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2PVR
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BU of 2pvr by Molmil
Crystal structure of the catalytic subunit of protein kinase CK2 (C-terminal deletion mutant 1-335) in complex with two sulfate ions
分子名称: Casein kinase II subunit alpha, catalytic subunit, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Niefind, K, Yde, C.W, Ermakova, I, Issinger, O.-G.
登録日2007-05-10
公開日2007-06-26
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.605 Å)
主引用文献Evolved to Be Active: Sulfate Ions Define Substrate Recognition Sites of CK2alpha and Emphasise its Exceptional Role within the CMGC Family of Eukaryotic Protein Kinases
J.Mol.Biol., 370, 2007
1NXQ
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BU of 1nxq by Molmil
Crystal Structure of R-alcohol dehydrogenase (RADH) (apoenyzme) from Lactobacillus brevis
分子名称: MAGNESIUM ION, R-alcohol dehydrogenase
著者Niefind, K, Muller, J, Riebel, B, Hummel, W, Schomburg, D.
登録日2003-02-11
公開日2003-04-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献The crystal structure of R-specific alcohol dehydrogenase from Lactobacillus brevis suggests the structural basis of its metal dependency
J.Mol.Biol., 327, 2003
1DAY
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BU of 1day by Molmil
CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-GMPPNP
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, PROTEIN KINASE CK2
著者Niefind, K, Puetter, M, Guerra, B, Issinger, O.G, Schomburg, D.
登録日1999-11-01
公開日2000-05-03
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献GTP plus water mimic ATP in the active site of protein kinase CK2.
Nat.Struct.Biol., 6, 1999
1DAW
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BU of 1daw by Molmil
CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-AMPPNP
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PROTEIN KINASE CK2
著者Niefind, K, Puetter, M, Guerra, B, Issinger, O.G, Schomburg, D.
登録日1999-11-01
公開日2000-05-03
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献GTP plus water mimic ATP in the active site of protein kinase CK2.
Nat.Struct.Biol., 6, 1999
1HYH
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BU of 1hyh by Molmil
CRYSTAL STRUCTURE OF L-2-HYDROXYISOCAPROATE DEHYDROGENASE FROM LACTOBACILLUS CONFUSUS AT 2.2 ANGSTROMS RESOLUTION-AN EXAMPLE OF STRONG ASYMMETRY BETWEEN SUBUNITS
分子名称: L-2-HYDROXYISOCAPROATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION
著者Niefind, K, Hecht, H.-J, Schomburg, D.
登録日1995-06-05
公開日1995-10-15
最終更新日2023-07-26
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of L-2-hydroxyisocaproate dehydrogenase from Lactobacillus confusus at 2.2 A resolution. An example of strong asymmetry between subunits.
J.Mol.Biol., 251, 1995
1JWH
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BU of 1jwh by Molmil
Crystal Structure of Human Protein Kinase CK2 Holoenzyme
分子名称: Casein kinase II beta chain, Casein kinase II, alpha chain, ...
著者Niefind, K, Guerra, B, Ermakowa, I, Issinger, O.G.
登録日2001-09-04
公開日2002-03-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme.
EMBO J., 20, 2001
5M44
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BU of 5m44 by Molmil
Complex structure of human protein kinase CK2 catalytic subunit with a thieno[2,3-d]pyrimidin inhibitor crystallized under high-salt conditions
分子名称: 3-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylpropanoic acid, CHLORIDE ION, Casein kinase II subunit alpha
著者Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O.
登録日2016-10-18
公開日2017-01-18
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
5M4U
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BU of 5m4u by Molmil
ORTHORHOMBIC COMPLEX STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA') WITH THE INHIBITOR 4'-CARBOXY-6,8-CHLORO- FLAVONOL (FLC21)
分子名称: 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid, ACETATE ION, CHLORIDE ION, ...
著者Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O.
登録日2016-10-19
公開日2017-01-18
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.195 Å)
主引用文献Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
5M4F
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BU of 5m4f by Molmil
Complex structure of human protein kinase CK2 catalytic subunit with the inhibitor 4'-carboxy-6,8-chloro-flavonol (FLC21) crystallized under low-salt conditions
分子名称: 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid, CHLORIDE ION, Casein kinase II subunit alpha, ...
著者Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O.
登録日2016-10-18
公開日2017-01-18
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.519 Å)
主引用文献Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
5M4I
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BU of 5m4i by Molmil
Complex structure of human protein kinase CK2 catalytic subunit with the inhibitor 4'-carboxy-6,8-chloro-flavonol (FLC21) crystallized under high-salt conditions
分子名称: 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid, CHLORIDE ION, Casein kinase II subunit alpha
著者Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O.
登録日2016-10-18
公開日2017-01-18
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.218 Å)
主引用文献Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
5M4C
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BU of 5m4c by Molmil
Complex structure of human protein kinase CK2 catalytic subunit with a thieno[2,3-d]pyrimidin inhibitor crystallized under low-salt conditions
分子名称: 3-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylpropanoic acid, CHLORIDE ION, Casein kinase II subunit alpha, ...
著者Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O.
登録日2016-10-18
公開日2017-01-18
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.935 Å)
主引用文献Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
5M56
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BU of 5m56 by Molmil
Monoclinic complex structure of human protein kinase CK2 catalytic subunit (isoform CK2alpha') with the inhibitor 4'-carboxy-6,8-chloro-flavonol (FLC21)
分子名称: 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid, CHLORIDE ION, Casein kinase II subunit alpha', ...
著者Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O.
登録日2016-10-20
公開日2017-01-18
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.237 Å)
主引用文献Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor.
Pharmaceuticals, 10, 2017
3U87
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BU of 3u87 by Molmil
Structure of a chimeric construct of human CK2alpha and human CK2alpha' in complex with a non-hydrolysable ATP-analogue
分子名称: CHLORIDE ION, Casein kinase II subunit alpha, GLYCEROL, ...
著者Niefind, K, Raaf, J, Issinger, O.-G, Olsen, B.
登録日2011-10-16
公開日2012-05-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Low-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing bias.
Acta Crystallogr.,Sect.D, 68, 2012
1LR4
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BU of 1lr4 by Molmil
Room Temperature Crystal Structure of the Apo-form of the catalytic subunit of protein kinase CK2 from Zea mays
分子名称: BENZAMIDINE, Protein kinase CK2
著者Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D.
登録日2002-05-14
公開日2002-05-29
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
3FWQ
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BU of 3fwq by Molmil
Inactive conformation of human protein kinase CK2 catalytic subunit
分子名称: CHLORIDE ION, Casein kinase II subunit alpha, GLYCEROL, ...
著者Niefind, K, Raaf, J, Issinger, O.G.
登録日2009-01-19
公開日2009-02-17
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献First inactive conformation of CK2 alpha, the catalytic subunit of protein kinase CK2
J.Mol.Biol., 386, 2009
4UB7
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BU of 4ub7 by Molmil
High-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26) showing an extreme distortion of the ATP-binding loop combined with a pi-halogen bond
分子名称: 4-(6,8-dibromo-3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid, CHLORIDE ION, Casein kinase II subunit alpha
著者Niefind, K, Bischoff, N, Guerra, B, Golub, A, Issinger, O.-G.
登録日2014-08-12
公開日2015-07-01
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2 alpha Complex Structures.
Acs Chem.Biol., 10, 2015
4UBA
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BU of 4uba by Molmil
Low-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26)
分子名称: 4-(6,8-dibromo-3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid, Casein kinase II subunit alpha
著者Niefind, K, Bischoff, N, Guerra, B, Golub, A, Issinger, O.-G.
登録日2014-08-12
公開日2015-07-01
実験手法X-RAY DIFFRACTION (2.995 Å)
主引用文献A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2 alpha Complex Structures.
Acs Chem.Biol., 10, 2015
7B8I
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BU of 7b8i by Molmil
Tetragonal structure of human protein kinase CK2 catalytic subunit in complex with a heparin oligo saccharide
分子名称: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, Casein kinase II subunit alpha, GLYCEROL, ...
著者Niefind, K, Schnitzler, A.
登録日2020-12-12
公開日2021-02-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structural basis for the design of bisubstrate inhibitors of protein kinase CK2 provided by complex structures with the substrate-competitive inhibitor heparin.
Eur.J.Med.Chem., 214, 2021
1LP4
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BU of 1lp4 by Molmil
Crystal structure of a binary complex of the catalytic subunit of protein kinase CK2 with Mg-AMPPNP
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Protein kinase CK2
著者Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D.
登録日2002-05-07
公開日2002-05-29
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
1LPU
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BU of 1lpu by Molmil
Low Temperature Crystal Structure of the Apo-form of the catalytic subunit of protein kinase CK2 from Zea mays
分子名称: BENZAMIDINE, Protein kinase CK2
著者Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D.
登録日2002-05-08
公開日2002-05-29
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
6Q6Z
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BU of 6q6z by Molmil
Structure of the plant immune signaling node EDS1 (enhanced disease susceptibility 1) in complex with nanobody ENB21
分子名称: EDS1-SPECIFIC NANOBODY, Protein EDS1L
著者Niefind, K, Voss, M, Toelzer, C.
登録日2018-12-12
公開日2019-10-02
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.476 Å)
主引用文献Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation.
J.Struct.Biol., 208, 2019
5D7B
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BU of 5d7b by Molmil
Trigonal Crystal Structure of an acetylester hydrolase from Corynebacterium glutamicum
分子名称: GLYCEROL, Homoserine O-acetyltransferase
著者Niefind, K, Toelzer, C, Pal, S, Altenbuchner, J, Watzlawick, H.
登録日2015-08-13
公開日2015-12-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献A novel esterase subfamily with alpha / beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to l-homoserine O-acetyl transferases.
Febs Lett., 590, 2016
5D6O
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BU of 5d6o by Molmil
Orthorhombic Crystal Structure of an acetylester hydrolase from Corynebacterium glutamicum
分子名称: CHLORIDE ION, GLYCEROL, Homoserine O-acetyltransferase, ...
著者Niefind, K, Toelzer, C, Altenbuchner, J, Watzlawick, H.
登録日2015-08-12
公開日2015-12-09
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A novel esterase subfamily with alpha / beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to l-homoserine O-acetyl transferases.
Febs Lett., 590, 2016
3JUH
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BU of 3juh by Molmil
Crystal structure of a mutant of human protein kinase CK2alpha with altered cosubstrate specificity
分子名称: CHLORIDE ION, Casein kinase II subunit alpha, GLYCEROL, ...
著者Niefind, K, Issinger, O.-G.
登録日2009-09-15
公開日2009-10-20
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate
J.Mol.Biol., 347, 2005
6SPX
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BU of 6spx by Molmil
Structure of protein kinase CK2 catalytic subunit in complex with the CK2beta-competitive bisubstrate inhibitor ARC1502
分子名称: 8-[4,5,6,7-tetrakis(bromanyl)benzimidazol-1-yl]octanoic acid, ARC1502, Casein kinase II subunit alpha
著者Niefind, K, Schnitzler, A.
登録日2019-09-03
公開日2020-01-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.994 Å)
主引用文献Unexpected CK2 beta-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2.
Bioorg.Chem., 96, 2020

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