8EMW
 
 | | Phospholipase C beta 3 (PLCb3) in complex with Gbg on liposomes | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Falzone, M.E, MacKinnon, R. | | 登録日 | 2022-09-28 | | 公開日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
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6V3G
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6UQF
 | | Human HCN1 channel in a hyperpolarized conformation | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, MERCURY (II) ION, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | | 著者 | Lee, C.-H, MacKinnon, R. | | 登録日 | 2019-10-19 | | 公開日 | 2019-12-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Voltage Sensor Movements during Hyperpolarization in the HCN Channel.
Cell, 179, 2019
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6UWM
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6UQG
 | | Human HCN1 channel Y289D mutant | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | | 著者 | Lee, C.-H, MacKinnon, R. | | 登録日 | 2019-10-19 | | 公開日 | 2019-12-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Voltage Sensor Movements during Hyperpolarization in the HCN Channel.
Cell, 179, 2019
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6V35
 | | Cryo-EM structure of Ca2+-free hsSlo1-beta4 channel complex | | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | 著者 | Tao, X, MacKinnon, R. | | 登録日 | 2019-11-25 | | 公開日 | 2019-12-25 | | 最終更新日 | 2020-10-07 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Molecular structures of the human Slo1 K + channel in complex with beta 4.
Elife, 8, 2019
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6V22
 | | Cryo-EM structure of Ca2+-bound hsSlo1-beta4 channel complex | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Tao, X, MacKinnon, R. | | 登録日 | 2019-11-22 | | 公開日 | 2019-12-25 | | 最終更新日 | 2020-10-07 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Molecular structures of the human Slo1 K + channel in complex with beta 4.
Elife, 8, 2019
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6V38
 | | Cryo-EM structure of Ca2+-bound hsSlo1 channel | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL, ... | | 著者 | Tao, X, MacKinnon, R. | | 登録日 | 2019-11-25 | | 公開日 | 2019-12-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Molecular structures of the human Slo1 K + channel in complex with beta 4.
Elife, 8, 2019
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6PBY
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6PBX
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7S5V
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7S5T
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7S61
 | | Human KATP channel in open conformation, focused on Kir and one SUR, position 5 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | | 著者 | Zhao, C, MacKinnon, R. | | 登録日 | 2021-09-12 | | 公開日 | 2021-12-01 | | 最終更新日 | 2021-12-08 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7S60
 | | Human KATP channel in open conformation, focused on Kir and one SUR, position 4 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | | 著者 | Zhao, C, MacKinnon, R. | | 登録日 | 2021-09-12 | | 公開日 | 2021-12-01 | | 最終更新日 | 2021-12-08 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7S5X
 | | Human KATP channel in open conformation, focused on Kir and one SUR, position 1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | | 著者 | Zhao, C, MacKinnon, R. | | 登録日 | 2021-09-12 | | 公開日 | 2021-12-01 | | 最終更新日 | 2021-12-08 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
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1LNQ
 | | CRYSTAL STRUCTURE OF MTHK AT 3.3 A | | 分子名称: | CALCIUM ION, POTASSIUM CHANNEL RELATED PROTEIN | | 著者 | Jiang, Y, Lee, A, Chen, J, Cadene, M, Chait, B.T, Mackinnon, R. | | 登録日 | 2002-05-03 | | 公開日 | 2002-06-19 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | CRYSTAL STRUCTURE AND MECHANISM OF A CALCIUM-GATED POTASSIUM CHANNEL
Nature, 417, 2002
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1KPK
 | | Crystal Structure of the ClC Chloride Channel from E. coli | | 分子名称: | putative channel transporter | | 著者 | Dutzler, R, Campbell, E.B, Cadene, M, Chait, B.T, MacKinnon, R. | | 登録日 | 2001-12-31 | | 公開日 | 2002-01-23 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of
anion selectivity.
Nature, 415, 2002
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1KPL
 | | Crystal Structure of the ClC Chloride Channel from S. typhimurium | | 分子名称: | CHLORIDE ION, N-OCTANE, PENTADECANE, ... | | 著者 | Dutzler, R, Campbell, E.B, Cadene, M, Chait, B.T, MacKinnon, R. | | 登録日 | 2001-12-31 | | 公開日 | 2002-01-23 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of
anion selectivity.
Nature, 415, 2002
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1OTS
 | | Structure of the Escherichia coli ClC Chloride channel and Fab Complex | | 分子名称: | CHLORIDE ION, Fab fragment (heavy chain), Fab fragment (light chain), ... | | 著者 | Dutzler, R, Campbell, E.B, MacKinnon, R. | | 登録日 | 2003-03-22 | | 公開日 | 2003-04-15 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Gating the Selectivity Filter in ClC Chloride Channels
Science, 300, 2003
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1OTU
 | | Structure of the Escherichia coli ClC Chloride channel E148Q mutant and Fab Complex | | 分子名称: | CHLORIDE ION, Fab fragment (Heavy chain), Fab fragment (Light chain), ... | | 著者 | Dutzler, R, Campbell, E.B, MacKinnon, R. | | 登録日 | 2003-03-23 | | 公開日 | 2003-04-15 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Gating the Selectivity Filter in ClC Chloride Channels
Science, 300, 2003
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1OTT
 | | Structure of the Escherichia coli ClC Chloride channel E148A mutant and Fab Complex | | 分子名称: | CHLORIDE ION, Fab fragment (Heavy chain), Fab fragment (Light chain), ... | | 著者 | Dutzler, R, Campbell, E.B, MacKinnon, R. | | 登録日 | 2003-03-23 | | 公開日 | 2003-04-15 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Gating the Selectivity Filter in ClC Chloride Channels
Science, 300, 2003
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2H8P
 | | Structure of a K channel with an amide to ester substitution in the selectivity filter | | 分子名称: | (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE, FAB heavy chain, FAB light chain, ... | | 著者 | Valiyaveetil, F.I, MacKinnon, R, Muir, T.W. | | 登録日 | 2006-06-07 | | 公開日 | 2006-09-12 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural and Functional Consequences of an Amide-to-Ester Substitution in the Selectivity Filter of a Potassium Channel.
J.Am.Chem.Soc., 128, 2006
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2HFE
 | | Rb+ complex of a K channel with an amide to ester substitution in the selectivity filter | | 分子名称: | (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE, FAB Heavy Chain, FAB Light Chain, ... | | 著者 | Valiyaveetil, F.I, MacKinnon, R, Muir, T.W. | | 登録日 | 2006-06-23 | | 公開日 | 2006-09-12 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural and Functional Consequences of an Amide-to-Ester Substitution in the Selectivity Filter of a Potassium Channel.
J.Am.Chem.Soc., 128, 2006
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2HG5
 | | Cs+ complex of a K channel with an amide to ester substitution in the selectivity filter | | 分子名称: | (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE, CESIUM ION, FAB HEAVY CHAIN, ... | | 著者 | Valiyaveetil, F.I, MacKinnon, R, Muir, T.W. | | 登録日 | 2006-06-26 | | 公開日 | 2006-09-12 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structural and Functional Consequences of an Amide-to-Ester Substitution in the Selectivity Filter of a Potassium Channel.
J.Am.Chem.Soc., 128, 2006
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5VA2
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