8IJT
 
 | | crystal structure of Hyp N135A mutant from Hypoxylon sp. E7406B | | Descriptor: | Terpene synthase | | Authors: | Gao, J, Su, L.Q, Li, Q, Han, X, Wei, H.L, Dai, Z.J, Liu, W.D. | | Deposit date: | 2023-02-28 | | Release date: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.56 Å) | | Cite: | crystal structure of Hyp N135A mutant from Hypoxylon sp. E7406B
to be published
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8JUN
 | | Cryo-EM structure of SIDT1 E555Q mutant | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SID1 transmembrane family member 1, ZINC ION | | Authors: | Sun, C.R, Xu, D, Li, Q, Zhou, C.Z, Chen, Y. | | Deposit date: | 2023-06-26 | | Release date: | 2023-11-15 | | Last modified: | 2024-01-24 | | Method: | ELECTRON MICROSCOPY (2.38 Å) | | Cite: | Human SIDT1 mediates dsRNA uptake via its phospholipase activity.
Cell Res., 34, 2024
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8JUL
 | | Cryo-EM structure of SIDT1 in complex with phosphatidic acid | | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, SID1 transmembrane family member 1, ZINC ION | | Authors: | Sun, C.R, Xu, D, Li, Q, Zhou, C.Z, Chen, Y. | | Deposit date: | 2023-06-26 | | Release date: | 2023-11-15 | | Last modified: | 2024-01-24 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Human SIDT1 mediates dsRNA uptake via its phospholipase activity.
Cell Res., 34, 2024
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8KEF
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8KEG
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8KEC
 | | Cyanophage A-1(L) tail fiber | | Descriptor: | Long tail fiber, short tail fiber | | Authors: | Yu, R.C, Li, Q, Zhou, C.Z. | | Deposit date: | 2023-08-11 | | Release date: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structure of the intact tail machine of Anabaena myophage A-1(L).
Nat Commun, 15, 2024
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8KEE
 | | Cyanophage A-1(L) sheath-tube | | Descriptor: | sheath, tube | | Authors: | Yu, R.C, Li, Q, Zhou, C.Z. | | Deposit date: | 2023-08-11 | | Release date: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Structure of the intact tail machine of Anabaena myophage A-1(L).
Nat Commun, 15, 2024
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8KEA
 | | Cyanophage A-1(L) baseplate-initiators | | Descriptor: | baseplate gp16, central spike, hub, ... | | Authors: | Yu, R.C, Li, Q, Zhou, C.Z. | | Deposit date: | 2023-08-11 | | Release date: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Structure of the intact tail machine of Anabaena myophage A-1(L).
Nat Commun, 15, 2024
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8KE9
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6JYX
 | | Structure of CbpJ from Streptococcus Pneumoniae TIGR4 | | Descriptor: | CHOLINE ION, Choline binding protein J, DI(HYDROXYETHYL)ETHER | | Authors: | Xu, Q, Zhang, J.W, Li, Q, Jiang, Y.L. | | Deposit date: | 2019-04-29 | | Release date: | 2019-06-05 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of the choline-binding protein CbpJ from Streptococcus pneumoniae.
Biochem.Biophys.Res.Commun., 514, 2019
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6L2W
 | | Crystal structure of a novel fold protein Gp72 from the freshwater cyanophage Mic1 | | Descriptor: | freshwater cyanophage protein | | Authors: | Wang, Y, Jin, H, Yang, F, Jiang, Y.L, Zhao, Y.Y, Chen, Z.P, Li, W.F, Chen, Y, Zhou, C.Z, Li, Q. | | Deposit date: | 2019-10-07 | | Release date: | 2020-05-13 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Crystal structure of a novel fold protein Gp72 from the freshwater cyanophage Mic1.
Proteins, 88, 2020
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6LKC
 | | Crystal structure of PfaD from Shewanella piezotolerans in complex with FMN | | Descriptor: | CALCIUM ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | | Authors: | Zhang, M.L, Li, Q, Meng, S.S, Guo, L.J, He, L, Huang, J.Z, Li, L, Zhang, H.D. | | Deposit date: | 2019-12-19 | | Release date: | 2020-12-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.998 Å) | | Cite: | Structural Insights into the Trans -Acting Enoyl Reductase in the Biosynthesis of Long-Chain Polyunsaturated Fatty Acids in Shewanella piezotolerans .
J.Agric.Food Chem., 69, 2021
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7VPB
 | | Crystal structure of a novel hydrolase in apo form | | Descriptor: | 4-(2-hydroxyethylcarbamoyl)benzoic acid, ACETATE ION, plastic degrading hydrolase Ple629 | | Authors: | Wu, P, Zhao, Y.P, Li, Z.S, Ingrid, M.C, Lara, P, Gao, J, Han, X, Li, Q, Basak, O, Liu, W.D, Wei, R. | | Deposit date: | 2021-10-15 | | Release date: | 2022-10-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Structural insight and engineering of a plastic degrading hydrolase Ple629.
Biochem.Biophys.Res.Commun., 626, 2022
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7VME
 | | Crystal structure of a hydrolase in apo form 2 | | Descriptor: | CALCIUM ION, hydrolase | | Authors: | Wu, P, Zhao, Y.P, Li, Z.S, Ingrid, M.C, Lara, P, Gao, J, Han, X, Li, Q, Basak, O, Liu, W.D, Wei, R. | | Deposit date: | 2021-10-08 | | Release date: | 2022-10-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Crystal structure of a hydrolase in apo form 2
to be published
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5YAT
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6JBX
 | | Crystal structure of Streptococcus pneumoniae FabT in complex with DNA | | Descriptor: | DNA (5'-D(*AP*AP*TP*AP*GP*TP*TP*TP*GP*AP*CP*TP*GP*TP*CP*AP*AP*AP*TP*TP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*AP*AP*TP*TP*TP*GP*AP*CP*AP*GP*TP*CP*AP*AP*AP*CP*TP*AP*TP*T)-3'), Fatty acid biosynthesis transcriptional regulator, ... | | Authors: | Zuo, G, Chen, Z.P, Li, Q, Zhou, C.Z. | | Deposit date: | 2019-01-27 | | Release date: | 2019-07-24 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural insights into repression of the Pneumococcal fatty acid synthesis pathway by repressor FabT and co-repressor acyl-ACP.
Febs Lett., 593, 2019
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6JY5
 | | Structure of CsoS4B from Halothiobacillus neapolitanus | | Descriptor: | Unidentified carboxysome polypeptide | | Authors: | Zhao, Y.Y, Jiang, Y.L, Chen, Y, Zhou, C.Z, Li, Q. | | Deposit date: | 2019-04-26 | | Release date: | 2019-06-26 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Crystal structure of pentameric shell protein CsoS4B of Halothiobacillus neapolitanus alpha-carboxysome.
Biochem.Biophys.Res.Commun., 515, 2019
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6L5D
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6CDY
 | | Crystal structure of TEAD complexed with its inhibitor | | Descriptor: | 2-[(4H-1,2,4-triazol-3-yl)sulfanyl]-N-{4-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]phenyl}acetamide, Transcriptional enhancer factor TEF-4 | | Authors: | LIU, S, HAN, X, LUO, X. | | Deposit date: | 2018-02-09 | | Release date: | 2020-07-01 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.
Cell Stem Cell, 26, 2020
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2F7E
 | | PKA complexed with (S)-2-(1H-Indol-3-yl)-1-(5-isoquinolin-6-yl-pyridin-3-yloxymethyl-etylamine | | Descriptor: | (1S)-2-(1H-INDOL-3-YL)-1-{[(5-ISOQUINOLIN-6-YLPYRIDIN-3-YL)OXY]METHYL}ETHYLAMINE, PKI inhibitory peptide, cAMP-dependent protein kinase, ... | | Authors: | Stoll, V.S. | | Deposit date: | 2005-11-30 | | Release date: | 2006-06-27 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
Bioorg.Med.Chem.Lett., 16, 2006
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8E30
 | | E. coli 50S ribosome bound to compound streptogramin A analog 3142 | | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L15, ... | | Authors: | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | | Deposit date: | 2022-08-16 | | Release date: | 2023-06-28 | | Method: | ELECTRON MICROSCOPY (1.91 Å) | | Cite: | Potential for clicked streptogramin analogs
To Be Published
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8E43
 | | E. coli 50S ribosome bound to compound streptogramin A analog 3336 | | Descriptor: | (2R)-2-[(3S,4R,5E,10E,12E,14S,16R,23S,26aR)-16-fluoro-14-hydroxy-12-methyl-1,7,22-trioxo-4-(prop-2-en-1-yl)-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl isoquinolin-3-ylcarbamate, 23S ribosomal RNA, 50S ribosomal protein L13, ... | | Authors: | Pellegrino, J, Lee, D.J, Seiple, I.B, Fraser, J.S. | | Deposit date: | 2022-08-17 | | Release date: | 2023-06-28 | | Method: | ELECTRON MICROSCOPY (2.09 Å) | | Cite: | Streptogramin A analogs
To Be Published
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8E36
 | | E. coli 50S ribosome bound to compound streptogramin A analog 3146 | | Descriptor: | 2-[(3R,4R,5E,10E,12E,14S,16R,23S,26aR)-16-fluoro-14-hydroxy-12-methyl-1,7,22-trioxo-3-(propan-2-yl)-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-4-yl]-N-{2-[4-(pyridin-4-yl)-1H-1,2,3-triazol-1-yl]ethyl}acetamide, 23S ribosomal RNA, 50S ribosomal protein L13, ... | | Authors: | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | | Deposit date: | 2022-08-16 | | Release date: | 2023-06-28 | | Method: | ELECTRON MICROSCOPY (2.38 Å) | | Cite: | Potential for clicked streptogramin analogs
To Be Published
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7RSU
 | | TNA polymerase, n+2 product | | Descriptor: | DNA polymerase, Primer, Template | | Authors: | Maola, V, Chaput, J, Chim, N. | | Deposit date: | 2021-08-11 | | Release date: | 2021-10-27 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Synthesis and Polymerase Recognition of Threose Nucleic Acid Triphosphates Equipped with Diverse Chemical Functionalities.
J.Am.Chem.Soc., 143, 2021
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6WYV
 | | E. coli 50S ribosome bound to compounds 47 and VS1 | | Descriptor: | (3R,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-12-methyl-3-(propan-2-yl)-4-(prop-2-en-1-yl)-3,4,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,7H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,22-trione, 23S ribosomal RNA, 50S ribosomal protein L13, ... | | Authors: | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | | Deposit date: | 2020-05-13 | | Release date: | 2020-06-17 | | Last modified: | 2020-10-07 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | Synthetic group A streptogramin antibiotics that overcome Vat resistance.
Nature, 586, 2020
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