更新日2023-10-25
実験手法ELECTRON MICROSCOPY (2.92 Å)
主引用文献Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8SC2
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BU of 8sc2 by Molmil
Human OCT1 bound to diltiazem in inward-open conformation
分子名称: Diltiazem, Solute carrier family 22 member 1
著者Zeng, Y.C, Sobti, M, Stewart, A.G.
登録日2023-04-04
公開日2023-10-18
最終更新日2023-10-25
実験手法ELECTRON MICROSCOPY (3.36 Å)
主引用文献Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023
8SC6
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BU of 8sc6 by Molmil
Human OCT1 bound to thiamine in inward-open conformation
分子名称: 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Solute carrier family 22 member 1
著者Zeng, Y.C, Sobti, M, Stewart, A.G.
登録日2023-04-04
公開日2023-10-18
最終更新日2023-10-25
実験手法ELECTRON MICROSCOPY (3.13 Å)
主引用文献Structural basis of promiscuous substrate transport by Organic Cation Transporter 1.
Nat Commun, 14, 2023

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件を2024-05-01に公開中

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