5W83
 
 | | Rpn8/Rpn11 dimer complex | | 分子名称: | 26S proteasome regulatory subunit RPN8, Ubiquitin carboxyl-terminal hydrolase RPN11, ZINC ION | | 著者 | Dong, K.C, Worden, E.J, Martin, A. | | 登録日 | 2017-06-21 | | 公開日 | 2017-09-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.554 Å) | | 主引用文献 | An AAA Motor-Driven Mechanical Switch in Rpn11 Controls Deubiquitination at the 26S Proteasome.
Mol. Cell, 67, 2017
|
|
7Q8V
 | | Crystal structure of TTBK1 in complex with VNG2.73 (compound 42) | | 分子名称: | PHOSPHATE ION, Tau-tubulin kinase 1, ~{N}-[4-(2-chloranylphenoxy)phenyl]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine | | 著者 | Chaikuad, A, Nozal, V, Martinez, A, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2021-11-11 | | 公開日 | 2022-03-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
J.Med.Chem., 65, 2022
|
|
7Q8Y
 | | Crystal structure of TTBK2 in complex with VNG2.73 (compound 42) | | 分子名称: | PHOSPHATE ION, Tau-tubulin kinase 2, ~{N}-[4-(2-chloranylphenoxy)phenyl]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine | | 著者 | Chaikuad, A, Nozal, V, Martinez, A, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2021-11-11 | | 公開日 | 2022-03-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
J.Med.Chem., 65, 2022
|
|
7Q8Z
 | | Crystal structure of TTBK2 in complex with VNG1.33 (compound 27) | | 分子名称: | PHOSPHATE ION, Tau-tubulin kinase 2, ~{N}-(4-phenoxyphenyl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine | | 著者 | Chaikuad, A, Nozal, V, Martinez, A, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2021-11-11 | | 公開日 | 2022-03-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
J.Med.Chem., 65, 2022
|
|
7Q8W
 | | Crystal structure of TTBK1 in complex with VNG1.35 (compound 23) | | 分子名称: | 1,2-ETHANEDIOL, PHOSPHATE ION, Tau-tubulin kinase 1, ... | | 著者 | Chaikuad, A, Nozal, V, Martinez, A, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2021-11-11 | | 公開日 | 2022-03-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
J.Med.Chem., 65, 2022
|
|
7Q90
 | | Crystal structure of TTBK2 in complex with VNG1.63 (compound 32) | | 分子名称: | PHOSPHATE ION, Tau-tubulin kinase 2, ~{N}-[4-(4-methoxyphenoxy)phenyl]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine | | 著者 | Chaikuad, A, Nozal, V, Martinez, A, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2021-11-11 | | 公開日 | 2022-03-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
J.Med.Chem., 65, 2022
|
|
6XF9
 | | Crystal structure of KSHV ORF68 | | 分子名称: | Packaging protein UL32, ZINC ION | | 著者 | Didychuk, A.L, Gates, S.N, Martin, A, Glaunsinger, B. | | 登録日 | 2020-06-15 | | 公開日 | 2021-02-24 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | A pentameric protein ring with novel architecture is required for herpesviral packaging.
Elife, 10, 2021
|
|
6XFA
 | | Cryo-EM structure of EBV BFLF1 | | 分子名称: | Packaging protein UL32, ZINC ION | | 著者 | Didychuk, A.L, Gates, S.N, Martin, A, Glaunsinger, B. | | 登録日 | 2020-06-15 | | 公開日 | 2021-02-24 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | A pentameric protein ring with novel architecture is required for herpesviral packaging.
Elife, 10, 2021
|
|
3J47
 | | Formation of an intricate helical bundle dictates the assembly of the 26S proteasome lid | | 分子名称: | 26S proteasome regulatory subunit RPN11, 26S proteasome regulatory subunit RPN12, 26S proteasome regulatory subunit RPN3, ... | | 著者 | Estrin, E, Lopez-Blanco, J.R, Chacon, P, Martin, A. | | 登録日 | 2013-06-27 | | 公開日 | 2013-08-28 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | | 主引用文献 | Formation of an Intricate Helical Bundle Dictates the Assembly of the 26S Proteasome Lid.
Structure, 21, 2013
|
|
7Q6L
 | |
7Q48
 | |
1HZF
 | | C4ADG FRAGMENT OF HUMAN COMPLEMENT FACTOR C4A | | 分子名称: | COMPLEMENT FACTOR C4A | | 著者 | van den Elsen, J.M.H, Martin, A, Wong, V, Clemenza, L, Rose, D.R, Isenman, D.E. | | 登録日 | 2001-01-24 | | 公開日 | 2002-10-09 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | X-ray crystal structure of the C4d fragment of human complement component C4.
J.Mol.Biol., 322, 2002
|
|
3JCK
 | | Structure of the yeast 26S proteasome lid sub-complex | | 分子名称: | 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit RPN12, 26S proteasome regulatory subunit RPN3, ... | | 著者 | Herzik Jr, M.A, Dambacher, C.M, Worden, E.J, Martin, A, Lander, G.C. | | 登録日 | 2015-12-20 | | 公開日 | 2016-01-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.
Elife, 5, 2016
|
|
3HWS
 | | Crystal structure of nucleotide-bound hexameric ClpX | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit clpX, MAGNESIUM ION, ... | | 著者 | Glynn, S.E, Martin, A, Baker, T.A, Sauer, R.T. | | 登録日 | 2009-06-18 | | 公開日 | 2009-11-24 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine.
Cell(Cambridge,Mass.), 139, 2009
|
|
3HTE
 | | Crystal structure of nucleotide-free hexameric ClpX | | 分子名称: | ATP-dependent Clp protease ATP-binding subunit clpX, SULFATE ION | | 著者 | Glynn, S.E, Martin, A, Baker, T.A, Sauer, R.T. | | 登録日 | 2009-06-11 | | 公開日 | 2009-11-24 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (4.026 Å) | | 主引用文献 | Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine.
Cell(Cambridge,Mass.), 139, 2009
|
|
6EF0
 | | Yeast 26S proteasome bound to ubiquitinated substrate (1D* motor state) | | 分子名称: | 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, 26S proteasome regulatory subunit 6B homolog, ... | | 著者 | de la Pena, A.H, Goodall, E.A, Gates, S.N, Lander, G.C, Martin, A. | | 登録日 | 2018-08-15 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.43 Å) | | 主引用文献 | Substrate-engaged 26Sproteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation.
Science, 362, 2018
|
|
6EF2
 | | Yeast 26S proteasome bound to ubiquitinated substrate (5T motor state) | | 分子名称: | 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, 26S proteasome regulatory subunit 6B homolog, ... | | 著者 | de la Pena, A.H, Goodall, E.A, Gates, S.N, Lander, G.C, Martin, A. | | 登録日 | 2018-08-15 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.27 Å) | | 主引用文献 | Substrate-engaged 26Sproteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation.
Science, 362, 2018
|
|
6EF3
 | | Yeast 26S proteasome bound to ubiquitinated substrate (4D motor state) | | 分子名称: | 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, 26S proteasome regulatory subunit 6B homolog, ... | | 著者 | de la Pena, A.H, Goodall, E.A, Gates, S.N, Lander, G.C, Martin, A. | | 登録日 | 2018-08-15 | | 公開日 | 2018-10-17 | | 最終更新日 | 2020-01-08 | | 実験手法 | ELECTRON MICROSCOPY (4.17 Å) | | 主引用文献 | Substrate-engaged 26Sproteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation.
Science, 362, 2018
|
|
6EF1
 | | Yeast 26S proteasome bound to ubiquitinated substrate (5D motor state) | | 分子名称: | 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, 26S proteasome regulatory subunit 6B homolog, ... | | 著者 | de la Pena, A.H, Goodall, E.A, Gates, S.N, Lander, G.C, Martin, A. | | 登録日 | 2018-08-15 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.73 Å) | | 主引用文献 | Substrate-engaged 26Sproteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation.
Science, 362, 2018
|
|
4U39
 | | Crystal Structure of FtsZ:MciZ Complex from Bacillus subtilis | | 分子名称: | Cell division factor, Cell division protein FtsZ, PHOSPHATE ION | | 著者 | Bisson-Filho, A.W, Discola, K.F, Castellen, P, Blasios, V, Martins, A, Sforca, M.L, Garcia, W, Zeri, A.C, Erickson, H.P, Dessen, A, Gueiros-Filho, F.J. | | 登録日 | 2014-07-19 | | 公開日 | 2015-03-18 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.194 Å) | | 主引用文献 | Crystal Structure of FtsZ:MciZ Complex from Bacillus subtilis
To be Published
|
|
4O8X
 | | Zinc-bound Rpn11 in complex with Rpn8 | | 分子名称: | 1,2-ETHANEDIOL, 26S proteasome regulatory subunit RPN11, 26S proteasome regulatory subunit RPN8, ... | | 著者 | Worden, E.J, Padovani, C, Martin, A. | | 登録日 | 2013-12-30 | | 公開日 | 2014-01-22 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.991 Å) | | 主引用文献 | Structure of the Rpn11-Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation.
Nat.Struct.Mol.Biol., 21, 2014
|
|
4O8Y
 | | Zinc-free Rpn11 in complex with Rpn8 | | 分子名称: | 1,2-ETHANEDIOL, 26S proteasome regulatory subunit RPN11, 26S proteasome regulatory subunit RPN8 | | 著者 | Worden, E.J, Padovani, C, Martin, A. | | 登録日 | 2013-12-30 | | 公開日 | 2014-01-22 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure of the Rpn11-Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation.
Nat.Struct.Mol.Biol., 21, 2014
|
|
2LZP
 | |
2LZQ
 | |
2MKB
 | |
