5M4C
Complex structure of human protein kinase CK2 catalytic subunit with a thieno[2,3-d]pyrimidin inhibitor crystallized under low-salt conditions
Summary for 5M4C
Entry DOI | 10.2210/pdb5m4c/pdb |
Related | 5M44 |
Descriptor | Casein kinase II subunit alpha, 3-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylpropanoic acid, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | protein kinase ck2, casein kinase 2, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P68400 |
Total number of polymer chains | 1 |
Total formula weight | 40616.81 |
Authors | Niefind, K.,Bischoff, N.,Yarmoluk, S.M.,Bdzhola, V.G.,Golub, A.G.,Balanda, A.O.,Prykhod'ko, A.O. (deposition date: 2016-10-18, release date: 2017-01-18, Last modification date: 2024-01-17) |
Primary citation | Niefind, K.,Bischoff, N.,Golub, A.G.,Bdzhola, V.G.,Balanda, A.O.,Prykhod'ko, A.O.,Yarmoluk, S.M. Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor. Pharmaceuticals, 10:-, 2017 Cited by PubMed: 28085026DOI: 10.3390/ph10010009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.935 Å) |
Structure validation
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