6SPX
Structure of protein kinase CK2 catalytic subunit in complex with the CK2beta-competitive bisubstrate inhibitor ARC1502
Summary for 6SPX
Entry DOI | 10.2210/pdb6spx/pdb |
Related | 6SPW |
Descriptor | Casein kinase II subunit alpha, ARC1502, 8-[4,5,6,7-tetrakis(bromanyl)benzimidazol-1-yl]octanoic acid, ... (4 entities in total) |
Functional Keywords | protein kinase ck2 casein kinase 2 bisubstrate inhibitor, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 41480.38 |
Authors | Niefind, K.,Schnitzler, A. (deposition date: 2019-09-03, release date: 2020-01-29, Last modification date: 2024-01-24) |
Primary citation | Pietsch, M.,Viht, K.,Schnitzler, A.,Ekambaram, R.,Steinkruger, M.,Enkvist, E.,Nienberg, C.,Nickelsen, A.,Lauwers, M.,Jose, J.,Uri, A.,Niefind, K. Unexpected CK2 beta-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2. Bioorg.Chem., 96:103608-103608, 2020 Cited by PubMed: 32058103DOI: 10.1016/j.bioorg.2020.103608 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.994 Å) |
Structure validation
Download full validation report