4J36

Cocrystal Structure of kynurenine 3-monooxygenase in complex with UPF 648 inhibitor(KMO-394UPF)

Summary for 4J36

Entry DOI	10.2210/pdb4j36/pdb
Related	4J2W 4J31 4J33 4J34
Descriptor	Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, (1S,2S)-2-(3,4-dichlorobenzoyl)cyclopropanecarboxylic acid, ... (4 entities in total)
Functional Keywords	monooxygenase kynurenine upf 648, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Saccharomyces cerevisiae (Baker's yeast)
Cellular location	Mitochondrion outer membrane: P38169
Total number of polymer chains	2
Total formula weight	95923.71
Authors	Amaral, M.,Levy, C.,Heyes, D.J.,Lafite, P.,Outeiro, T.F.,Giorgini, F.,Leys, D.,Scrutton, N.S. (deposition date: 2013-02-05, release date: 2013-04-10, Last modification date: 2024-02-28)
Primary citation	Amaral, M.,Levy, C.,Heyes, D.J.,Lafite, P.,Outeiro, T.F.,Giorgini, F.,Leys, D.,Scrutton, N.S. Structural basis of kynurenine 3-monooxygenase inhibition. Nature, 496:382-385, 2013 Cited by PubMed: 23575632 DOI: 10.1038/nature12039 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.13 Å)

Structure validation