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4YFX
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BU of 4yfx by Molmil
Escherichia coli RNA polymerase in complex with Myxopyronin B
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S.
登録日2015-02-25
公開日2015-03-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.844 Å)
主引用文献X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein.
J.Med.Chem., 58, 2015
4YFK
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BU of 4yfk by Molmil
Escherichia coli RNA polymerase in complex with squaramide compound 8.
分子名称: 3,5-dimethyl-N-{2-[4-(4-methylbenzyl)piperidin-1-yl]-3,4-dioxocyclobut-1-en-1-yl}-1,2-oxazole-4-sulfonamide, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S.
登録日2015-02-25
公開日2015-03-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.571 Å)
主引用文献X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein.
J.Med.Chem., 58, 2015
4YFN
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BU of 4yfn by Molmil
Escherichia coli RNA polymerase in complex with squaramide compound 14 (N-[3,4-dioxo-2-(4-{[4-(trifluoromethyl)benzyl]amino}piperidin-1-yl)cyclobut-1-en-1-yl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide)
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S.
登録日2015-02-25
公開日2015-03-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.817 Å)
主引用文献X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein.
J.Med.Chem., 58, 2015
8E3H
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BU of 8e3h by Molmil
Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, Mg-ADP-BeF3, and NusG; Rho hexamer part
分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ...
著者Molodtsov, V, Wang, C.
登録日2022-08-17
公開日2022-09-07
最終更新日2023-02-22
実験手法ELECTRON MICROSCOPY (6.5 Å)
主引用文献Structural basis of Rho-dependent transcription termination.
Nature, 614, 2023
8E6X
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BU of 8e6x by Molmil
Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, lambda-tR1 rut RNA, Mg-ADP-BeF3, and NusG; TEC part
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Wang, C.
登録日2022-08-23
公開日2022-09-07
最終更新日2023-02-22
実験手法ELECTRON MICROSCOPY (4.27 Å)
主引用文献Structural basis of Rho-dependent transcription termination.
Nature, 614, 2023
8E3F
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BU of 8e3f by Molmil
Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, Mg-ADP-BeF3, and NusG; TEC part
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Wang, C.
登録日2022-08-17
公開日2022-09-07
最終更新日2023-02-22
実験手法ELECTRON MICROSCOPY (6.5 Å)
主引用文献Structural basis of Rho-dependent transcription termination.
Nature, 614, 2023
8E5L
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BU of 8e5l by Molmil
Escherichia coli Rho-dependent transcription pre-termination complex containing 21 nt long RNA spacer, Mg-ADP-BeF3, and NusG; Rho hexamer part
分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ...
著者Molodtsov, V, Wang, C.
登録日2022-08-22
公開日2022-09-07
最終更新日2023-02-22
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structural basis of Rho-dependent transcription termination.
Nature, 614, 2023
8E6W
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BU of 8e6w by Molmil
Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, lambda-tR1 rut RNA, Mg-ADP-BeF3, and NusG; Rho part
分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ...
著者Molodtsov, V, Wang, C, Ebright, R.H.
登録日2022-08-23
公開日2022-09-07
最終更新日2023-02-22
実験手法ELECTRON MICROSCOPY (4.27 Å)
主引用文献Structural basis of Rho-dependent transcription termination.
Nature, 614, 2023
8E6Z
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BU of 8e6z by Molmil
Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, dC75 rut mimic RNA, Mg-ADP-BeF3, and NusG; TEC part
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Wang, C, Ebright, R.H.
登録日2022-08-23
公開日2022-09-07
最終更新日2023-02-22
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural basis of Rho-dependent transcription termination.
Nature, 614, 2023
8E5P
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BU of 8e5p by Molmil
Escherichia coli Rho-dependent transcription pre-termination complex containing 24 nt long RNA spacer, Mg-ADP-BeF3, and NusG; Rho hexamer part
分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ...
著者Molodtsov, V, Wang, C.
登録日2022-08-22
公開日2022-09-07
最終更新日2023-02-22
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Structural basis of Rho-dependent transcription termination.
Nature, 614, 2023
8E5O
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BU of 8e5o by Molmil
Escherichia coli Rho-dependent transcription pre-termination complex containing 24 nt long RNA spacer, Mg-ADP-BeF3, and NusG; TEC part
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Wang, C.
登録日2022-08-22
公開日2022-09-07
最終更新日2023-02-22
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Structural basis of Rho-dependent transcription termination.
Nature, 614, 2023
8E70
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BU of 8e70 by Molmil
Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, dC75 rut mimic RNA, Mg-ADP-BeF3, and NusG; Rho hexamer part
分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ...
著者Molodtsov, V, Wang, C, Ebright, R.H.
登録日2022-08-23
公開日2022-09-07
最終更新日2023-02-22
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structural basis of Rho-dependent transcription termination.
Nature, 614, 2023
8E5K
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BU of 8e5k by Molmil
Escherichia coli Rho-dependent transcription pre-termination complex containing 21 nt long RNA spacer, Mg-ADP-BeF3, and NusG; TEC part
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Wang, C.
登録日2022-08-22
公開日2022-09-07
最終更新日2023-02-22
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structural basis of Rho-dependent transcription termination.
Nature, 614, 2023
6DT7
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BU of 6dt7 by Molmil
Bacteriophage N4 RNA polymerase II and DNA complex
分子名称: DNA (5'-D(P*CP*CP*AP*CP*CP*TP*GP*CP*A)-3'), RNAP1, RNAP2
著者Molodtsov, V, Murakami, K.S.
登録日2018-06-15
公開日2018-07-11
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Minimalism and functionality: Structural lessons from the heterodimeric N4 bacteriophage RNA polymerase II.
J. Biol. Chem., 293, 2018
6DT8
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BU of 6dt8 by Molmil
Bacteriophage N4 RNA polymerase II elongation complex 1
分子名称: DNA (5'-D(P*AP*CP*CP*CP*AP*CP*CP*AP*AP*AP*AP*A)-3'), RNA (5'-R(P*UP*GP*GP*UP*GP*G)-3'), RNAP1, ...
著者Molodtsov, V, Murakami, K.S.
登録日2018-06-15
公開日2018-07-11
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Minimalism and functionality: Structural lessons from the heterodimeric N4 bacteriophage RNA polymerase II.
J. Biol. Chem., 293, 2018
6DTA
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BU of 6dta by Molmil
Bacteriophage N4 RNA polymerase II elongation complex 2
分子名称: DNA (5'-D(P*CP*CP*CP*AP*CP*CP*AP*AP*AP*AP*A)-3'), GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Molodtsov, V, Murakami, K.S.
登録日2018-06-15
公開日2018-07-11
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.694 Å)
主引用文献Minimalism and functionality: Structural lessons from the heterodimeric N4 bacteriophage RNA polymerase II.
J. Biol. Chem., 293, 2018
5UAG
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BU of 5uag by Molmil
Escherichia coli RNA polymerase mutant - RpoB D516V
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S.
登録日2016-12-19
公開日2017-02-08
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.399 Å)
主引用文献Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
5UAQ
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BU of 5uaq by Molmil
Escherichia coli RNA polymerase RpoB H526Y mutant
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S.
登録日2016-12-19
公開日2017-01-11
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
5UAJ
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BU of 5uaj by Molmil
Escherichia coli RNA polymerase RpoB S531L mutant
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S.
登録日2016-12-19
公開日2017-01-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.915 Å)
主引用文献Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
5UAL
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BU of 5ual by Molmil
Escherichia coli RNA polymerase and Rifampin complex, RpoB S531L mutant
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S.
登録日2016-12-19
公開日2017-01-11
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.887 Å)
主引用文献Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
5UAH
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BU of 5uah by Molmil
Escherichia coli RNA polymerase and Rifampin complex, RpoB D516V mutant
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S.
登録日2016-12-19
公開日2017-01-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (4.1 Å)
主引用文献Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
5UAC
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BU of 5uac by Molmil
Escherichia coli RNA polymerase and Rifampin complex, wild-type
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S.
登録日2016-12-19
公開日2017-01-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
7U22
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BU of 7u22 by Molmil
Mycobacterium tuberculosis RNA polymerase sigma A holoenzyme open promoter complex containing UMN-7
分子名称: (9S,14S,15R,16S,17R,18R,19R,20S,21S,25R)-5,6,18,20-tetrahydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-10,26-dioxo-1,3,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl benzoate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Molodtsov, V, Ebright, R.H.
登録日2022-02-22
公開日2022-10-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.87 Å)
主引用文献Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance.
Angew.Chem.Int.Ed.Engl., 61, 2022
7RWI
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BU of 7rwi by Molmil
Mycobacterium tuberculosis RNA polymerase sigma L holoenzyme open promoter complex containing TNP-2198
分子名称: (3aM,9S,10bP,14S,15R,16S,17R,18R,19R,20S,21S,25R)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]-5,10,26-trioxo-3,5,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl acetate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Molodtsov, V, Ebright, R.H.
登録日2021-08-19
公開日2022-03-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
J.Med.Chem., 65, 2022
6TYF
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BU of 6tyf by Molmil
Crystal structure of MTB sigma L transcription initiation complex with 6 nt long RNA primer
分子名称: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*AP*TP*CP*GP*AP*GP*GP*GP*T)-3'), DNA (5'-D(P*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Molodtsov, V, Ebright, R.H.
登録日2019-08-08
公開日2020-03-11
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020

 

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