7B8I

Tetragonal structure of human protein kinase CK2 catalytic subunit in complex with a heparin oligo saccharide

Summary for 7B8I

• Entry DOI: 10.2210/pdb7b8i/pdb
• Related: 7B8H
• Descriptor: Casein kinase II subunit alpha, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, GLYCEROL, ... (5 entities in total)
• Functional Keywords: protein kinase ck2, casein kinase 2, catalytic subunit ck2alpha, heparin, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 82841.66

Authors

Niefind, K.,Schnitzler, A. (deposition date: 2020-12-12, release date: 2021-02-03, Last modification date: 2024-01-31)

• Primary citation: Schnitzler, A.,Niefind, K.; Structural basis for the design of bisubstrate inhibitors of protein kinase CK2 provided by complex structures with the substrate-competitive inhibitor heparin.; Eur.J.Med.Chem., 214:113223-113223, 2021; PubMed: 33571828; DOI: 10.1016/j.ejmech.2021.113223

Experimental method

X-RAY DIFFRACTION (2.55 Å)