8PMA
| Crystal structure of human V30M transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder) | Descriptor: | (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin | Authors: | Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D. | Deposit date: | 2023-06-28 | Release date: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties. Eur.J.Med.Chem., 261, 2023
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1AYE
| HUMAN PROCARBOXYPEPTIDASE A2 | Descriptor: | PROCARBOXYPEPTIDASE A2, ZINC ION | Authors: | Garcia-Saez, I, Reverte, D, Vendrell, J, Aviles, F.X, Coll, M. | Deposit date: | 1997-11-03 | Release date: | 1999-01-13 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The three-dimensional structure of human procarboxypeptidase A2. Deciphering the basis of the inhibition, activation and intrinsic activity of the zymogen. EMBO J., 16, 1997
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4E4J
| Crystal structure of arginine deiminase from Mycoplasma penetrans | Descriptor: | Arginine deiminase, CHLORIDE ION | Authors: | Benach, J, Gallego, P, Planell, R, Querol, E, Perez Pons, J.A, Reverter, D. | Deposit date: | 2012-03-13 | Release date: | 2012-10-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Characterization of the Enzymes Composing the Arginine Deiminase Pathway in Mycoplasma penetrans. Plos One, 7, 2012
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6TXW
| V30G Transthyretin structure in complex with Tolcalpone | Descriptor: | Tolcapone, Transthyretin | Authors: | Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S. | Deposit date: | 2020-01-14 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.153 Å) | Cite: | Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis. Febs J., 288, 2021
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6TXV
| A25T Transthyretin structure in complex with Tolcalpone | Descriptor: | Tolcapone, Transthyretin | Authors: | Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S. | Deposit date: | 2020-01-14 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis. Febs J., 288, 2021
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5FWB
| Human Spectrin SH3 domain D48G, E7F, K60F | Descriptor: | SPECTRIN ALPHA CHAIN, NON-ERYTHROCYTIC 1 | Authors: | Gallego, P, Navarro, S, Ventura, S, Reverter, D. | Deposit date: | 2016-02-12 | Release date: | 2016-12-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Human Spectrin SH3 Domain D48G, E7F, K60F To be Published
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5MRV
| Crystal structure of human carboxypeptidase O in complex with NvCI | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Carboxypeptidase O, Metallocarboxypeptidase inhibitor, ... | Authors: | Garcia-Pardo, J, Garcia-Guerrero, M.C, Fernandez-Alvarez, R, Lyons, P, Aviles, F.X, Lorenzo, J, Reverter, D. | Deposit date: | 2016-12-27 | Release date: | 2018-01-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.854 Å) | Cite: | Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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3UIN
| Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2 | Descriptor: | E3 SUMO-protein ligase RanBP2, Ran GTPase-activating protein 1, SUMO-conjugating enzyme UBC9, ... | Authors: | Gareau, J.R, Reverter, D, Lima, C.D. | Deposit date: | 2011-11-05 | Release date: | 2011-12-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.597 Å) | Cite: | Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2. J.Biol.Chem., 287, 2012
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3UIP
| Complex between human RanGAP1-SUMO1, UBC9 and the IR1 domain from RanBP2 containing IR2 Motif II | Descriptor: | E3 SUMO-protein ligase RanBP2, Ran GTPase-activating protein 1, SUMO-conjugating enzyme UBC9, ... | Authors: | Gareau, J.R, Reverter, D, Lima, C.D. | Deposit date: | 2011-11-05 | Release date: | 2011-12-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.293 Å) | Cite: | Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2. J.Biol.Chem., 287, 2012
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3UIO
| Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2 containing IR2 Motif II | Descriptor: | E3 SUMO-protein ligase RanBP2, Ran GTPase-activating protein 1, SUMO-conjugating enzyme UBC9, ... | Authors: | Gareau, J.R, Reverter, D, Lima, C.D. | Deposit date: | 2011-11-05 | Release date: | 2011-12-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.602 Å) | Cite: | Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2. J.Biol.Chem., 287, 2012
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4BWR
| Crystal structure of c5321: a protective antigen present in uropathogenic Escherichia coli strains displaying an SLR fold | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Urosev, D, Ferrer-Navarro, M, Pastorello, I, Cartocci, E, Costenaro, L, Zhulenkovs, D, Marechal, J.-D, Leonchiks, A, Reverter, D, Serino, L, Soriani, M, Daura, X. | Deposit date: | 2013-07-04 | Release date: | 2013-07-24 | Last modified: | 2013-10-23 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Crystal Structure of C5321: A Protective Antigen Present in Uropathogenic Escherichia Coli Strains Displaying an Slr Fold. Bmc Struct.Biol., 13, 2013
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6FWW
| GFP/KKK. A redesigned GFP with improved solubility | Descriptor: | Green fluorescent protein | Authors: | Varejao, N, Lascorz, J, Gil-Garcia, M, Diaz-Caballero, M, Navarro, S, Ventura, S, Reverter, D. | Deposit date: | 2018-03-07 | Release date: | 2018-08-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.131 Å) | Cite: | Combining Structural Aggregation Propensity and Stability Predictions To Redesign Protein Solubility. Mol. Pharm., 15, 2018
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6FXU
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6FZL
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6FWD
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6GUM
| Structure of the A.thaliana E1 UFD domain in complex with E2 | Descriptor: | GLYCEROL, SAE2, SUMO-conjugating enzyme SCE1 | Authors: | Liu, B, Lois, L.M, Reverter, D. | Deposit date: | 2018-06-19 | Release date: | 2019-07-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.792 Å) | Cite: | Structural insights into SUMO E1-E2 interactions in Arabidopsis uncovers a distinctive platform for securing SUMO conjugation specificity across evolution. Biochem.J., 476, 2019
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6GV3
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3ZKF
| Structure of LC8 in complex with Nek9 phosphopeptide | Descriptor: | DYNEIN LIGHT CHAIN 1, CYTOPLASMIC, NEK9 PROTEIN | Authors: | Gallego, P, Velazquez-Campoy, A, Regue, L, Roig, J, Reverter, D. | Deposit date: | 2013-01-22 | Release date: | 2013-03-20 | Last modified: | 2013-05-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Analysis of the Regulation of the Dynll/Lc8 Binding to Nek9 by Phosphorylation J.Biol.Chem., 288, 2013
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3ZO5
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4A38
| METALLO-CARBOXYPEPTIDASE FROM PSEUDOMONAS AUREGINOSA IN COMPLEX WITH L-BENZYLSUCCINIC ACID | Descriptor: | L-BENZYLSUCCINIC ACID, METALLO-CARBOXYPEPTIDASE, ZINC ION | Authors: | Otero, A, Rodriguez de la Vega, M, Tanco, S.M, Lorenzo, J, Aviles, F.X, Reverter, D. | Deposit date: | 2011-09-30 | Release date: | 2012-05-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Novel Structure of a Cytosolic M14 Metallocarboxypeptidase (Ccp) from Pseudomonas Aeruginosa: A Model for Mammalian Ccps. Faseb J., 26, 2012
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4ANF
| Structure of the ornithine carbamoyltransferase from Mycoplasma penetrans with a P23 Space group | Descriptor: | ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC | Authors: | Gallego, P, Benach, J, Planell, R, Querol, E, Perez-Pons, J.A, Reverter, D. | Deposit date: | 2012-03-16 | Release date: | 2012-03-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Characterization of the Enzymes Composing the Arginine Deiminase Pathway in Mycoplasma Penetrans. Plos One, 7, 2012
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4A94
| Structure of the carboxypeptidase inhibitor from Nerita versicolor in complex with human CPA4 | Descriptor: | CARBOXYPEPTIDASE A4, CARBOXYPEPTIDASE INHIBITOR, NITRATE ION, ... | Authors: | Covaleda, G, Alonso, M, Chavez, M.A, Aviles, F.X, Reverter, D. | Deposit date: | 2011-11-23 | Release date: | 2011-12-28 | Last modified: | 2012-03-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structure of a Novel Metallo-Carboxypeptidase Inhibitor from the Marine Mollusk Nerita Versicolor in Complex with Human Carboxypeptidase A4. J.Biol.Chem., 287, 2012
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4A39
| Metallo-carboxypeptidase from Pseudomonas Aeruginosa in complex with (2-guanidinoethylmercapto)succinic acid | Descriptor: | (2-GUANIDINOETHYLMERCAPTO)SUCCINIC ACID, METALLO-CARBOXYPEPTIDASE, ZINC ION | Authors: | Otero, A, Rodriguez de la Vega, M, Tanco, S.M, Lorenzo, J, Aviles, F.X, Reverter, D. | Deposit date: | 2011-09-30 | Release date: | 2012-05-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The Novel Structure of a Cytosolic M14 Metallocarboxypeptidase (Ccp) from Pseudomonas Aeruginosa: A Model for Mammalian Ccps. Faseb J., 26, 2012
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4AMU
| Structure of ornithine carbamoyltransferase from Mycoplasma penetrans with a P321 space group | Descriptor: | ORNITHINE CARBAMOYLTRANSFERASE, CATABOLIC | Authors: | Gallego, P, Benach, J, Planell, R, Querol, E, Perez-Pons, J.A, Reverter, D. | Deposit date: | 2012-03-13 | Release date: | 2012-03-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Characterization of the Enzymes Composing the Arginine Deiminase Pathway in Mycoplasma Penetrans. Plos One, 7, 2012
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4BD9
| Structure of the complex between SmCI and human carboxypeptidase A4 | Descriptor: | CARBOXYPEPTIDASE A4, CARBOXYPEPTIDASE INHIBITOR SMCI, ZINC ION | Authors: | Alonso-del-Ribero, M, Reytor, M.L, Trejo, S.A, Chavez, M.A, Aviles, F.X, Reverter, D. | Deposit date: | 2012-10-05 | Release date: | 2013-07-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A Noncanonical Mechanism of Carboxypeptidase Inhibition Revealed by the Crystal Structure of the Tri-Kunitz Smci in Complex with Human Cpa4. Structure, 21, 2013
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