5M4C

Complex structure of human protein kinase CK2 catalytic subunit with a thieno[2,3-d]pyrimidin inhibitor crystallized under low-salt conditions

Summary for 5M4C

Entry DOI	10.2210/pdb5m4c/pdb
Related	5M44
Descriptor	Casein kinase II subunit alpha, 3-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylpropanoic acid, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	protein kinase ck2, casein kinase 2, transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P68400
Total number of polymer chains	1
Total formula weight	40616.81
Authors	Niefind, K.,Bischoff, N.,Yarmoluk, S.M.,Bdzhola, V.G.,Golub, A.G.,Balanda, A.O.,Prykhod'ko, A.O. (deposition date: 2016-10-18, release date: 2017-01-18, Last modification date: 2024-01-17)
Primary citation	Niefind, K.,Bischoff, N.,Golub, A.G.,Bdzhola, V.G.,Balanda, A.O.,Prykhod'ko, A.O.,Yarmoluk, S.M. Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor. Pharmaceuticals, 10:-, 2017 Cited by PubMed: 28085026 DOI: 10.3390/ph10010009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.935 Å)

Structure validation