3IA5
 
 | | Moritella profunda dihydrofolate reductase (DHFR) | | 分子名称: | Dihydrofolate reductase, PHOSPHATE ION | | 著者 | Hay, S, Evans, R.M, Levy, C, Wang, X, Loveridge, E.J, Leys, D, Allemann, R.K, Scrutton, N.S. | | 登録日 | 2009-07-13 | | 公開日 | 2009-07-21 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Are the Catalytic Properties of Enzymes from Piezophilic Organisms Pressure Adapted?
Chembiochem, 10, 2009
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3IW2
 | | Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP125 in complex with econazole | | 分子名称: | 4-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, Cytochrome P450 CYP125, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | McLean, K.J, Levy, C, Munro, A.W, Leys, D. | | 登録日 | 2009-09-02 | | 公開日 | 2009-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.
J.Biol.Chem., 284, 2009
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3IP8
 | | Crystal structure of arylmalonate decarboxylase (AMDase) from Bordatella bronchiseptic in complex with benzylphosphonate | | 分子名称: | Arylmalonate decarboxylase, benzylphosphonic acid | | 著者 | Okrasa, K, Levy, C, Leys, D, Micklefield, J. | | 登録日 | 2009-08-17 | | 公開日 | 2009-10-06 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.498 Å) | | 主引用文献 | Structure-Guided Directed Evolution of Alkenyl and Arylmalonate Decarboxylases.
Angew.Chem.Int.Ed.Engl., 48, 2009
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3IW0
 | | Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP125, C2221 crystal form | | 分子名称: | Cytochrome P450 CYP125, PHOSPHATE ION, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | McLean, K.J, Levy, C, Munro, A.W, Leys, D. | | 登録日 | 2009-09-02 | | 公開日 | 2009-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.
J.Biol.Chem., 284, 2009
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3IW1
 | | Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP125 in complex with androstenedione | | 分子名称: | 4-ANDROSTENE-3-17-DIONE, Cytochrome P450 CYP125, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | McLean, K.J, Levy, C, Munro, A.W, Leys, D. | | 登録日 | 2009-09-02 | | 公開日 | 2009-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.
J.Biol.Chem., 284, 2009
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4J31
 | | Crystal Structure of kynurenine 3-monooxygenase (KMO-396Prot) | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Kynurenine 3-monooxygenase | | 著者 | Amaral, M, Levy, C, Heyes, D.J, Lafite, P, Outeiro, T.F, Giorgini, F, Leys, D, Scrutton, N.S. | | 登録日 | 2013-02-05 | | 公開日 | 2013-04-10 | | 最終更新日 | 2023-05-31 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis of kynurenine 3-monooxygenase inhibition.
Nature, 496, 2013
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4J2W
 | | Crystal Structure of kynurenine 3-monooxygenase (KMO-396Prot-Se) | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Kynurenine 3-monooxygenase | | 著者 | Amaral, M, Levy, C, Heyes, D.J, Lafite, P, Outeiro, T.F, Giorgini, F, Leys, D, Scrutton, N.S. | | 登録日 | 2013-02-05 | | 公開日 | 2013-04-10 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis of kynurenine 3-monooxygenase inhibition.
Nature, 496, 2013
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4J36
 | | Cocrystal Structure of kynurenine 3-monooxygenase in complex with UPF 648 inhibitor(KMO-394UPF) | | 分子名称: | (1S,2S)-2-(3,4-dichlorobenzoyl)cyclopropanecarboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE, Kynurenine 3-monooxygenase | | 著者 | Amaral, M, Levy, C, Heyes, D.J, Lafite, P, Outeiro, T.F, Giorgini, F, Leys, D, Scrutton, N.S. | | 登録日 | 2013-02-05 | | 公開日 | 2013-04-10 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | Structural basis of kynurenine 3-monooxygenase inhibition.
Nature, 496, 2013
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4J33
 | | Crystal Structure of kynurenine 3-monooxygenase (KMO-394) | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Kynurenine 3-monooxygenase | | 著者 | Amaral, M, Levy, C, Heyes, D.J, Lafite, P, Outeiro, T.F, Giorgini, F, Leys, D, Scrutton, N.S. | | 登録日 | 2013-02-05 | | 公開日 | 2013-04-10 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Structural basis of kynurenine 3-monooxygenase inhibition.
Nature, 496, 2013
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3KP0
 | | Crystal Structure of ORNITHINE 4,5 AMINOMUTASE in complex with 2,4-diaminobutyrate (DAB) (Aerobic) | | 分子名称: | (2S)-2-amino-4-{[(1Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}butanoic acid, 5'-DEOXYADENOSINE, COBALAMIN, ... | | 著者 | Wolthers, K.R, Levy, C.W, Scrutton, N.S, Leys, D. | | 登録日 | 2009-11-14 | | 公開日 | 2010-01-26 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase.
J.Biol.Chem., 285, 2010
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3KFT
 | | Crystal structure of Pentaerythritol Tetranitrate Reductase complex with 1,4,5,6-tetrahydro NADH | | 分子名称: | FLAVIN MONONUCLEOTIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pentaerythritol tetranitrate reductase | | 著者 | Pudney, C.R, Levy, C.W, Leys, D, Scrutton, N.S. | | 登録日 | 2009-10-28 | | 公開日 | 2010-02-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction.
J.Am.Chem.Soc., 131, 2009
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3KX5
 | | Crystal structure of Bacillus megaterium BM3 heme domain mutant F261E | | 分子名称: | Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | | 著者 | Girvan, H.M, Levy, C.W, Leys, D, Munro, A.W. | | 登録日 | 2009-12-02 | | 公開日 | 2010-05-19 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (1.686 Å) | | 主引用文献 | Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3.
Biochem.J., 427, 2010
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3KOY
 | | Crystal Structure of ornithine 4,5 aminomutase in complex with ornithine (Aerobic) | | 分子名称: | (E)-N~5~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-ornithine, 5'-DEOXYADENOSINE, COBALAMIN, ... | | 著者 | Wolthers, K.R, Levy, C.W, Scrutton, N.S, Leys, D. | | 登録日 | 2009-11-14 | | 公開日 | 2010-01-26 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase.
J.Biol.Chem., 285, 2010
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3KX3
 | | Crystal structure of Bacillus megaterium BM3 heme domain mutant L86E | | 分子名称: | Bifunctional P-450/NADPH-P450 reductase, N-PALMITOYLGLYCINE, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Girvan, H.M, Levy, C.W, Leys, D, Munro, A.W. | | 登録日 | 2009-12-02 | | 公開日 | 2010-05-19 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | | 主引用文献 | Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3.
Biochem.J., 427, 2010
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3KP1
 | | Crystal structure of ornithine 4,5 aminomutase (Resting State) | | 分子名称: | 5'-DEOXYADENOSINE, COBALAMIN, D-ornithine aminomutase E component, ... | | 著者 | Wolthers, K.R, Levy, C.W, Scrutton, N.S, Leys, D. | | 登録日 | 2009-11-14 | | 公開日 | 2010-01-26 | | 最終更新日 | 2019-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase.
J.Biol.Chem., 285, 2010
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3KRU
 | | Crystal Structure of the Thermostable Old Yellow Enzyme from Thermoanaerobacter pseudethanolicus E39 | | 分子名称: | ACETATE ION, FLAVIN MONONUCLEOTIDE, NADH:flavin oxidoreductase/NADH oxidase | | 著者 | Adalbjornsson, B.V, Toogood, H.S, Leys, D, Scrutton, N.S. | | 登録日 | 2009-11-19 | | 公開日 | 2009-12-08 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Biocatalysis with thermostable enzymes: structure and properties of a thermophilic 'ene'-reductase related to old yellow enzyme.
Chembiochem, 11, 2010
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3KOW
 | | Crystal Structure of ornithine 4,5 aminomutase backsoaked complex | | 分子名称: | 5'-DEOXYADENOSINE, COBALAMIN, D-ornithine aminomutase E component, ... | | 著者 | Wolthers, K.R, Levy, C.W, Scrutton, N.S, Leys, D. | | 登録日 | 2009-11-14 | | 公開日 | 2010-01-26 | | 最終更新日 | 2012-10-24 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase.
J.Biol.Chem., 285, 2010
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3KX4
 | | Crystal structure of Bacillus megaterium BM3 heme domain mutant I401E | | 分子名称: | Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Girvan, H.M, Levy, C.W, Leys, D, Munro, A.W. | | 登録日 | 2009-12-02 | | 公開日 | 2010-05-19 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3.
Biochem.J., 427, 2010
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3KOX
 | | Crystal Structure of ornithine 4,5 aminomutase in complex with 2,4-diaminobutyrate (Anaerobic) | | 分子名称: | (2S)-2-amino-4-{[(1Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}butanoic acid, 5'-DEOXYADENOSINE, COBALAMIN, ... | | 著者 | Wolthers, K.R, Levy, C.W, Scrutton, N.S, Leys, D. | | 登録日 | 2009-11-14 | | 公開日 | 2010-01-26 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase.
J.Biol.Chem., 285, 2010
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3KOZ
 | | Crystal Structure of ornithine 4,5 aminomutase in complex with ornithine (Anaerobic) | | 分子名称: | (E)-N~5~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-ornithine, 5'-DEOXYADENOSINE, COBALAMIN, ... | | 著者 | Wolthers, K.R, Levy, C.W, Scrutton, N.S, Leys, D. | | 登録日 | 2009-11-14 | | 公開日 | 2010-01-26 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase.
J.Biol.Chem., 285, 2010
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3KRZ
 | | Crystal Structure of the Thermostable NADH4-bound old yellow enzyme from Thermoanaerobacter pseudethanolicus E39 | | 分子名称: | 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, NADH:flavin oxidoreductase/NADH oxidase | | 著者 | Adalbjornsson, B.V, Toogood, H.S, Leys, D, Scrutton, N.S. | | 登録日 | 2009-11-20 | | 公開日 | 2009-12-08 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Biocatalysis with thermostable enzymes: structure and properties of a thermophilic 'ene'-reductase related to old yellow enzyme.
Chembiochem, 11, 2010
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4JGI
 | | 1.5 Angstrom crystal structure of a novel cobalamin-binding protein from Desulfitobacterium hafniense DCB-2 | | 分子名称: | CO-METHYLCOBALAMIN, Putative uncharacterized protein | | 著者 | Sjuts, H, Dunstan, M.S, Fisher, K, Leys, D. | | 登録日 | 2013-03-01 | | 公開日 | 2013-08-07 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure of the cobalamin-binding protein of a putative O-demethylase from Desulfitobacterium hafniense DCB-2.
Acta Crystallogr.,Sect.D, 69, 2013
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4LX6
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4LX5
 | | X-ray crystal structure of the M6" riboswitch aptamer bound to pyrimido[4,5-d]pyrimidine-2,4-diamine (PPDA) | | 分子名称: | MAGNESIUM ION, Mutated adenine riboswitch aptamer, pyrimido[4,5-d]pyrimidine-2,4-diamine | | 著者 | Dunstan, M.S, Leys, D. | | 登録日 | 2013-07-29 | | 公開日 | 2014-07-16 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | Modular riboswitch toolsets for synthetic genetic control in diverse bacterial species.
J.Am.Chem.Soc., 136, 2014
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5L53
 | | Menthone neomenthol reductase from Mentha piperita in complex with NADP | | 分子名称: | (-)-menthone:(+)-neomenthol reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Karuppiah, V, Toogood, H.S, Leys, D, Scrutton, N.S. | | 登録日 | 2016-05-27 | | 公開日 | 2016-08-31 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases.
Angew.Chem.Int.Ed.Engl., 55, 2016
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